sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 1.000 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.675 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.673 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.671 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.665 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.663 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.660 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.655 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.655 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.655 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.654 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.649 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.647 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.645 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.642 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.642 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.641 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.640 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.640 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.640 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.634 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.632 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.632 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.630 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.628 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.625 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.625 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.624 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.624 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.623 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.621 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.616 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.614 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.613 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.613 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.609 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.609 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.608 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.608 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.608 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.607 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.606 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.605 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.603 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.602 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.600 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.599 | |
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.597 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.591 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.585 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.582 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.574 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.564 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.556 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.551 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.547 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.542 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.540 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.529 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.516 | |
| 3ny8 | JRZ | Beta-2 adrenergic receptor | / | 0.502 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.500 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.492 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.489 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.484 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.483 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.483 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.481 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.481 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.480 | |
| 3gsi | THG | Dimethylglycine oxidase | 1.5.3.10 | 0.480 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.480 | |
| 4li8 | 1XQ | Tankyrase-1 | 2.4.2.30 | 0.480 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.478 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.478 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.476 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.474 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.474 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.474 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.474 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.473 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.472 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.471 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 2hzq | STR | Apolipoprotein D | / | 0.471 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.470 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.470 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.469 | |
| 4bvn | P32 | Beta-1 adrenergic receptor | / | 0.469 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.469 | |
| 4li7 | 1XP | Tankyrase-1 | 2.4.2.30 | 0.469 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.468 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.468 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.467 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.467 | |
| 5jqh | CAU | Beta-2 adrenergic receptor | / | 0.467 | |
| 1tfz | 869 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.466 | |
| 3pbl | ETQ | D(3) dopamine receptor | / | 0.466 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.465 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.464 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.463 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.463 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.463 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.463 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.463 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.463 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.463 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.462 | |
| 4hyf | 1AK | Tankyrase-2 | 2.4.2.30 | 0.462 | |
| 4msk | 2C8 | Tankyrase-1 | 2.4.2.30 | 0.462 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.461 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.461 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.461 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.460 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.460 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.460 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.460 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.460 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.460 | |
| 1uk0 | FRM | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.459 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.459 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.459 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.459 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.459 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.458 | |
| 4gvs | F4M | Methenyltetrahydromethanopterin cyclohydrolase | 3.5.4.27 | 0.458 | |
| 4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.458 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.457 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.457 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.457 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.456 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.456 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.456 | |
| 3t31 | DCQ | Sulfide-quinone reductase | / | 0.456 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.456 | |
| 4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.456 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.456 | |
| 1pj7 | FFO | Dimethylglycine oxidase | 1.5.3.10 | 0.455 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.455 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.455 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.454 | |
| 4kn2 | LYA | Folate receptor beta | / | 0.454 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.453 | |
| 3vo2 | FAD | Ferredoxin--NADP reductase | / | 0.453 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.452 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.452 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.452 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.452 | |
| 5a8e | XTK | Beta-1 adrenergic receptor | / | 0.452 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.451 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.451 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.451 | |
| 2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.451 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.451 | |
| 4phl | PIL | Phosphodiesterase | / | 0.451 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.450 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.450 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 4hlm | 16S | Tankyrase-2 | 2.4.2.30 | 0.450 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.450 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 3nhp | HGZ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.449 | |
| 3sfh | 1DI | Histone deacetylase 8 | 3.5.1.98 | 0.449 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.449 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.449 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.449 | |
| 4e2y | JHZ | Methyltransferase | / | 0.449 | |
| 4h7c | 10H | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.449 | |
| 4kmz | FOL | Folate receptor beta | / | 0.449 | |
| 1m9h | NAD | 2,5-diketo-D-gluconic acid reductase A | 1.1.1.346 | 0.448 | |
| 1s2c | FLF | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 4gtr | 7TR | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 4hcy | 0YN | Transketolase | / | 0.448 | |
| 1hqt | NAP | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.447 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.447 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.447 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.447 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.447 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.447 | |
| 4j7h | TRH | PCZA361.3 | / | 0.447 | |
| 4n1f | CZH | Obelin | / | 0.447 | |
| 4nqg | CZH | Mitrocomin | / | 0.447 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.446 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.446 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.446 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.446 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 4jt9 | 1NS | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.446 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.446 | |
| 2ycy | P32 | Beta-1 adrenergic receptor | / | 0.446 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.446 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.446 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.445 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.445 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2jf6 | S55 | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.445 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.445 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.445 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.444 | |
| 2zit | NAD | Exotoxin A | 2.4.2.36 | 0.444 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.444 | |
| 3x04 | GNP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.444 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.444 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.443 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.443 | |
| 3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 3x02 | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.443 | |
| 4jq1 | NPS | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.443 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 1t47 | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.442 | |
| 2tpl | HPP | Tyrosine phenol-lyase | 4.1.99.2 | 0.442 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.442 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.442 | |
| 4x3u | SVR | Chromobox protein homolog 7 | / | 0.442 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.441 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.441 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.441 | |
| 4gbr | CAU | Beta-2 adrenergic receptor | / | 0.441 | |
| 1g60 | SAM | Modification methylase MboII | 2.1.1.72 | 0.440 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.440 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.440 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.440 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.440 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3lz6 | A0D | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.440 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.440 |