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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3rak03ZCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3rak03ZCyclin-dependent kinase 22.7.11.221.000
3s1h56ZCyclin-dependent kinase 22.7.11.220.851
3ral04ZCyclin-dependent kinase 22.7.11.220.702
3rmf20ZCyclin-dependent kinase 22.7.11.220.614
3sw418KCyclin-dependent kinase 22.7.11.220.605
3qxpX64Cyclin-dependent kinase 22.7.11.220.597
3sqq99ZCyclin-dependent kinase 22.7.11.220.596
3rpv26ZCyclin-dependent kinase 22.7.11.220.591
3r9dX6BCyclin-dependent kinase 22.7.11.220.583
2w05FRTCyclin-dependent kinase 22.7.11.220.581
3qtxX43Cyclin-dependent kinase 22.7.11.220.573
1y91CT9Cyclin-dependent kinase 22.7.11.220.571
2w17I19Cyclin-dependent kinase 22.7.11.220.569
4fkr45KCyclin-dependent kinase 22.7.11.220.559
4acm7YGCyclin-dependent kinase 22.7.11.220.556
3qtrX36Cyclin-dependent kinase 22.7.11.220.555
3sw719KCyclin-dependent kinase 22.7.11.220.549
3rk708ZCyclin-dependent kinase 22.7.11.220.542
4fkv61KCyclin-dependent kinase 22.7.11.220.542
2fvdLIACyclin-dependent kinase 22.7.11.220.541
2w06FRVCyclin-dependent kinase 22.7.11.220.539
3rjc06ZCyclin-dependent kinase 22.7.11.220.539
1fvv107Cyclin-dependent kinase 22.7.11.220.538
2xmyCDKCyclin-dependent kinase 22.7.11.220.538
3qqkX02Cyclin-dependent kinase 22.7.11.220.538
3qtzX42Cyclin-dependent kinase 22.7.11.220.538
3uli1N3Cyclin-dependent kinase 22.7.11.220.537
4fkw62KCyclin-dependent kinase 22.7.11.220.537
2r3lSCWCyclin-dependent kinase 22.7.11.220.536
4fko20KCyclin-dependent kinase 22.7.11.220.536
1urwI1PCyclin-dependent kinase 22.7.11.220.535
2vu3LZECyclin-dependent kinase 22.7.11.220.535
3qu0X40Cyclin-dependent kinase 22.7.11.220.533
3r1sX73Cyclin-dependent kinase 22.7.11.220.532
1gih1PUCyclin-dependent kinase 22.7.11.220.530
1p2a5BNCyclin-dependent kinase 22.7.11.220.525
3rpy27ZCyclin-dependent kinase 22.7.11.220.525
4bgh3I6Cyclin-dependent kinase 22.7.11.220.525
3rni21ZCyclin-dependent kinase 22.7.11.220.524
3unk0BYCyclin-dependent kinase 22.7.11.220.524
3qtuX44Cyclin-dependent kinase 22.7.11.220.523
2uznC96Cyclin-dependent kinase 22.7.11.220.522
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.521
3rk507ZCyclin-dependent kinase 22.7.11.220.518
2b52D42Cyclin-dependent kinase 22.7.11.220.517
2c6iDT1Cyclin-dependent kinase 22.7.11.220.516
1v1k3FPCyclin-dependent kinase 22.7.11.220.515
2r3kSCQCyclin-dependent kinase 22.7.11.220.515
2vv9IM9Cyclin-dependent kinase 22.7.11.220.515
4fx360KCyclin-dependent kinase 22.7.11.220.515
1g5sI17Cyclin-dependent kinase 22.7.11.220.514
1oiyN41Cyclin-dependent kinase 22.7.11.220.514
3r9oZ71Cyclin-dependent kinase 22.7.11.220.512
1pxmCK5Cyclin-dependent kinase 22.7.11.220.509
2iw84SPCyclin-dependent kinase 22.7.11.220.509
2vttLZDCyclin-dependent kinase 22.7.11.220.509
3rkb12ZCyclin-dependent kinase 22.7.11.220.509
1oi9N20Cyclin-dependent kinase 22.7.11.220.508
3py0SU9Cyclin-dependent kinase 22.7.11.220.508
1w0xOLOCyclin-dependent kinase 22.7.11.220.505
2a0cCK9Cyclin-dependent kinase 22.7.11.220.503
3qxoX65Cyclin-dependent kinase 22.7.11.220.503
1di8DTQCyclin-dependent kinase 22.7.11.220.502
3r9hZ67Cyclin-dependent kinase 22.7.11.220.502
3r7uX96Cyclin-dependent kinase 22.7.11.220.500
3qzgX67Cyclin-dependent kinase 22.7.11.220.499
3unj0BXCyclin-dependent kinase 22.7.11.220.499
2c6o4SPCyclin-dependent kinase 22.7.11.220.498
2r3p3SCCyclin-dependent kinase 22.7.11.220.498
3qruX19Cyclin-dependent kinase 22.7.11.220.498
1oitHDTCyclin-dependent kinase 22.7.11.220.497
3ti1B49Cyclin-dependent kinase 22.7.11.220.497
1pkdUCNCyclin-dependent kinase 22.7.11.220.496
1ke9LS5Cyclin-dependent kinase 22.7.11.220.494
2w1hL0FCyclin-dependent kinase 22.7.11.220.494
3r71X86Cyclin-dependent kinase 22.7.11.220.494
