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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3rhjNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.6

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3rhjNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.61.000
3rhlNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.566
3rhrNDPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.561
3rhqNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.520
1uxvNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.495
4pz2NADAldehyde dehydrogenase 2-6/0.490
3eai328Nitric oxide synthase, inducible1.14.13.390.485
1o04NADAldehyde dehydrogenase, mitochondrial1.2.1.30.477
4i8pNADAminoaldehyde dehydrogenase 1/0.470
1o01NADAldehyde dehydrogenase, mitochondrial1.2.1.30.467
1uxrNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.462
2onpNADAldehyde dehydrogenase, mitochondrial1.2.1.30.461
1ky8NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.460
3hazNADBifunctional protein PutA/0.457
1uxuNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.456
4gnzNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.456
3lnsNAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.454
2onmNADAldehyde dehydrogenase, mitochondrial1.2.1.30.450
5dibNADBetaine-aldehyde dehydrogenase/0.450
1a4zNADAldehyde dehydrogenase, mitochondrial1.2.1.30.449
1wnbNAIGamma-aminobutyraldehyde dehydrogenase1.2.1.190.449
3ebf332Nitric oxide synthase, inducible1.14.13.390.448
4pxnNADAldehyde dehydrogenase family 7 member B4/0.442