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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3s41S41Glucokinase2.7.1.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3s41S41Glucokinase2.7.1.21.000
4dhyS41Glucokinase2.7.1.20.929
3vf60H6Glucokinase2.7.1.20.591
4ixc1JDGlucokinase2.7.1.20.577
4iwv1J9Glucokinase2.7.1.20.575
1xddAAYIntegrin alpha-L/0.522
4dch4DCGlucokinase2.7.1.20.508
5ab7MLCNonspecific lipid-transfer protein, putative/0.506
3nxyD2HDihydrofolate reductase1.5.1.30.501
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.500
4r20AERCytochrome P450 family 17 polypeptide 2/0.494
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.494
3t8xT8XT-cell surface glycoprotein CD1b/0.491
4isg1FYGlucokinase2.7.1.20.489
1h36R88Squalene--hopene cyclase4.2.1.1290.487
3a0iAJIGlucokinase2.7.1.20.487
4uymVOR14-alpha sterol demethylase Cyp51B/0.487
3bsyACOUDP-N-acetylbacillosamine N-acetyltransferase2.3.1.2030.486
3p99LNPLanosterol 14-alpha-demethylase/0.485
4iarERM5-hydroxytryptamine receptor 1B/0.485
5ab6CAANonspecific lipid-transfer protein, putative/0.485
1ndzFR5Adenosine deaminase3.5.4.40.483
2b01TUDPhospholipase A2, major isoenzyme3.1.1.40.482
3l0lHC3Nuclear receptor ROR-gamma/0.482
1ry0PG2Aldo-keto reductase family 1 member C3/0.481
2z7gEH9Adenosine deaminase3.5.4.40.481
3l6jZ90Alr2278 protein/0.480
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.479
1pz1NAPGeneral stress protein 69/0.478
1ygkRRCPyridoxal kinase2.7.1.350.478
5hs1VORLanosterol 14-alpha demethylase/0.478
1o6qR17Squalene--hopene cyclase4.2.1.1290.477
3ds6A17Mitogen-activated protein kinase 14/0.476
3zoiM2WIsopenicillin N synthase1.21.3.10.476
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.476
3gncQQQGlutaryl-CoA dehydrogenase/0.475
1fx9MJIPhospholipase A2, major isoenzyme3.1.1.40.474
3g70A5TRenin3.4.23.150.472
5g53NECAdenosine receptor A2a/0.472
4ddrMMVDihydrofolate reductase1.5.1.30.471
4ktl1CQCytochrome P450/0.471
1yhjR6CPyridoxal kinase2.7.1.350.470
3c3xNAPEugenol synthase 11.1.1.3180.469
3oadLPORenin3.4.23.150.469
3p3zP3ZPutative cytochrome P450/0.468
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.467
4iah1DXAlr2278 protein/0.467
4l8u9AZSerum albumin/0.467
4g3jVNTLanosterol 14-alpha-demethylase/0.466
1q20PLOSulfotransferase family cytosolic 2B member 12.8.2.20.464
1ygjRMCPyridoxal kinase2.7.1.350.464
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.464
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.464
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.464
4iae1DXAlr2278 protein/0.464
4n4t2GVTankyrase-12.4.2.300.464
1fd0254Retinoic acid receptor gamma/0.463
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.463
1xuoLA1Integrin alpha-L/0.463
2d29FADAcyl-CoA dehydrogenase/0.463
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.463
3gw9VNILanosterol 14-alpha-demethylase/0.463
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.463
4lb2DM5Serum albumin/0.463
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.462
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.462
3wixLC3Induced myeloid leukemia cell differentiation protein Mcl-1/0.462
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.462
4zm6ACON-acetyl-beta-D glucosaminidase/0.462
1cqp803Integrin alpha-L/0.461
1pqc444Oxysterols receptor LXR-beta/0.461
1umlFR4Adenosine deaminase3.5.4.40.460
2z3uCRRCytochrome P450/0.460
3iktNADRedox-sensing transcriptional repressor Rex/0.460
1o5rFR9Adenosine deaminase3.5.4.40.459
1pkfEPDEpothilone C/D epoxidase1.140.459
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.459
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.459
