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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3sjuNDPKeto reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3sjuNDPKeto reductase/1.000
1w4zNAPPutative ketoacyl reductase1.3.10.552
3qrwNDPPutative ketoacyl reductase1.3.10.541
4dc1NDPPutative ketoacyl reductase1.3.10.536
1x7gNAPPutative ketoacyl reductase1.3.10.530
1x7hNDPPutative ketoacyl reductase1.3.10.524
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.509
5jlaNADPutative short-chain dehydrogenase/reductase/0.495
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.494
4j7xNAPSepiapterin reductase1.1.1.1530.491
1ae1NAPTropinone reductase 1/0.488
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.480
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.478
4j7uNAPSepiapterin reductase1.1.1.1530.478
3p19NDPPutative blue fluorescent protein/0.475
1xg5NAPDehydrogenase/reductase SDR family member 11/0.473
4hwkNAPSepiapterin reductase1.1.1.1530.473
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.471
1ipeNDPTropinone reductase 21.1.1.2360.467
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.464
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.464
4qecNAPElxO/0.464
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.463
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.463
4esoNAPPutative oxidoreductase/0.459
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.452
3f1kNAPUncharacterized oxidoreductase YciK10.452
3toxNAPPutative oxidoreductase/0.452
4bmvNAPShort-chain dehydrogenase/0.451
1snyNAPLD36273p/0.450
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.449
2bd0NAPSepiapterin reductase/0.448
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.447
1wntNAPL-xylulose reductase1.1.1.100.446
3l77NJPShort-chain alcohol dehydrogenase/0.446
2wsbNADGalactitol dehydrogenase/0.444
3ai2NDPNADPH-sorbose reductase/0.443
1pr9NAPL-xylulose reductase1.1.1.100.440
1xkqNDPUncharacterized protein/0.440
3gy0NAPNAD(P)-dependent oxidoreductase/0.440
3lqfNADGalactitol dehydrogenase/0.440
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.440