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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3r28XA0Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3r28XA0Cyclin-dependent kinase 22.7.11.221.000
3roy22ZCyclin-dependent kinase 22.7.11.220.738
3r6xX84Cyclin-dependent kinase 22.7.11.220.704
3r1qX75Cyclin-dependent kinase 22.7.11.220.697
3qwkX62Cyclin-dependent kinase 22.7.11.220.619
3qwjX6ACyclin-dependent kinase 22.7.11.220.615
3rk909ZCyclin-dependent kinase 22.7.11.220.615
3r1sX73Cyclin-dependent kinase 22.7.11.220.601
3qzhX69Cyclin-dependent kinase 22.7.11.220.599
3qu0X40Cyclin-dependent kinase 22.7.11.220.598
3r9hZ67Cyclin-dependent kinase 22.7.11.220.595
3raiX85Cyclin-dependent kinase 22.7.11.220.594
3r7yZ04Cyclin-dependent kinase 22.7.11.220.593
1ckpPVBCyclin-dependent kinase 22.7.11.220.591
3qxoX65Cyclin-dependent kinase 22.7.11.220.589
3qqfX07Cyclin-dependent kinase 22.7.11.220.588
3rpo24ZCyclin-dependent kinase 22.7.11.220.588
2fvdLIACyclin-dependent kinase 22.7.11.220.586
3r73X87Cyclin-dependent kinase 22.7.11.220.579
3r7vZ02Cyclin-dependent kinase 22.7.11.220.579
3qziX72Cyclin-dependent kinase 22.7.11.220.577
3rkb12ZCyclin-dependent kinase 22.7.11.220.577
3qzgX67Cyclin-dependent kinase 22.7.11.220.576
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.574
3r7eX88Cyclin-dependent kinase 22.7.11.220.571
3qtuX44Cyclin-dependent kinase 22.7.11.220.569
3lfnA27Cyclin-dependent kinase 22.7.11.220.567
3rm719ZCyclin-dependent kinase 22.7.11.220.567
3s0o50ZCyclin-dependent kinase 22.7.11.220.567
3iggEFQCyclin-dependent kinase 22.7.11.220.565
3rm618ZCyclin-dependent kinase 22.7.11.220.565
2r64740Cyclin-dependent kinase 22.7.11.220.560
3qx2X63Cyclin-dependent kinase 22.7.11.220.558
1ke6LS2Cyclin-dependent kinase 22.7.11.220.556
2a4lRRCCyclin-dependent kinase 22.7.11.220.556
3qruX19Cyclin-dependent kinase 22.7.11.220.556
3ddpRC8Cyclin-dependent kinase 22.7.11.220.554
1v1k3FPCyclin-dependent kinase 22.7.11.220.553
4fki09KCyclin-dependent kinase 22.7.11.220.553
3s2pPMUCyclin-dependent kinase 22.7.11.220.551
2a0cCK9Cyclin-dependent kinase 22.7.11.220.547
2w06FRVCyclin-dependent kinase 22.7.11.220.547
3r9dX6BCyclin-dependent kinase 22.7.11.220.547
2btrU73Cyclin-dependent kinase 22.7.11.220.544
2vu3LZECyclin-dependent kinase 22.7.11.220.544
3unk0BYCyclin-dependent kinase 22.7.11.220.544
3r83Z14Cyclin-dependent kinase 22.7.11.220.543
3r8lZ30Cyclin-dependent kinase 22.7.11.220.543
3r8pZ46Cyclin-dependent kinase 22.7.11.220.543
1fvt106Cyclin-dependent kinase 22.7.11.220.542
1g5sI17Cyclin-dependent kinase 22.7.11.220.542
4lyn1YGCyclin-dependent kinase 22.7.11.220.541
1di8DTQCyclin-dependent kinase 22.7.11.220.540
2btsU32Cyclin-dependent kinase 22.7.11.220.540
3qtxX43Cyclin-dependent kinase 22.7.11.220.540
1w0xOLOCyclin-dependent kinase 22.7.11.220.539
3r8uZ31Cyclin-dependent kinase 22.7.11.220.539
3rjc06ZCyclin-dependent kinase 22.7.11.220.539
4ez30S0Cyclin-dependent kinase 22.7.11.220.539
2c6o4SPCyclin-dependent kinase 22.7.11.220.538
3r7iX9ICyclin-dependent kinase 22.7.11.220.538
3rk708ZCyclin-dependent kinase 22.7.11.220.538
4fkq42KCyclin-dependent kinase 22.7.11.220.538
