sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3ryp | CMP | cAMP-activated global transcriptional regulator CRP |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3ryp | CMP | cAMP-activated global transcriptional regulator CRP | / | 1.000 | |
| 1i5z | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.682 | |
| 4i0a | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.642 | |
| 4hzf | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.628 | |
| 4i09 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.625 | |
| 3kcc | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.610 | |
| 1i6x | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.606 | |
| 4i0b | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.597 | |
| 1cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.588 | |
| 4i01 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.579 | |
| 2gzw | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.576 | |
| 1g6n | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.570 | |
| 2oz6 | CMP | Cyclic AMP receptor-like protein | / | 0.563 | |
| 3ryr | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.559 | |
| 1ruo | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.549 | |
| 4ft8 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.541 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.535 | |
| 4r8h | SP1 | cAMP-activated global transcriptional regulator CRP | / | 0.527 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.521 | |
| 3rou | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.515 | |
| 1zrd | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.511 | |
| 4n9i | PCG | Catabolite expression activator | / | 0.511 | |
| 3otf | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.509 | |
| 1zrc | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.500 | |
| 3rpq | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.500 | |
| 1q43 | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | / | 0.499 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.495 | |
| 3qop | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.493 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.493 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.490 | |
| 3mzh | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.490 | |
| 3rdi | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.490 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.489 | |
| 3u0z | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | / | 0.489 | |
| 1hw5 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.486 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.486 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.486 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.485 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.482 | |
| 4hjo | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.481 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.480 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.480 | |
| 2wec | PP5 | Penicillopepsin-1 | 3.4.23.20 | 0.479 | |
| 3nbv | ANP | Ketohexokinase | / | 0.478 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.478 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.477 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.477 | |
| 1msm | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.475 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.474 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.474 | |
| 1q3e | PCG | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | / | 0.473 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.473 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.473 | |
| 5dp2 | NAP | CurF | / | 0.473 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.472 | |
| 3pwm | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.472 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.472 | |
| 3kgc | LY7 | Glutamate receptor 2 | / | 0.471 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.470 | |
| 5a3b | APR | SIR2 family protein | / | 0.470 | |
| 1vp6 | CMP | Cyclic nucleotide-gated potassium channel mll3241 | / | 0.469 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.469 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.469 | |
| 1bv9 | XV6 | Gag-Pol polyprotein | 3.4.23.16 | 0.468 | |
| 2bpw | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.468 | |
| 3dme | FAD | Putative conserved exported protein | / | 0.468 | |
| 2ign | FAD | Pyranose 2-oxidase | / | 0.467 | |
| 2ooy | ATP | 5'-AMP-activated protein kinase subunit gamma | / | 0.467 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.467 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.467 | |
| 4c4o | NAD | SADH | / | 0.467 | |
| 5k5z | ANP | Uncharacterized protein | / | 0.467 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.466 | |
| 2i3g | NAP | N-acetyl-gamma-glutamyl-phosphate reductase | 1.2.1.38 | 0.466 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.466 | |
| 3uqd | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.466 | |
| 4abz | T1C | Tetracycline repressor protein class D | / | 0.466 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.465 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.465 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.465 | |
| 3cl1 | PCG | Cyclic nucleotide-gated potassium channel mll3241 | / | 0.465 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.465 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.465 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.464 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.464 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.464 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.464 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.464 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.463 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.463 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.463 | |
| 2z54 | AB1 | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 3ekp | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.462 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.461 | |
| 1sgu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 2e9v | 85A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 3mdd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.461 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.461 | |
| 3wle | NAD | (R)-specific carbonyl reductase | / | 0.461 | |
| 1p0f | NAP | NADP-dependent alcohol dehydrogenase | 1.1.1.2 | 0.460 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.460 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.460 | |
| 3zuy | TCH | Transporter | / | 0.460 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.460 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.460 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.459 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.459 | |
| 2hck | QUE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.459 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.459 | |
| 3cyw | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
| 3d8b | ADP | Fidgetin-like protein 1 | 3.6.4 | 0.459 | |
| 3lzs | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.459 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.459 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.459 | |
| 1bwa | XV6 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.458 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.458 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.458 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.458 | |
| 3n4m | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.458 | |
| 3toh | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.458 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 4o8a | FAD | Bifunctional protein PutA | 1.2.1.88 | 0.458 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.458 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.457 | |