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.493
3qzhX69Cyclin-dependent kinase 22.7.11.220.493
3rk909ZCyclin-dependent kinase 22.7.11.220.493
4fkt48KCyclin-dependent kinase 22.7.11.220.493
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.492
4fkq42KCyclin-dependent kinase 22.7.11.220.492
1ke5LS1Cyclin-dependent kinase 22.7.11.220.491
1pyePM1Cyclin-dependent kinase 22.7.11.220.490
1gii1PUCyclin-dependent kinase 22.7.11.220.489
1ke6LS2Cyclin-dependent kinase 22.7.11.220.489
3r73X87Cyclin-dependent kinase 22.7.11.220.489
4erwSTUCyclin-dependent kinase 22.7.11.220.488
4fks46KCyclin-dependent kinase 22.7.11.220.487
3at4CCKCasein kinase II subunit alpha2.7.11.10.486
2uzoC62Cyclin-dependent kinase 22.7.11.220.483
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.482
3s0o50ZCyclin-dependent kinase 22.7.11.220.482
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.482
3lfnA27Cyclin-dependent kinase 22.7.11.220.481
4qmpDKISerine/threonine-protein kinase 242.7.11.10.481
1h1r6CPCyclin-dependent kinase 22.7.11.220.478
1ke7LS3Cyclin-dependent kinase 22.7.11.220.478
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.478
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.478
2c6lDT4Cyclin-dependent kinase 22.7.11.220.477
3be9P04Casein kinase II subunit alpha2.7.11.10.477
2r3o2SCCyclin-dependent kinase 22.7.11.220.476
4ez50RSCyclin-dependent kinase 62.7.11.220.476
1oguST8Cyclin-dependent kinase 22.7.11.220.475
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.474
2wihP48Cyclin-dependent kinase 22.7.11.220.474
2wxvWXVCyclin-dependent kinase 22.7.11.220.474
3ddpRC8Cyclin-dependent kinase 22.7.11.220.474
4fkj11KCyclin-dependent kinase 22.7.11.220.474
1oiqHDUCyclin-dependent kinase 22.7.11.220.473
2b55D31Cyclin-dependent kinase 22.7.11.220.473
4eok4SPCyclin-dependent kinase 22.7.11.220.473
1e9hINRCyclin-dependent kinase 22.7.11.220.472
3r8zZ63Cyclin-dependent kinase 22.7.11.220.472
3ezvEZVCyclin-dependent kinase 22.7.11.220.471
3qrtX14Cyclin-dependent kinase 22.7.11.220.471
3r8lZ30Cyclin-dependent kinase 22.7.11.220.471
3pxyJWSCyclin-dependent kinase 22.7.11.220.470
3r7iX9ICyclin-dependent kinase 22.7.11.220.470
3r8pZ46Cyclin-dependent kinase 22.7.11.220.470
2bheBRYCyclin-dependent kinase 22.7.11.220.469
2uzbC75Cyclin-dependent kinase 22.7.11.220.469
3rm618ZCyclin-dependent kinase 22.7.11.220.469
3qtwX3ACyclin-dependent kinase 22.7.11.220.468
4bcmT7ZCyclin-dependent kinase 22.7.11.220.468
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.468
3ql8X01Cyclin-dependent kinase 22.7.11.220.467
1aq1STUCyclin-dependent kinase 22.7.11.220.466
2pvnP63Casein kinase II subunit alpha2.7.11.10.465
4ii5ADPCyclin-dependent kinase 22.7.11.220.465
1h1s4SPCyclin-dependent kinase 22.7.11.220.464
3roy22ZCyclin-dependent kinase 22.7.11.220.464
2cchATPCyclin-dependent kinase 22.7.11.220.463
2eufLQQCyclin-dependent kinase 62.7.11.220.463
2vtsLZCCyclin-dependent kinase 22.7.11.220.463
3s2pPMUCyclin-dependent kinase 22.7.11.220.463
3rm719ZCyclin-dependent kinase 22.7.11.220.462
3tnwF18Cyclin-dependent kinase 22.7.11.220.462
3zep1NXTyrosine-protein kinase JAK32.7.10.20.462
1ke8LS4Cyclin-dependent kinase 22.7.11.220.460
2iw94SPCyclin-dependent kinase 22.7.11.220.460
3iggEFQCyclin-dependent kinase 22.7.11.220.460
4aqc88ATyrosine-protein kinase JAK2/0.460
4ek816KCyclin-dependent kinase 22.7.11.220.460
1gij2PUCyclin-dependent kinase 22.7.11.220.459
2r64740Cyclin-dependent kinase 22.7.11.220.459
4ez30S0Cyclin-dependent kinase 22.7.11.220.459
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.459
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
4btjATPTau-tubulin kinase 12.7.11.10.458
1dm2HMDCyclin-dependent kinase 22.7.11.220.457
3ig7EFPCyclin-dependent kinase 22.7.11.220.457
3pj8404Cyclin-dependent kinase 22.7.11.220.457
