sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3rin | I2O | Mitogen-activated protein kinase 14 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3rin | I2O | Mitogen-activated protein kinase 14 | / | 1.000 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.662 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.651 | |
| 1zzl | TZY | Mitogen-activated protein kinase 14 | / | 0.578 | |
| 3fl4 | FL4 | Mitogen-activated protein kinase 14 | / | 0.566 | |
| 3fko | FKO | Mitogen-activated protein kinase 14 | / | 0.565 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.556 | |
| 3e92 | G6A | Mitogen-activated protein kinase 14 | / | 0.555 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.554 | |
| 3fmm | XI2 | Mitogen-activated protein kinase 14 | / | 0.551 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.549 | |
| 2gfs | PQB | Mitogen-activated protein kinase 14 | / | 0.538 | |
| 3gfe | P37 | Mitogen-activated protein kinase 14 | / | 0.532 | |
| 2zb1 | GK4 | Mitogen-activated protein kinase 14 | / | 0.529 | |
| 3fkn | FKN | Mitogen-activated protein kinase 14 | / | 0.529 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.519 | |
| 3uvq | FS8 | Mitogen-activated protein kinase 14 | / | 0.514 | |
| 2yix | YIX | Mitogen-activated protein kinase 14 | / | 0.513 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.507 | |
| 1wbw | LI4 | Mitogen-activated protein kinase 14 | / | 0.507 | |
| 3u8w | 09J | Mitogen-activated protein kinase 14 | / | 0.506 | |
| 3bx5 | 304 | Mitogen-activated protein kinase 14 | / | 0.501 | |
| 3mpa | SB2 | Mitogen-activated protein kinase 14 | / | 0.500 | |
| 3hp5 | 52P | Mitogen-activated protein kinase 14 | / | 0.494 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.493 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.490 | |
| 3fls | FLS | Mitogen-activated protein kinase 14 | / | 0.489 | |
| 1osv | CHC | Bile acid receptor | / | 0.486 | |
| 3vrz | VRZ | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.485 | |
| 4kip | 1R9 | Mitogen-activated protein kinase 14 | / | 0.484 | |
| 1zyj | BI5 | Mitogen-activated protein kinase 14 | / | 0.483 | |
| 3fkl | FKL | Mitogen-activated protein kinase 14 | / | 0.483 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.483 | |
| 2zb0 | GK3 | Mitogen-activated protein kinase 14 | / | 0.481 | |
| 3dt1 | P40 | Mitogen-activated protein kinase 14 | / | 0.480 | |
| 3l8x | N4D | Mitogen-activated protein kinase 14 | / | 0.480 | |
| 3b8r | 887 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.479 | |
| 2hk5 | 1BM | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.478 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.478 | |
| 3cp9 | C19 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.477 | |
| 3roc | 29A | Mitogen-activated protein kinase 14 | / | 0.476 | |
| 3uvp | 048 | Mitogen-activated protein kinase 14 | / | 0.476 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.474 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.474 | |
| 4aa5 | NQB | Mitogen-activated protein kinase 14 | / | 0.474 | |
| 4nks | 2M2 | Fibroblast growth factor receptor 1 | / | 0.473 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.472 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.471 | |
| 4dgg | I76 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.471 | |
| 4eh6 | 0ON | Mitogen-activated protein kinase 14 | / | 0.471 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.471 | |
| 3ha8 | 5JZ | Mitogen-activated protein kinase 14 | / | 0.470 | |
| 3mvl | 38P | Mitogen-activated protein kinase 14 | / | 0.470 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.470 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.470 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.470 | |
| 1ouy | 094 | Mitogen-activated protein kinase 14 | / | 0.469 | |
| 1ywr | LI9 | Mitogen-activated protein kinase 14 | / | 0.469 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 5iqf | GDP | Bifunctional AAC/APH | 2.3.1 | 0.467 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.466 | |
| 3fmj | FMJ | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 3tdv | GDP | Gentamicin resistance protein | / | 0.466 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.466 | |
| 3c5u | P41 | Mitogen-activated protein kinase 14 | / | 0.465 | |
| 4nka | 2K7 | Fibroblast growth factor receptor 1 | / | 0.465 | |
| 4otw | DB8 | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.465 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.465 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.464 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.464 | |
| 3fc1 | 52P | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 3qlf | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.464 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.464 | |
| 4pyt | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.464 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.463 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.462 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 3uib | SB2 | Putative mitogen-activated protein kinase | / | 0.462 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.462 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.461 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.460 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.459 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.459 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.459 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.458 | |
| 3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.458 | |
| 3vnt | 0JA | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.458 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.457 | |
| 1di9 | MSQ | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 1m7q | DQO | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 2p15 | EZT | Estrogen receptor | / | 0.456 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.456 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.456 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.456 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.456 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.455 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.455 | |
