sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 1.000 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.750 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.613 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.613 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.553 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.552 | |
| 1std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.549 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.523 | |
| 4iae | 1DX | Alr2278 protein | / | 0.518 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.507 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.505 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.504 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.502 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.499 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.497 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.495 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.493 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.493 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.492 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.491 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.491 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.491 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.488 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.487 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.486 | |
| 1fml | RTL | Retinol dehydratase | / | 0.485 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.485 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.485 | |
| 4boe | CLR | Japanin | / | 0.485 | |
| 4phl | PIL | Phosphodiesterase | / | 0.483 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.481 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.481 | |
| 4iah | 1DX | Alr2278 protein | / | 0.481 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.480 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.480 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.479 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.479 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.478 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.478 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.478 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.477 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.477 | |
| 2h94 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.476 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.476 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.475 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.475 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.474 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.474 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.473 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.472 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.472 | |
| 2rd2 | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.472 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.472 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.471 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.471 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.471 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.471 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.471 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 2pnu | ENM | Androgen receptor | / | 0.470 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.469 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 4kln | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.469 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.468 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.468 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.467 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.467 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.466 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.466 | |
| 1akb | PPD | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.465 | |
| 1c7o | PPG | Hemolysin | / | 0.465 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.465 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.465 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.464 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.464 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.464 | |
| 5bn3 | ADP | V-type ATP synthase alpha chain | / | 0.464 | |
| 5bn3 | ADP | NEQ263 | / | 0.464 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.463 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.463 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.463 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.463 | |
| 4n4t | 2GV | Tankyrase-1 | 2.4.2.30 | 0.463 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.463 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.462 | |
| 3dl9 | V2H | Vitamin D 25-hydroxylase | / | 0.462 | |
| 3rgz | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.462 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.462 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.461 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.461 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.460 | |
| 3p9t | TCL | Repressor | / | 0.460 | |
| 4dyp | 0MS | Nucleoprotein | / | 0.460 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.460 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.459 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.459 | |
| 2p1t | 3TN | Retinoic acid receptor RXR-alpha | / | 0.459 | |
| 4jxx | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.459 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.459 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 1uhh | CZP | Aequorin-2 | / | 0.458 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.458 | |
| 2re8 | GSU | Glutamine--tRNA ligase | 6.1.1.18 | 0.458 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.458 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.458 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.458 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.457 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.457 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.457 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.457 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.457 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.457 | |
| 4n1g | CEI | Obelin | / | 0.457 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.457 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.456 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.456 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.456 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.456 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.456 | |
| 3qj0 | QI3 | Botulinum neurotoxin type A | 3.4.24.69 | 0.456 | |
| 3rc7 | TLO | Sugar 3-ketoreductase | / | 0.456 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.455 | |
| 1toj | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.455 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.455 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.455 | |
| 4jxz | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.455 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.454 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.454 | |
| 4fa3 | 0SL | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.454 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.453 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.453 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.453 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.453 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.452 | |
| 3akm | 11D | Fatty acid-binding protein, intestinal | / | 0.452 | |
| 3c1o | NAP | Eugenol synthase | / | 0.452 | |
| 3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.452 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.452 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.452 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 4j7g | TRH | PCZA361.3 | / | 0.452 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.452 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.452 | |
| 4xwt | U5P | Ribonuclease J | / | 0.452 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.451 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.450 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.450 | |
| 2fhj | H4Z | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.450 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3r6i | JMS | Aldo-keto reductase family 1 member C3 | / | 0.450 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.450 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.450 | |
| 1qv0 | CZH | Obelin | / | 0.449 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.449 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.449 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.449 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.449 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.449 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.449 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.448 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.448 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.448 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.448 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.448 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.448 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.447 | |
| 1xuz | MMN | Capsule biosynthesis protein | / | 0.447 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.447 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.447 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.447 | |
| 3f90 | FMN | Flavodoxin | / | 0.447 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.447 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.447 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.446 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.446 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 0.446 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 2bxo | OPB | Serum albumin | / | 0.446 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.446 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2uuo | LK3 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.446 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.446 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1mtc | GPR | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.445 | |
| 2ejz | SAH | Diphthine synthase | / | 0.445 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.445 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.445 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.445 | |
| 3u9y | 09L | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 1euy | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.444 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.444 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3w5h | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.444 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.444 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.444 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE26 | / | 0.444 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE27 | / | 0.444 | |
| 4ami | G90 | Beta-1 adrenergic receptor | / | 0.444 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.443 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.443 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.443 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.443 | |
| 2y05 | RAL | Prostaglandin reductase 1 | / | 0.443 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.443 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.443 | |
| 3n9j | EAA | Glutathione S-transferase P | 2.5.1.18 | 0.443 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.443 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4tkg | 09L | Tankyrase-2 | 2.4.2.30 | 0.443 | |
| 1gtr | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.442 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.442 | |
| 2rdn | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.442 | |
| 3b8h | NAD | Exotoxin A | 2.4.2.36 | 0.442 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.442 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.441 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.441 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.441 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.441 | |
| 1s36 | CEI | Obelin | / | 0.441 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 3abx | RCB | Glucanase | / | 0.441 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.441 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.441 | |
| 1el4 | CTZ | Obelin | / | 0.440 | |
| 1i05 | LTL | Major urinary protein 6 | / | 0.440 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.440 | |
| 2mm3 | CHO | Gastrotropin | / | 0.440 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.440 | |
| 3up3 | XCA | aceDAF-12 | / | 0.440 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.440 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.440 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.440 | |
| 4eqr | COA | Coenzyme A disulfide reductase | / | 0.440 | |
| 4fal | 0T0 | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.440 |