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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3rc7TLOSugar 3-ketoreductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3rc7TLOSugar 3-ketoreductase/1.000
1euyQSIGlutamine--tRNA ligase6.1.1.180.484
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.483
3rc9TLOSugar 3-ketoreductase/0.480
2wvlGDDMannosyl-3-phosphogylcerate synthase/0.473
3tdkUPGUDP-glucose 6-dehydrogenase1.1.1.220.473
2rd2QSIGlutamine--tRNA ligase6.1.1.180.470
3kxoKXOHematopoietic prostaglandin D synthase/0.468
2re8GSUGlutamine--tRNA ligase6.1.1.180.466
2oz57XYUncharacterized protein/0.464
2q0gUPUPoly(A) polymerase, putative/0.462
2vcqD25Hematopoietic prostaglandin D synthase/0.460
3jt3H4BNitric oxide synthase, brain1.14.13.390.459
3apwDP0Alpha-1-acid glycoprotein 2/0.457
3af0GDPPantothenate kinase2.7.1.330.456
3jtaH4BNitric oxide synthase, brain1.14.13.390.456
3ptzUDXUDP-glucose 6-dehydrogenase1.1.1.220.456
1zzqDP9Nitric oxide synthase, brain1.14.13.390.453
3stdMQ0Scytalone dehydratase4.2.1.940.453
4jyzATPGlutamine--tRNA ligase6.1.1.180.453
2h63NAPBiliverdin reductase A1.3.1.240.450
4dya0MFNucleoprotein/0.450
1o02NADAldehyde dehydrogenase, mitochondrial1.2.1.30.449
1rs6DP2Nitric oxide synthase, brain1.14.13.390.449
3to3ATPPetrobactin biosynthesis protein AsbB/0.449
3c74ANUUridine phosphorylase2.4.2.30.447
1yunATPProbable nicotinate-nucleotide adenylyltransferase2.7.7.180.446
3jt6H4BNitric oxide synthase, brain1.14.13.390.446
3q99H4BNitric oxide synthase, brain1.14.13.390.445
1akcPPEAspartate aminotransferase, mitochondrial2.6.1.10.444
2g6iHBINitric oxide synthase, brain1.14.13.390.444
2wgs1AZGlutamine synthetase6.3.1.20.444
3jt4H4BNitric oxide synthase, brain1.14.13.390.444
5cfpC2EStimulator of interferon genes protein/0.444
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.10.442
1fmlRTLRetinol dehydratase/0.442
3cr7PPSAdenylyl-sulfate kinase2.7.1.250.442
4cthRDFNeprilysin/0.442
4cx5H4BNitric oxide synthase, brain1.14.13.390.442
5aglH4BNitric oxide synthase, brain1.14.13.390.442
4h9tHL4Phosphotriesterase/0.441
4m2bUPGUDP-glucose pyrophosphorylase/0.441
5agkH4BNitric oxide synthase, brain1.14.13.390.441
2bo8GDXMannosylglycerate synthase/0.440
3pngH4BNitric oxide synthase, brain1.14.13.390.440
3ufoH4BNitric oxide synthase, brain1.14.13.390.440
4dbc3QPAspartate aminotransferase2.6.1.10.440
4fvyH4BNitric oxide synthase, brain1.14.13.390.440