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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3rs7GNPGTPase HRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3rs7GNPGTPase HRas/1.000
3rs5GNPGTPase HRas/0.727
2rgbGNPGTPase HRas/0.719
4dlzGNPGTPase HRas/0.718
4dlsGNPGTPase HRas/0.717
3oivGNPGTPase HRas/0.709
3lbnGNPGTPase HRas/0.698
3rslGNPGTPase HRas/0.666
2rgcGNPGTPase HRas/0.653
4dlxGNPGTPase HRas/0.653
4dlvGNPGTPase HRas/0.646
5dhaGNPGTP-binding nuclear protein Ran/0.639
4g0nGNPGTPase HRas/0.631
5b2zGNPGTPase HRas/0.631
3rs0GNPGTPase HRas/0.624
4dlwGNPGTPase HRas/0.621
3i3sGNPGTPase HRas/0.620
4k81GTPGTPase HRas/0.613
4nyiGNPGTPase HRas/0.611
4dltGNPGTPase HRas/0.610
3v4fGNPGTPase HRas/0.609
3rabGNPRas-related protein Rab-3A/0.606
4lhwGNPRas-related protein Rab-8A/0.605
1g17GNPRas-related protein SEC4/0.604
2rgeGNPGTPase HRas/0.604
3l8yGNPGTPase HRas/0.603
3oiuGNPGTPase HRas/0.603
5difGNPGTP-binding nuclear protein Ran/0.602
3oiwGNPGTPase HRas/0.591
4mitGTPRho-related protein racC/0.586
3pitGNPRas-related protein M-Ras/0.585
3rs4GNPGTPase HRas/0.582
3a6pGTPGTP-binding nuclear protein Ran/0.576
3kkoGNPRas-related protein M-Ras/0.572
3ea5GDPGTP-binding nuclear protein Ran/0.570
4dsnGCPGTPase KRas/0.569
3ddcGNPGTPase HRas/0.568
2c5lGTPGTPase HRas/0.567
1t91GTPRas-related protein Rab-7a/0.565
5jljGNPGTP-binding nuclear protein Ran/0.564
1zbdGTPRas-related protein Rab-3A/0.562
3kucGDPRas-related protein Rap-1A/0.562
1zd9GDPADP-ribosylation factor-like protein 8A/0.561
4l9wGNPGTPase HRas/0.560
1yzqGNPRas-related protein Rab-6A/0.558
2gilGTPRas-related protein Rab-6A/0.557
1zc3GNPRas-related protein Ral-A/0.555
3tsoGNPRas-related protein Rab-25/0.555
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.553
4nyjGNPGTPase HRas/0.553
4qxaGTPRas-related protein Rab-9A/0.553
3a58GNPGTP-binding protein RHO1/0.549
3x1zGNPRas-related protein Rap-1b/0.545
4rkfGNPRas-related protein Rab-3/0.545
1xtsGTPGTP-binding protein Rheb/0.544
3oesGNPGTPase RhebL1/0.543
3kudGDPGTPase HRas/0.542
1e96GTPRas-related C3 botulinum toxin substrate 1/0.541
4hdoGNPRas-related protein Rap-1b/0.540
3w3zGTPGTP-binding nuclear protein Ran/0.539
1kmqGNPTransforming protein RhoA/0.538
2bkuGTPGTP-binding nuclear protein Ran/0.538
4ol0GTPGTP-binding nuclear protein Ran/0.537
3bbpGTPRas-related protein Rab-6A/0.536
3bc1GNPRas-related protein Rab-27A/0.536
1cxzGSPTransforming protein RhoA/0.535
4kvgGTPRas-related protein Rap-1A/0.535
1ibrGNPGTP-binding nuclear protein Ran/0.534
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.533
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.530
3lawGNPRas-related protein Rab-7a/0.530
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.529
3nbzGTPGTP-binding nuclear protein Ran/0.526
1m7bGTPRho-related GTP-binding protein RhoE/0.525
1xtrGNPGTP-binding protein Rheb/0.525
1zc4GNPRas-related protein Ral-A/0.524
3e5hGNPRas-related protein Rab-28/0.524
1oixGDPRas-related protein Rab-11A/0.521
2zetGTPRas-related protein Rab-27B/0.520
4hdqGNPRas-related protein Rap-1b/0.520
3tnfGNPRas-related protein Rab-8A/0.519
