sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 1.000 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.732 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.637 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.623 | |
| 1u2o | NEC | Endoplasmin | / | 0.596 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.596 | |
| 3rlr | 3RR | Heat shock protein HSP 90-alpha | / | 0.579 | |
| 1ysz | NEC | Endoplasmin | / | 0.578 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.577 | |
| 1qy8 | RDI | Endoplasmin | / | 0.575 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.570 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.568 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.563 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.560 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.554 | |
| 4xc0 | ACP | Heat shock cognate 90 kDa protein | / | 0.554 | |
| 2hch | N5A | Endoplasmin | / | 0.552 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.552 | |
| 2hg1 | N5O | Endoplasmin | / | 0.549 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.549 | |
| 1u0z | RDC | Endoplasmin | / | 0.548 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.548 | |
| 2fyp | RDE | Endoplasmin | / | 0.547 | |
| 1qy5 | NEC | Endoplasmin | / | 0.546 | |
| 2gqp | PA7 | Endoplasmin | / | 0.546 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.544 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.544 | |
| 1u0y | PA7 | Endoplasmin | / | 0.541 | |
| 2gfd | RDA | Endoplasmin | / | 0.541 | |
| 2wep | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.539 | |
| 3r4n | FU5 | Heat shock protein HSP 90-alpha | / | 0.539 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.538 | |
| 3t2s | AGS | Heat shock protein HSP 90-alpha | / | 0.537 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.536 | |
| 3b28 | B2X | Heat shock protein HSP 90-alpha | / | 0.534 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.534 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.533 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.533 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.532 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.530 | |
| 2xx2 | 13C | ATP-dependent molecular chaperone HSP82 | / | 0.530 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.530 | |
| 4ce2 | BO5 | ATP-dependent molecular chaperone HSP82 | / | 0.530 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 3t10 | ACP | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.527 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.526 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.522 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 1am1 | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.520 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.520 | |
| 2xht | C0Y | Heat shock protein HSP 90-alpha | / | 0.520 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.519 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.516 | |
| 3t1k | ANP | Heat shock protein HSP 90-alpha | / | 0.516 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.515 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.515 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.513 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.513 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.512 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.509 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.509 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.509 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.507 | |
| 5f5r | ANP | Heat shock protein 75 kDa, mitochondrial | / | 0.507 | |
| 2wi5 | ZZ5 | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.502 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.501 | |
| 3ied | AN2 | HSP90 | / | 0.500 | |
| 4ivg | ANP | TNF receptor-associated protein 1 | / | 0.500 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.499 | |
| 3omu | IBD | Heat shock protein 83 | / | 0.497 | |
| 3t0z | ATP | Heat shock protein HSP 90-alpha | / | 0.497 | |
| 1bgq | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.496 | |
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.495 | |
| 2exl | GDM | Endoplasmin | / | 0.492 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.491 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.491 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.491 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 4gqt | ADP | Heat shock protein 90 | / | 0.488 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.487 | |
| 2vw5 | BC6 | ATP-dependent molecular chaperone HSP82 | / | 0.487 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.483 | |
| 1amw | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.481 | |
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.481 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.480 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.480 | |
| 2brc | CT5 | ATP-dependent molecular chaperone HSP82 | / | 0.479 | |
| 2o1v | ADP | Endoplasmin | / | 0.479 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.479 | |
| 3peh | IBD | Endoplasmin homolog, putative | / | 0.478 | |
| 2esa | GDM | Endoplasmin | / | 0.477 | |
| 3c11 | GDM | ATP-dependent molecular chaperone HSP82 | / | 0.477 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.477 | |
| 3d2r | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.476 | |
| 4ce3 | L4V | ATP-dependent molecular chaperone HSP82 | / | 0.476 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.475 | |
| 4egi | B2J | Heat shock protein HSP 90-alpha | / | 0.475 | |
| 2iwx | M1S | ATP-dependent molecular chaperone HSP82 | / | 0.474 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.474 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.473 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.471 | |
| 2qfo | A51 | Heat shock protein HSP 90-alpha | / | 0.470 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.470 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 2bu8 | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.468 | |
| 2vcj | 2EQ | Heat shock protein HSP 90-alpha | / | 0.468 | |
| 2o1u | ANP | Endoplasmin | / | 0.467 | |
| 3crl | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.466 | |
| 2wi1 | ZZ2 | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.465 | |
| 3h4l | ANP | DNA mismatch repair protein PMS1 | / | 0.464 | |
| 1dnp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.463 | |
| 1yt0 | ADP | Endoplasmin | / | 0.461 | |
| 2fxs | RDA | ATP-dependent molecular chaperone HSP82 | / | 0.461 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.458 | |
| 2xjx | XJX | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 2yi5 | YI5 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.455 | |
| 2bsm | BSM | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 4yau | 2AM | NADPH--cytochrome P450 reductase | / | 0.454 | |
| 2iws | NP4 | ATP-dependent molecular chaperone HSP82 | / | 0.453 | |
| 2yjw | YJW | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.453 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.452 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.452 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.451 | |
| 2bu2 | ATP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.450 | |
| 2jfg | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.449 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.449 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 2zdy | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.448 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.448 | |
| 4egk | RDC | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.447 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.446 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.446 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.445 | |
| 2cgf | P2N | ATP-dependent molecular chaperone HSP82 | / | 0.445 | |
| 2qfo | A13 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.445 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.444 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.444 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2hw1 | ANP | Ketohexokinase | / | 0.444 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.444 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.443 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.443 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3el5 | 1UN | Gag-Pol polyprotein | / | 0.442 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.441 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.441 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.440 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.440 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.440 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.440 |