| 1gp2 | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.457 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.457 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.457 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.457 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.457 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
| 3e8n | VRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.457 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.457 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.457 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.457 | |
| 4hbn | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.457 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.457 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.457 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.456 | |
| 1gqt | ACP | Ribokinase | / | 0.456 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.456 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.456 | |
| 2gtn | LIE | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 3etg | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.456 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.456 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.456 | |
| 4b5p | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.456 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.456 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.456 | |
| 4jld | ADP | Adenylate kinase | / | 0.456 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.456 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.456 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.455 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.455 | |
| 1vik | BAY | Gag-Pol polyprotein | / | 0.455 | |
| 1yon | A2R | 2-dehydropantoate 2-reductase | 1.1.1.169 | 0.455 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.455 | |
| 2w6n | OA2 | Biotin carboxylase | 6.3.4.14 | 0.455 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.455 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.455 | |
| 1gv0 | NAD | Malate dehydrogenase | / | 0.454 | |
| 1llu | NAD | Alcohol dehydrogenase | / | 0.454 | |
| 1npv | L27 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.454 | |
| 2pe1 | 517 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.454 | |
| 3r4b | 74T | Gag-Pol polyprotein | / | 0.454 | |
| 1ek5 | NAD | UDP-glucose 4-epimerase | / | 0.453 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 1kev | NDP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.453 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.453 | |
| 1yre | COA | Uncharacterized protein | / | 0.453 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.453 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.453 | |
| 2cvz | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.453 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.453 | |
| 2x3n | FAD | Probable FAD-dependent monooxygenase | / | 0.453 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 3tog | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.453 | |
| 4nxv | GDP | Mitochondrial dynamics protein MID51 | / | 0.453 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.453 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.452 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.452 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.452 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.452 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.452 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.452 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.452 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.452 | |
| 3hwr | NDP | 2-dehydropantoate 2-reductase | / | 0.452 | |
| 3kyb | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.452 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.451 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.451 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.451 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.451 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.451 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.451 | |
| 3ik6 | HCZ | Glutamate receptor 2 | / | 0.451 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.451 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.451 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.451 | |
| 4ki8 | ADP | 60 kDa chaperonin | / | 0.451 | |
| 4njs | G08 | Protease | / | 0.451 | |
| 5cdt | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.451 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.451 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.450 | |
| 1hsg | MK1 | Gag-Pol polyprotein | / | 0.450 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.450 | |
| 1om1 | IQA | Casein kinase II subunit alpha | 2.7.11.1 | 0.450 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.450 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.450 | |
| 2zgz | GNP | Plasmid segregation protein ParM | / | 0.450 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.450 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.450 | |
| 4n3c | UD1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.450 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.450 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.450 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.450 | |
| 1f0x | FAD | D-lactate dehydrogenase | 1.1.1.28 | 0.449 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.449 | |
| 1h2b | NAJ | NAD-dependent alcohol dehydrogenase | / | 0.449 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.449 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.449 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.449 | |
| 3ksd | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1 | / | 0.449 | |
| 3orz | BI4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.449 | |
| 3oxv | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.449 | |
| 3w8q | AGS | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.449 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.449 | |
| 4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.449 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.449 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.448 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.448 | |
| 1jqi | CAA | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.448 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2b8l | 5HA | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.448 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.448 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.448 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.448 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.448 | |
| 2xpv | MIY | Tetracycline repressor protein class D | / | 0.448 | |
| 3i59 | N6S | CRP-like cAMP-activated global transcriptional regulator | / | 0.448 | |
| 3oct | 1N1 | Tyrosine-protein kinase BTK | 2.7.10.2 | 0.448 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.448 | |
| 4kb9 | G79 | Protease | / | 0.448 | |
| 4kx6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.448 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.448 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.448 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.447 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.447 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.447 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.447 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.447 | |
| 3oq6 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 3uyt | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.447 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.447 | |