4uj3GNPRas-related protein Rab-11A/0.518
2fe4GDPRas-related protein Rab-6B/0.517
3lbhGNPGTPase HRas/0.516
4cymGCPRas-related protein Rab-32/0.516
3k8yGNPGTPase HRas/0.510
1vg8GNPRas-related protein Rab-7a/0.509
3lbiGNPGTPase HRas/0.506
4lv6GDPGTPase KRas/0.506
1yhnGTPRas-related protein Rab-7a/0.504
2ffqGSPRas-related protein Rab-6B/0.501
4xoiGTPTransforming protein RhoA/0.500
4dsoGSPGTPase KRas/0.499
4dsuGDPGTPase KRas/0.498
2msdGNPMHC class I alpha chain/0.496
4js0GNPCell division control protein 42 homolog/0.496
4tq9GDPGTPase KRas/0.496
2gcpGSPRho-related GTP-binding protein RhoC/0.494
3wygGTPGTP-binding nuclear protein GSP1/CNR1/0.494
1a2bGSPTransforming protein RhoA/0.493
4o25GTPGTP-binding protein Rheb/0.493
1k5dGNPGTP-binding nuclear protein Ran/0.492
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.491
3kkqGDPRas-related protein M-Ras/0.489
4lucGDPGTPase KRas/0.489
3kz1GSPTransforming protein RhoA/0.488
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.487
3qbtGNPRas-related protein Rab-8A/0.487
1uadGNPRas-related protein Ral-A/0.485
4obeGDPGTPase KRas/0.484
1ow3GDPTransforming protein RhoA/0.483
1s1cGNPTransforming protein RhoA/0.483
2ce2GDPGTPase HRas/0.482
4lpkGDPGTPase KRas/0.482
4o2lGTPGTP-binding protein Rheb/0.482
1g16GDPRas-related protein SEC4/0.480
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.480
3mjhGTPRas-related protein Rab-5A/0.480
3wyfGTPGTP-binding nuclear protein/0.480
3th5GNPRas-related C3 botulinum toxin substrate 1/0.478
3cphGDPRas-related protein SEC4/0.474
4ql3GDPGTPase KRas/0.473
4uj5GNPRas-related protein Rab-11A/0.472
1x1rGDPRas-related protein M-Ras/0.471
3tgpGNPGTPase HRas/0.470
4l9sGDPGTPase HRas/0.470
5hpyGDPTransforming protein RhoA/0.470
4epxGDPGTPase KRas/0.468
1lfdGNPGTPase HRas/0.467
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.467
1z2aGDPRas-related protein Rab-23/0.466
4dxaGSPRas-related protein Rap-1b/0.466
1qiqACCIsopenicillin N synthase1.21.3.10.463
1n6lGTPRas-related protein Rab-5A/0.461
1yu9GNPRas-related protein Rab-4A/0.459
2clsGTPRho-related GTP-binding protein Rho6/0.459
3tklGTPRas-related protein Rab-1A/0.458
5c46GSPRas-related protein Rab-11A/0.458
2vbdV10Isopenicillin N synthase1.21.3.10.457
3eg5GNPCell division control protein 42 homolog/0.457
1qjfACSIsopenicillin N synthase1.21.3.10.456
2jb4A14Isopenicillin N synthase1.21.3.10.456
4q03GDPGTPase KRas/0.455
2c29NAPDihydroflavonol 4-reductase/0.454
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.454
4wa7GDPGTPase KRas/0.454
4xvrGNPGTPase HRas/0.454
1d5cGDPGTPase (Rab6)/0.452
2cl6CAGGTPase HRas/0.452
4q02GDPGTPase KRas/0.452
1z0aGDPRas-related protein Rab-2A/0.450
4ldjGDPGTPase KRas/0.450
4xvqGNPGTPase HRas/0.449
2rggGNPGTPase HRas/0.448
4l8gGDPGTPase KRas/0.448
1tu3GNPRas-related protein Rab-5A/0.446
4lrwGDPGTPase KRas/0.446
4if5ACOAlpha-tubulin N-acetyltransferase 1/0.445
2y8lADP5'-AMP-activated protein kinase subunit gamma-1/0.444
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.440
3f63GTXGlutathione transferase GST1-4/0.440
4epwGDPGTPase KRas/0.440
4o2rGDPGTP-binding protein Rheb/0.440