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.459
3o73O73Ribosyldihydronicotinamide dehydrogenase [quinone]/0.459
1h35R01Squalene--hopene cyclase4.2.1.1290.458
3a1l2CCCytochrome P450/0.458
3fnfJPMEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.458
4jqh1MFAlr2278 protein/0.458
4nieNBHNuclear receptor ROR-gamma/0.458
3tl1JROPutative polyketide cyclase/0.457
3up0D7SaceDAF-12/0.457
3wv9FEGHmd co-occurring protein HcgE/0.457
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.457
2p15EZTEstrogen receptor/0.456
3gkjHC3Niemann-Pick C1 protein/0.456
3up3XCAaceDAF-12/0.456
4ips1G4Mycocyclosin synthase1.14.21.90.456
4b6l9ZPSerine/threonine-protein kinase PLK32.7.11.210.455
4iaq2GM5-hydroxytryptamine receptor 1B/0.455
3oagLPQRenin3.4.23.150.454
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
1p33MTXPteridine reductase 11.5.1.330.453
1zq5E04Aldo-keto reductase family 1 member C3/0.453
2ab8MTPAdenosine kinase2.7.1.200.453
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.453
2pl0STITyrosine-protein kinase Lck2.7.10.20.453
3p9tTCLRepressor/0.453
4mv1ADPBiotin carboxylase6.3.4.140.453
1c7oPPGHemolysin/0.452
1exa394Retinoic acid receptor gamma/0.452
1jomFFODihydrofolate reductase1.5.1.30.452
1o6rR19Squalene--hopene cyclase4.2.1.1290.452
1q5dEPBEpothilone C/D epoxidase1.140.452
1synF89Thymidylate synthase/0.452
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.452
2nn7M29Carbonic anhydrase 14.2.1.10.452
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.452
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.452
3bhrTHGThymidylate synthase/0.452
4ap1NAPSteroid monooxygenase/0.452
4jlj1NMDeoxycytidine kinase2.7.1.740.452
1puaCOAHAT A1/0.451
1wuuANPGalactokinase2.7.1.60.451
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.451
3vo2FADFerredoxin--NADP reductase/0.451
3vtbTKAVitamin D3 receptor/0.451
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.451
4bfpSWYTankyrase-22.4.2.300.451
1disBDMDihydrofolate reductase1.5.1.30.450
1e7qNAPGDP-L-fucose synthase/0.450
2w4qCBWProstaglandin reductase 21.3.1.480.450
3n0hTOPDihydrofolate reductase1.5.1.30.450
5kf2ACOPredicted acetyltransferase/0.450
1fcx184Retinoic acid receptor gamma/0.449
1mczRMNBenzoylformate decarboxylase4.1.1.70.449
1u1d181Uridine phosphorylase2.4.2.30.449
1zg32HIIsoflavone 4'-O-methyltransferase/0.449
2p1t3TNRetinoic acid receptor RXR-alpha/0.449
2po7CHDFerrochelatase, mitochondrial4.99.1.10.449
3w0uHPWLactoylglutathione lyase4.4.1.50.449
3zkyWT4Isopenicillin N synthase1.21.3.10.449
4g1nNZTPyruvate kinase PKM2.7.1.400.449
4g7gVFVLanosterol 14-alpha-demethylase/0.449
4h9506UDihydrofolate reductase1.5.1.30.449
3emlZMAAdenosine receptor A2a/0.449
1jf2CZHObelin/0.448
1yw8A75Methionine aminopeptidase 2/0.448
2bf7HBIPteridine reductase 11.5.1.330.448
2ea2F77Methionine aminopeptidase 2/0.448
2gfsPQBMitogen-activated protein kinase 14/0.448
2obxINI6,7-dimethyl-8-ribityllumazine synthase 22.5.1.780.448
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.448
3tdaPN0Cytochrome P450 2D6/0.448
3u8dU8DPhospholipase A2, membrane associated/0.448
4ea2RWZDehydrosqualene synthase/0.448
4ixd1HVIntegrin alpha-L/0.448
4q71FADBifunctional protein PutA/0.448
1g6oADPCag alpha/0.447
1m13HYFNuclear receptor subfamily 1 group I member 2/0.447
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
1wxyFRKAdenosine deaminase3.5.4.40.447
1x8vESLLanosterol 14-alpha demethylase1.14.13.700.447
2a9z26AAdenosine kinase2.7.1.200.447
2f3815MAldo-keto reductase family 1 member C3/0.447
2g263LGRenin3.4.23.150.447
2iyaZIOOleandomycin glycosyltransferase/0.447
2pnuENMAndrogen receptor/0.447