| 4f9m | FCM | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.446 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.446 | |
| 1sny | NAP | LD36273p | / | 0.446 | |
| 1xl5 | 190 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1ykf | NAP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.446 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.446 | |
| 3slz | 3TL | Putative gag-pro-pol polyprotein | / | 0.446 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.446 | |
| 5a3c | NAD | SIR2 family protein | / | 0.446 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.445 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.445 | |
| 1iy8 | NAD | Levodione reductase | / | 0.445 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 1rw8 | 580 | TGF-beta receptor type-1 | 2.7.11.30 | 0.445 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.445 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.445 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.445 | |
| 2vd5 | BI8 | Myotonin-protein kinase | 2.7.11.1 | 0.445 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.445 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.445 | |
| 3i99 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.445 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.445 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.445 | |
| 4hxy | NDP | Plm1 | / | 0.445 | |
| 4z26 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.445 | |
| 5hsa | FAS | Alcohol oxidase 1 | 1.1.3.13 | 0.445 | |
| 5hws | NAP | 2-dehydropantoate 2-reductase | / | 0.445 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1heu | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 1lld | NAD | L-lactate dehydrogenase 2 | 1.1.1.27 | 0.444 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.444 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.444 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.444 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.444 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.444 | |
| 2o7o | DXT | Tetracycline repressor protein class D | / | 0.444 | |
| 2vwz | 7X6 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.444 | |
| 3rwp | ABQ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 3sm2 | 478 | Putative gag-pro-pol polyprotein | / | 0.444 | |
| 3u11 | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.444 | |
| 3u33 | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.444 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.444 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.444 | |
| 3w32 | W32 | Epidermal growth factor receptor | 2.7.10.1 | 0.444 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 4die | C5P | Cytidylate kinase | / | 0.444 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.444 | |
| 4jub | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.444 | |
| 4njv | RIT | Protease | / | 0.444 | |
| 4px9 | ADP | ATP-dependent RNA helicase DDX3X | 3.6.4.13 | 0.444 | |
| 5kjc | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 1d4h | BEH | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1efp | FAD | Electron transfer flavoprotein subunit alpha | / | 0.443 | |
| 1okk | GCP | Signal recognition particle protein | / | 0.443 | |
| 1okk | GCP | Signal recognition particle receptor FtsY | / | 0.443 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.443 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.443 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.443 | |
| 1zmd | NAI | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.443 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.443 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.443 | |
| 2vj6 | VG5 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.443 | |
| 3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.443 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.443 | |
| 3zm4 | 22T | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.443 | |
| 4a4q | UX9 | Pol protein | / | 0.443 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.443 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.443 | |
| 4prx | ADP | DNA gyrase subunit B | / | 0.443 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.443 | |
| 4w6z | 8ID | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.443 | |
| 4wqm | FAD | Toluene-4-monooxygenase electron transfer component | 1.18.1.3 | 0.443 | |
| 4xqc | NAD | Homospermidine synthase | 2.5.1.44 | 0.443 | |
| 4z38 | FMN | MlnA | / | 0.443 | |
| 1d4j | MSC | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1ec3 | MS3 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 2brh | DFW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2fze | APR | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.442 | |
| 2oxi | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 2p3b | 3TL | V-1 PROTEASE protein | / | 0.442 | |
| 2p3b | 3TL | V-1 protease | / | 0.442 | |
| 2vhv | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.442 | |
| 3gi6 | D78 | Gag-Pol polyprotein | / | 0.442 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.442 | |
| 3h3c | P1E | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.442 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.442 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.442 | |
| 3nu5 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.442 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.442 | |
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.442 | |
| 3uqd | ADP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.442 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.442 | |
| 3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 4kwh | NAP | Reductase homolog | / | 0.442 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.442 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.442 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.441 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.441 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.441 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.441 | |
| 3ad6 | KSC | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.441 | |
| 3d1z | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3o9h | K2E | Gag-Pol polyprotein | / | 0.441 | |
| 3rv6 | VAE | Salicylate synthase | / | 0.441 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.441 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 4d7t | CMP | Uncharacterized protein | / | 0.441 | |
| 4j5j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.441 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1hyh | NAD | L-2-hydroxyisocaproate dehydrogenase | / | 0.440 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 1rbm | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.440 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.440 | |
| 1t7j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.440 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.440 | |
| 1xkd | NAP | Isocitrate dehydrogenase [NADP] | / | 0.440 | |
| 1yqx | NAP | Sinapyl alcohol dehydrogenase | / | 0.440 | |
| 2avv | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2bi4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.440 | |
| 2nnk | ROC | Protease | / | 0.440 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.440 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.440 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 3bvb | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.440 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.440 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.440 | |
| 3t3c | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.440 | |
| 3zc6 | VFC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.440 | |
| 3zpt | M8Y | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.440 | |
| 4d86 | ADP | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.440 | |
| 4e8y | IHA | D-beta-D-heptose 7-phosphate kinase | / | 0.440 |