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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3qv2SAH5-cytosine DNA methyltransferase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3qv2SAH5-cytosine DNA methyltransferase/1.000
4h0nSAHDnmt2/0.512
7mhtSAHModification methylase HhaI2.1.1.370.503
5mhtSAHModification methylase HhaI2.1.1.370.502
8mhtSAHModification methylase HhaI2.1.1.370.497
9mhtSAHModification methylase HhaI2.1.1.370.497
2uyhSAHModification methylase HhaI2.1.1.370.495
1skmSAHModification methylase HhaI2.1.1.370.492
3pt6SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.491
2zcjSAHModification methylase HhaI2.1.1.370.489
4wxxSAHDNA (cytosine-5)-methyltransferase 12.1.1.370.487
1mhtSAHModification methylase HhaI2.1.1.370.468
2hmySAMModification methylase HhaI2.1.1.370.468
2z6uSAHModification methylase HhaI2.1.1.370.464
3pt9SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.458
1dhjMTXDihydrofolate reductase1.5.1.30.453
2i9kSAHModification methylase HhaI2.1.1.370.453
4da4SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.452
10mhSAHModification methylase HhaI2.1.1.370.449
3drcMTXDihydrofolate reductase1.5.1.30.448
3mhtSAHModification methylase HhaI2.1.1.370.447
4dfrMTXDihydrofolate reductase1.5.1.30.447
2c7qSAHModification methylase HhaI2.1.1.370.446
1fjxSAHModification methylase HhaI2.1.1.370.444