1oitHDTCyclin-dependent kinase 22.7.11.220.535
3rpv26ZCyclin-dependent kinase 22.7.11.220.535
3sqq99ZCyclin-dependent kinase 22.7.11.220.535
1pxmCK5Cyclin-dependent kinase 22.7.11.220.534
4ek610KCyclin-dependent kinase 22.7.11.220.534
1w8cN69Cyclin-dependent kinase 22.7.11.220.533
3rni21ZCyclin-dependent kinase 22.7.11.220.533
2iw94SPCyclin-dependent kinase 22.7.11.220.532
2b55D31Cyclin-dependent kinase 22.7.11.220.531
1h1s4SPCyclin-dependent kinase 22.7.11.220.530
2r3gSC9Cyclin-dependent kinase 22.7.11.220.530
3r8vZ62Cyclin-dependent kinase 22.7.11.220.528
1ke7LS3Cyclin-dependent kinase 22.7.11.220.527
1ykr628Cyclin-dependent kinase 22.7.11.220.527
3r7uX96Cyclin-dependent kinase 22.7.11.220.527
1ke5LS1Cyclin-dependent kinase 22.7.11.220.526
1oiyN41Cyclin-dependent kinase 22.7.11.220.525
1vyzN5BCyclin-dependent kinase 22.7.11.220.525
1h1r6CPCyclin-dependent kinase 22.7.11.220.524
2j9mPY8Cyclin-dependent kinase 22.7.11.220.524
4fkpLS5Cyclin-dependent kinase 22.7.11.220.524
3ddqRRCCyclin-dependent kinase 22.7.11.220.523
3qqlX03Cyclin-dependent kinase 22.7.11.220.523
3r1yX76Cyclin-dependent kinase 22.7.11.220.523
3rahO1ZCyclin-dependent kinase 22.7.11.220.523
2w05FRTCyclin-dependent kinase 22.7.11.220.522
3ezrEZRCyclin-dependent kinase 22.7.11.220.522
3ql8X01Cyclin-dependent kinase 22.7.11.220.522
4kd11QKCyclin-dependent kinase 22.7.11.220.522
1oguST8Cyclin-dependent kinase 22.7.11.220.521
3qtzX42Cyclin-dependent kinase 22.7.11.220.521
3s1h56ZCyclin-dependent kinase 22.7.11.220.521
1oi9N20Cyclin-dependent kinase 22.7.11.220.519
2r3p3SCCyclin-dependent kinase 22.7.11.220.519
2uzoC62Cyclin-dependent kinase 22.7.11.220.519
3qrtX14Cyclin-dependent kinase 22.7.11.220.519
4bgh3I6Cyclin-dependent kinase 22.7.11.220.519
4erwSTUCyclin-dependent kinase 22.7.11.220.519
3ezvEZVCyclin-dependent kinase 22.7.11.220.518
2r3o2SCCyclin-dependent kinase 22.7.11.220.517
4eor4SPCyclin-dependent kinase 22.7.11.220.517
1pxkCK3Cyclin-dependent kinase 22.7.11.220.516
2b52D42Cyclin-dependent kinase 22.7.11.220.516
2c4g514Cyclin-dependent kinase 22.7.11.220.516
3qtqX35Cyclin-dependent kinase 22.7.11.220.516
3rak03ZCyclin-dependent kinase 22.7.11.220.516
4fkj11KCyclin-dependent kinase 22.7.11.220.516
1ke8LS4Cyclin-dependent kinase 22.7.11.220.515
2r3r6SCCyclin-dependent kinase 22.7.11.220.515
3qqhX0ACyclin-dependent kinase 22.7.11.220.515
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.514
3ig7EFPCyclin-dependent kinase 22.7.11.220.514
1gih1PUCyclin-dependent kinase 22.7.11.220.513
1ke9LS5Cyclin-dependent kinase 22.7.11.220.513
1vyw292Cyclin-dependent kinase 22.7.11.220.513
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.513
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.513
4fkr45KCyclin-dependent kinase 22.7.11.220.512
2iw84SPCyclin-dependent kinase 22.7.11.220.511
1oiqHDUCyclin-dependent kinase 22.7.11.220.510
2c69CT8Cyclin-dependent kinase 22.7.11.220.510
2r3kSCQCyclin-dependent kinase 22.7.11.220.510
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.510
3pj8404Cyclin-dependent kinase 22.7.11.220.510
2duv371Cyclin-dependent kinase 22.7.11.220.509
3qqkX02Cyclin-dependent kinase 22.7.11.220.509
