scPDB - Distribution of Binding site Similarity values of 3rg9 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3rg9	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3rg9	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	1.000
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.621
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.551
3eej	53R	Uncharacterized protein	/	0.551
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.546
3cse	N22	Uncharacterized protein	/	0.536
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.536
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.534
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.534
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.532
3eem	53V	Uncharacterized protein	/	0.529
3eek	53S	Uncharacterized protein	/	0.528
1dyr	TOP	Dihydrofolate reductase	1.5.1.3	0.526
3qly	55V	Uncharacterized protein	/	0.525
4h98	14Q	Uncharacterized protein	/	0.520
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.515
3qlx	QLR	Uncharacterized protein	/	0.515
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.511
2w3w	VG9	Dihydrofolate reductase	/	0.508
3eel	53T	Uncharacterized protein	/	0.505
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.505
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.503
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.502
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.502
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.499
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.496
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.496
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.491
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.488
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.487
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.486
3qlz	QLZ	Uncharacterized protein	/	0.486
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.485
2w3v	TOP	Dihydrofolate reductase	/	0.485
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.485
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.485
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.485
3i8a	N22	Dihydrofolate reductase	1.5.1.3	0.484
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.484
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.482
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.479
1s3w	TQT	Dihydrofolate reductase	1.5.1.3	0.479
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.477
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.477
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.477
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.476
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.475
3um8	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.475
1ao8	MTX	Dihydrofolate reductase	1.5.1.3	0.473
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.473
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.472
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.472
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.472
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.472
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.471
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.471
1ia1	TQ3	Dihydrofolate reductase	1.5.1.3	0.470
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.469
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.468
2blb	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.468
2zza	FOL	Dihydrofolate reductase	/	0.468
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.468
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.467
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.467
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.467
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.467
3nxo	D2B	Dihydrofolate reductase	1.5.1.3	0.467
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.465
3srq	Q19	Dihydrofolate reductase	1.5.1.3	0.465
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.464
1rx8	FOL	Dihydrofolate reductase	1.5.1.3	0.463
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.462
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	0.462
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.462
3vrw	YS5	Vitamin D3 receptor	/	0.462
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.462
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.461
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.459
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.459
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.458
2jed	LG8	Protein kinase C theta type	2.7.11.13	0.458
3sai	9DR	Dihydrofolate reductase	/	0.457
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.456
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.456
3pm0	BHF	Cytochrome P450 1B1	/	0.455
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.454
3irn	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.454
1lud	TRR	Dihydrofolate reductase	1.5.1.3	0.453
3sa1	6DR	Dihydrofolate reductase	/	0.453
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.453
3dg8	RJ6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.452
3l9l	L9L	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.452
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.452
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.450
1s0z	EB1	Vitamin D3 receptor	/	0.448
3sa2	7DR	Dihydrofolate reductase	/	0.448
4p66	MTX	Dihydrofolate reductase	/	0.448
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.447
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.447
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.446
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.446
1mc5	AHE	Alcohol dehydrogenase class-3	1.1.1.1	0.445
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.445
1wxy	FRK	Adenosine deaminase	3.5.4.4	0.445
3n61	XFJ	Nitric oxide synthase, brain	1.14.13.39	0.444
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.444
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.443
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.442
2p15	EZT	Estrogen receptor	/	0.442
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.442
4kjj	FOL	Dihydrofolate reductase	1.5.1.3	0.442
1qiq	ACC	Isopenicillin N synthase	1.21.3.1	0.441
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.441
2hcd	BIV	Vitamin D3 receptor A	/	0.440
4iaq	2GM	5-hydroxytryptamine receptor 1B	/	0.440