sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3rkr | NAP | Uncharacterized protein |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3rkr | NAP | Uncharacterized protein | / | 1.000 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.513 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.510 | |
| 3sju | NDP | Keto reductase | / | 0.503 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.500 | |
| 4qed | NAP | ElxO | / | 0.500 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.497 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.493 | |
| 4qec | NAP | ElxO | / | 0.486 | |
| 1sny | NAP | LD36273p | / | 0.485 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.485 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.483 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.473 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.473 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.468 | |
| 3u4c | NDP | NADPH-dependent reductase BacG | / | 0.465 | |
| 4pvd | NDP | NADPH-dependent methylglyoxal reductase GRE2 | / | 0.465 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.464 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.461 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.461 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.460 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.460 | |
| 3muo | ZPR | Prolyl endopeptidase | / | 0.460 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.460 | |
| 1qyv | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 2yvw | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.458 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.456 | |
| 4xye | NAD | Formate dehydrogenase | / | 0.455 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 2v3a | FAD | Rubredoxin-NAD(+) reductase | 1.18.1.1 | 0.452 | |
| 4fry | NAD | Putative signal-transduction protein with CBS domains | / | 0.452 | |
| 3d2r | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.451 | |
| 4ohw | ATP | Protein clpf-1 | / | 0.449 | |
| 3pjt | C2E | Diguanylate cyclase/phosphodiesterase | / | 0.448 | |
| 1n7g | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.445 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.444 | |
| 4r4u | COA | Acyl-CoA thioesterase II | / | 0.444 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.443 | |
| 1udc | UFM | UDP-glucose 4-epimerase | 5.1.3.2 | 0.441 | |
| 3gyq | SAM | 23S rRNA (adenosine(1067)-2'-O)-methyltransferase | / | 0.441 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.441 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.441 | |
| 3s5w | NAP | L-ornithine N(5)-monooxygenase | / | 0.441 | |
| 1mgo | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 3sop | GDP | Neuronal-specific septin-3 | / | 0.440 | |
| 5ftf | ADP | TPR domain protein | / | 0.440 | |
| 5kj6 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 |