3wblPDYCyclin-dependent kinase 22.7.11.220.509
4ek816KCyclin-dependent kinase 22.7.11.220.509
3r71X86Cyclin-dependent kinase 22.7.11.220.508
3s00Z60Cyclin-dependent kinase 22.7.11.220.508
4bcpT3CCyclin-dependent kinase 22.7.11.220.508
1gii1PUCyclin-dependent kinase 22.7.11.220.507
3rk507ZCyclin-dependent kinase 22.7.11.220.506
4eok4SPCyclin-dependent kinase 22.7.11.220.506
2wpa889Cyclin-dependent kinase 22.7.11.220.505
3my5RFZCyclin-dependent kinase 22.7.11.220.505
2r3lSCWCyclin-dependent kinase 22.7.11.220.503
1p2a5BNCyclin-dependent kinase 22.7.11.220.501
1urwI1PCyclin-dependent kinase 22.7.11.220.501
1h0w207Cyclin-dependent kinase 22.7.11.220.500
3qxpX64Cyclin-dependent kinase 22.7.11.220.500
2xmyCDKCyclin-dependent kinase 22.7.11.220.499
3lfsA07Cyclin-dependent kinase 22.7.11.220.499
4cfnJYMCyclin-dependent kinase 22.7.11.220.499
2uznC96Cyclin-dependent kinase 22.7.11.220.497
3unj0BXCyclin-dependent kinase 22.7.11.220.496
2bhhRYUCyclin-dependent kinase 22.7.11.220.495
2w1hL0FCyclin-dependent kinase 22.7.11.220.495
3rpr25ZCyclin-dependent kinase 22.7.11.220.495
4bcmT7ZCyclin-dependent kinase 22.7.11.220.495
2c6mDT5Cyclin-dependent kinase 22.7.11.220.494
3ral04ZCyclin-dependent kinase 22.7.11.220.494
3py0SU9Cyclin-dependent kinase 22.7.11.220.493
1pxlCK4Cyclin-dependent kinase 22.7.11.220.492
2i40BLZCyclin-dependent kinase 22.7.11.220.491
3qx4X4BCyclin-dependent kinase 22.7.11.220.491
1aq1STUCyclin-dependent kinase 22.7.11.220.490
1e9hINRCyclin-dependent kinase 22.7.11.220.490
3sw418KCyclin-dependent kinase 22.7.11.220.490
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.489
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.488
1oiuN76Cyclin-dependent kinase 22.7.11.220.487
1pyePM1Cyclin-dependent kinase 22.7.11.220.487
1e1xNW1Cyclin-dependent kinase 22.7.11.220.486
3sw719KCyclin-dependent kinase 22.7.11.220.486
2vtsLZCCyclin-dependent kinase 22.7.11.220.485
4acm7YGCyclin-dependent kinase 22.7.11.220.483
4bcnT9NCyclin-dependent kinase 22.7.11.220.483
1y91CT9Cyclin-dependent kinase 22.7.11.220.481
3lfqA28Cyclin-dependent kinase 22.7.11.220.481
3pxyJWSCyclin-dependent kinase 22.7.11.220.481
1h0vUN4Cyclin-dependent kinase 22.7.11.220.480
1h1q2A6Cyclin-dependent kinase 22.7.11.220.480
2vv9IM9Cyclin-dependent kinase 22.7.11.220.479
3qtrX36Cyclin-dependent kinase 22.7.11.220.479
4bcqTJFCyclin-dependent kinase 22.7.11.220.479
4fko20KCyclin-dependent kinase 22.7.11.220.479
1r78FMDCyclin-dependent kinase 22.7.11.220.478
1unlRRCCyclin-dependent-like kinase 52.7.11.10.478
2c6iDT1Cyclin-dependent kinase 22.7.11.220.478
4fkg4CKCyclin-dependent kinase 22.7.11.220.478
2r3iSCFCyclin-dependent kinase 22.7.11.220.477
2r3mSCXCyclin-dependent kinase 22.7.11.220.477
3fz1B98Cyclin-dependent kinase 22.7.11.220.477
1gij2PUCyclin-dependent kinase 22.7.11.220.476
1pxpCK8Cyclin-dependent kinase 22.7.11.220.476
2wxvWXVCyclin-dependent kinase 22.7.11.220.476
3le62BZCyclin-dependent kinase 22.7.11.220.476
4fkw62KCyclin-dependent kinase 22.7.11.220.476
3r8zZ63Cyclin-dependent kinase 22.7.11.220.475
3tiz3TICyclin-dependent kinase 22.7.11.220.475
4fkt48KCyclin-dependent kinase 22.7.11.220.475