3bxxQUEDihydroflavonol 4-reductase1.1.1.2190.447
3e5aVX6Aurora kinase A2.7.11.10.447
4bfyZVYPantothenate kinase2.7.1.330.447
1ry8RUTAldo-keto reductase family 1 member C3/0.446
1yc2NADNAD-dependent protein deacylase 2/0.446
3abaFLICytochrome P450/0.446
3g5hYTTMycocyclosin synthase1.14.21.90.446
4j6bPLOCytochrome P450 monooxygenase/0.446
4nc3ERM5-hydroxytryptamine receptor 2B/0.446
4nzhFADL-ornithine N(5)-monooxygenase/0.446
5k2cZMAAdenosine receptor A2a/0.446
1nytNAPShikimate dehydrogenase (NADP(+))/0.445
2jblSMAReaction center protein L chain/0.445
2lbdREARetinoic acid receptor gamma/0.445
3fkoFKOMitogen-activated protein kinase 14/0.445
4a81DXCMajor pollen allergen Bet v 1-A/0.445
4krs1SXTankyrase-12.4.2.300.445
5bp9SAHPutative methyltransferase protein/0.445
1oj4CDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.444
1pq944BOxysterols receptor LXR-beta/0.444
1qtqQSIGlutamine--tRNA ligase6.1.1.180.444
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.444
2jedLG8Protein kinase C theta type2.7.11.130.444
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.444
3fl4FL4Mitogen-activated protein kinase 14/0.444
3vt9YI4Vitamin D3 receptor/0.444
4b4w9L9Bifunctional protein FolD/0.444
4bb3KKAIsopenicillin N synthase1.21.3.10.444
4jbtASDCytochrome P450 monooxygenase/0.444
4n4v2GYTankyrase-12.4.2.300.444
4qa0SHHHistone deacetylase 83.5.1.980.444
1fxfMJIPhospholipase A2, major isoenzyme3.1.1.40.443
1hfqMOTDihydrofolate reductase1.5.1.30.443
1zprCB3Thymidylate synthase/0.443
2bfaCB3Pteridine reductase 11.5.1.330.443
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.443
2ie0ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2jb4A14Isopenicillin N synthase1.21.3.10.443
2jdcCAOProbable acetyltransferase/0.443
3qm4PN0Cytochrome P450 2D6/0.443
4qii2NE1,4-dihydroxy-2-naphthoyl-CoA synthase/0.443
4u9vACON-alpha-acetyltransferase 402.3.10.443
5dozNDPJamJ/0.443
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1s36CEIObelin/0.442
2fgjATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.442
2fs4PZ1Renin3.4.23.150.442
2lfoGCHFatty acid-binding protein, liver/0.442
2uxhQUEHTH-type transcriptional regulator TtgR/0.442
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.442
3kytHC2Nuclear receptor ROR-gamma/0.442
3v94WYQPhosphodiesterase/0.442
4at0FADPossible succinate dehydrogenase/0.442
4bftZVTPantothenate kinase2.7.1.330.442
4gs4ACOAlpha-tubulin N-acetyltransferase 1/0.442
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.442
5iu4ZMAAdenosine receptor A2a/0.442
1crbRTLRetinol-binding protein 1/0.441
1ezfIN0Squalene synthase2.5.1.210.441
1fwmCB3Thymidylate synthase/0.441
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.441
2wd8VGFPteridine reductase/0.441
2y60M8FIsopenicillin N synthase1.21.3.10.441
3eigMTXDihydrofolate reductase1.5.1.30.441
3hub469Mitogen-activated protein kinase 14/0.441
4fhf0TTSpore photoproduct lyase/0.441
4h7c10HAldo-keto reductase family 1 member C3/0.441
4ise1FWGlucokinase2.7.1.20.441
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.441
4o7uTHFThymidylate synthase/0.441
5c93ACPTwo-component system histidine protein kinase/0.441
5uviZMAAdenosine receptor A2a/0.441
1qiqACCIsopenicillin N synthase1.21.3.10.440
1tysDHFThymidylate synthase/0.440
2hxzH7JCathepsin S3.4.22.270.440
2yac937Serine/threonine-protein kinase PLK12.7.11.210.440
3ey4352Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3lfcZ86Mitogen-activated protein kinase 14/0.440
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4go2TAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.440
4iq71G9Mycocyclosin synthase1.14.21.90.440
4zhiADPKinesin-like protein KIF11/0.440