4fkpLS5Cyclin-dependent kinase 22.7.11.220.457
1pxpCK8Cyclin-dependent kinase 22.7.11.220.456
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.456
3lfsA07Cyclin-dependent kinase 22.7.11.220.456
3qqfX07Cyclin-dependent kinase 22.7.11.220.456
3qtqX35Cyclin-dependent kinase 22.7.11.220.456
2bhhRYUCyclin-dependent kinase 22.7.11.220.455
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.455
2vtqLZACyclin-dependent kinase 22.7.11.220.455
3ddqRRCCyclin-dependent kinase 22.7.11.220.455
3qwkX62Cyclin-dependent kinase 22.7.11.220.455
3r7yZ04Cyclin-dependent kinase 22.7.11.220.455
3wblPDYCyclin-dependent kinase 22.7.11.220.455
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.455
1fvt106Cyclin-dependent kinase 22.7.11.220.454
2r3jSCJCyclin-dependent kinase 22.7.11.220.454
3qwjX6ACyclin-dependent kinase 22.7.11.220.454
3rpo24ZCyclin-dependent kinase 22.7.11.220.454
2i40BLZCyclin-dependent kinase 22.7.11.220.453
2uzdC85Cyclin-dependent kinase 22.7.11.220.453
2wpa889Cyclin-dependent kinase 22.7.11.220.453
3r6xX84Cyclin-dependent kinase 22.7.11.220.453
3ggfGVDSerine/threonine-protein kinase 26/0.452
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.452
3r7vZ02Cyclin-dependent kinase 22.7.11.220.452
4bbfO19Tyrosine-protein kinase JAK2/0.452
4bcnT9NCyclin-dependent kinase 22.7.11.220.452
4eomATPCyclin-dependent kinase 22.7.11.220.452
2btsU32Cyclin-dependent kinase 22.7.11.220.451
3raiX85Cyclin-dependent kinase 22.7.11.220.451
4fv9E71Mitogen-activated protein kinase 12.7.11.240.451
1pxlCK4Cyclin-dependent kinase 22.7.11.220.450
2r3mSCXCyclin-dependent kinase 22.7.11.220.450
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.450
2x1nX1NCyclin-dependent kinase 22.7.11.220.450
3lfqA28Cyclin-dependent kinase 22.7.11.220.450
1w8cN69Cyclin-dependent kinase 22.7.11.220.449
2r3gSC9Cyclin-dependent kinase 22.7.11.220.449
3fz1B98Cyclin-dependent kinase 22.7.11.220.449
4hge15VTyrosine-protein kinase JAK2/0.449
1y8yCT7Cyclin-dependent kinase 22.7.11.220.448
2c69CT8Cyclin-dependent kinase 22.7.11.220.448
3i60E86Mitogen-activated protein kinase 12.7.11.240.448
4bcpT3CCyclin-dependent kinase 22.7.11.220.448
1oiuN76Cyclin-dependent kinase 22.7.11.220.447
2r3fSC8Cyclin-dependent kinase 22.7.11.220.447
1ykr628Cyclin-dependent kinase 22.7.11.220.446
2xnbY8LCyclin-dependent kinase 22.7.11.220.446
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.446
3nux3NVCyclin-dependent kinase 62.7.11.220.446
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.445
3r83Z14Cyclin-dependent kinase 22.7.11.220.445
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.445
2btrU73Cyclin-dependent kinase 22.7.11.220.444
2pvhP19Casein kinase II subunit alpha2.7.11.10.444
2r3iSCFCyclin-dependent kinase 22.7.11.220.444
2r3r6SCCyclin-dependent kinase 22.7.11.220.444
3qtsX46Cyclin-dependent kinase 22.7.11.220.444
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.444
3u4uLNHCasein kinase II subunit alpha2.7.11.10.444
3zh8C58Protein kinase C iota type2.7.11.130.444
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.443
4gmy0X5Tyrosine-protein kinase JAK2/0.443
4lyn1YGCyclin-dependent kinase 22.7.11.220.443
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.443
1h1pCMGCyclin-dependent kinase 22.7.11.220.442
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.442
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.442
4dgnLU2Casein kinase II subunit alpha2.7.11.10.442
2c6tDT5Cyclin-dependent kinase 22.7.11.220.441
3eb0DRKUncharacterized protein/0.441
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.441
2duv371Cyclin-dependent kinase 22.7.11.220.440
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.440
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.440
4anmWULCasein kinase II subunit alpha2.7.11.10.440