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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3rhlNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.6

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3rhlNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.61.000
3rhrNDPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.709
3rhjNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.580
3rhqNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.518
1uxvNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.512
1a4zNADAldehyde dehydrogenase, mitochondrial1.2.1.30.490
4i8pNADAminoaldehyde dehydrogenase 1/0.487
1ky8NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.482
3lnsNAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.481
1uxrNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.473
1uxuNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.472
4gnzNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.467
3efvNADPutative succinate-semialdehyde dehydrogenase/0.461
2j6lNAIAlpha-aminoadipic semialdehyde dehydrogenase1.2.1.310.451
4qa0SHHHistone deacetylase 83.5.1.980.450
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2ph5NADHomospermidine synthase/0.442
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.440