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.474
2r3fSC8Cyclin-dependent kinase 22.7.11.220.474
3rzb02ZCyclin-dependent kinase 22.7.11.220.474
1oirHDYCyclin-dependent kinase 22.7.11.220.473
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.473
3r9nZ68Cyclin-dependent kinase 22.7.11.220.472
3dogNNNCyclin-dependent kinase 22.7.11.220.471
4fx360KCyclin-dependent kinase 22.7.11.220.471
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.471
2b54D05Cyclin-dependent kinase 22.7.11.220.470
2bheBRYCyclin-dependent kinase 22.7.11.220.470
2vttLZDCyclin-dependent kinase 22.7.11.220.470
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.470
4fks46KCyclin-dependent kinase 22.7.11.220.469
1h1pCMGCyclin-dependent kinase 22.7.11.220.468
3ti1B49Cyclin-dependent kinase 22.7.11.220.467
1dm2HMDCyclin-dependent kinase 22.7.11.220.466
2c6lDT4Cyclin-dependent kinase 22.7.11.220.466
3qtwX3ACyclin-dependent kinase 22.7.11.220.466
3ggfGVDSerine/threonine-protein kinase 26/0.465
2x1nX1NCyclin-dependent kinase 22.7.11.220.464
4bcoT6QCyclin-dependent kinase 22.7.11.220.464
3rmf20ZCyclin-dependent kinase 22.7.11.220.463
4eos1ROCyclin-dependent kinase 22.7.11.220.463
4fkv61KCyclin-dependent kinase 22.7.11.220.463
2wotZZGTGF-beta receptor type-12.7.11.300.462
3uli1N3Cyclin-dependent kinase 22.7.11.220.462
4eon1ROCyclin-dependent kinase 22.7.11.220.462
2uzlC94Cyclin-dependent kinase 22.7.11.220.461
4qmpDKISerine/threonine-protein kinase 242.7.11.10.460
2c6tDT5Cyclin-dependent kinase 22.7.11.220.459
2xnbY8LCyclin-dependent kinase 22.7.11.220.458
3qzfX66Cyclin-dependent kinase 22.7.11.220.458
2vthLZ2Cyclin-dependent kinase 22.7.11.220.457
3sheI85MAP kinase-activated protein kinase 32.7.11.10.456
4fv9E71Mitogen-activated protein kinase 12.7.11.240.456
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.454
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.451
1pkdUCNCyclin-dependent kinase 22.7.11.220.450
2wihP48Cyclin-dependent kinase 22.7.11.220.450
3qtsX46Cyclin-dependent kinase 22.7.11.220.449
3tnwF18Cyclin-dependent kinase 22.7.11.220.449
1v0pPVBCell division control protein 2 homolog2.7.11.220.448
2r3q5SCCyclin-dependent kinase 22.7.11.220.448
2c5nCK8Cyclin-dependent kinase 22.7.11.220.447
2r3jSCJCyclin-dependent kinase 22.7.11.220.447
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.447
3rpy27ZCyclin-dependent kinase 22.7.11.220.447
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.447
3nup3NUCyclin-dependent kinase 62.7.11.220.445
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.445
4eol1ROCyclin-dependent kinase 22.7.11.220.445
4eoi1ROCyclin-dependent kinase 22.7.11.220.444
3u4uLNHCasein kinase II subunit alpha2.7.11.10.443
1fvv107Cyclin-dependent kinase 22.7.11.220.442
1gz8MBPCyclin-dependent kinase 22.7.11.220.442
2c68CT6Cyclin-dependent kinase 22.7.11.220.442
3nwxKVSGag-Pol polyprotein3.4.23.160.442
4fv8E63Mitogen-activated protein kinase 12.7.11.240.442
2c5yMTWCyclin-dependent kinase 22.7.11.220.441
1b39ATPCyclin-dependent kinase 22.7.11.220.440
2uzdC85Cyclin-dependent kinase 22.7.11.220.440
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440