| 4kiq | 1RA | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.455 | |
| 4qmn | DB8 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.455 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.454 | |
| 3kf7 | L9G | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.454 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.454 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.453 | |
| 4ug2 | NGI | Adenosine receptor A2a | / | 0.453 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.452 | |
| 1pn3 | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.452 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.452 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.452 | |
| 3ac2 | KSE | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.451 | |
| 3ac5 | KZM | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.451 | |
| 3fsk | RO6 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.451 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2r8v | ACO | Amino-acid acetyltransferase | / | 0.450 | |
| 3hng | 8ST | Vascular endothelial growth factor receptor 1 | 2.7.10.1 | 0.450 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.450 | |
| 3a14 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.449 | |
| 3bhr | THG | Thymidylate synthase | / | 0.449 | |
| 3ce3 | 1FN | Hepatocyte growth factor receptor | 2.7.10.1 | 0.449 | |
| 3f69 | XDR | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.449 | |
| 4rph | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.449 | |
| 1wwk | NAD | 307aa long hypothetical phosphoglycerate dehydrogenase | / | 0.448 | |
| 2itu | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.448 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.448 | |
| 3iw5 | DF3 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.448 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.448 | |
| 4xrg | NAD | Homospermidine synthase | 2.5.1.44 | 0.448 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.447 | |
| 1ii6 | ADP | Kinesin-like protein KIF11 | / | 0.447 | |
| 1qcf | PP1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.447 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.447 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.447 | |
| 3nww | 3NW | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.447 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4kcf | AKM | FAD-dependent oxidoreductase | / | 0.447 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 1kk4 | ACO | Streptogramin A acetyltransferase | 2.3.1 | 0.446 | |
| 2g76 | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.446 | |
| 2og8 | 1N8 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.446 | |
| 2qd9 | LGF | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 2zyb | KSL | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.446 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4aa4 | QC0 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.446 | |
| 5doz | NDP | JamJ | / | 0.446 | |
| 1tys | DHF | Thymidylate synthase | / | 0.445 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2nu9 | COA | Succinate--CoA ligase [ADP-forming] subunit alpha | 6.2.1.5 | 0.445 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.445 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3lpf | Z77 | Beta-glucuronidase | 3.2.1.31 | 0.445 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.445 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.444 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.444 | |
| 2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3fly | FLY | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3mpt | 1GK | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 4ase | AV9 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.444 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4mq1 | 2C3 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.444 | |
| 4pd6 | URI | Nucleoside permease | / | 0.444 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.443 | |
| 3fmn | 530 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.443 | |
| 4f64 | 0S8 | Fibroblast growth factor receptor 1 | / | 0.443 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.443 | |
| 4i09 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.443 | |
| 1f4g | TP4 | Thymidylate synthase | / | 0.442 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.442 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.442 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2j0v | GDP | Rac-like GTP-binding protein ARAC7 | / | 0.442 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.442 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.442 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.442 | |
| 3vo3 | 0KF | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.442 | |
| 4ma6 | 28E | Ara h 8 allergen | / | 0.442 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.441 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.441 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 3flz | FLZ | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.441 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.441 | |
| 4nr4 | 2LK | CREB-binding protein | / | 0.441 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.441 | |
| 1dss | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.440 | |
| 1knu | YPA | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.440 | |
| 2bal | PQA | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 2itn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.440 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.440 | |
| 4aac | AAV | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4b12 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4kin | 1M8 | Mitogen-activated protein kinase 14 | / | 0.440 |