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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3qruX19Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3qruX19Cyclin-dependent kinase 22.7.11.221.000
3r7yZ04Cyclin-dependent kinase 22.7.11.220.648
3qwjX6ACyclin-dependent kinase 22.7.11.220.642
3sqq99ZCyclin-dependent kinase 22.7.11.220.628
3r8pZ46Cyclin-dependent kinase 22.7.11.220.624
3sw418KCyclin-dependent kinase 22.7.11.220.623
3r73X87Cyclin-dependent kinase 22.7.11.220.620
3r1sX73Cyclin-dependent kinase 22.7.11.220.617
2fvdLIACyclin-dependent kinase 22.7.11.220.616
3qrtX14Cyclin-dependent kinase 22.7.11.220.614
3r71X86Cyclin-dependent kinase 22.7.11.220.606
3rahO1ZCyclin-dependent kinase 22.7.11.220.605
3s0o50ZCyclin-dependent kinase 22.7.11.220.605
3r7uX96Cyclin-dependent kinase 22.7.11.220.604
3rpv26ZCyclin-dependent kinase 22.7.11.220.604
3r8lZ30Cyclin-dependent kinase 22.7.11.220.603
3qxoX65Cyclin-dependent kinase 22.7.11.220.594
3qqkX02Cyclin-dependent kinase 22.7.11.220.593
3r1yX76Cyclin-dependent kinase 22.7.11.220.590
3rak03ZCyclin-dependent kinase 22.7.11.220.590
3qtuX44Cyclin-dependent kinase 22.7.11.220.589
3rpo24ZCyclin-dependent kinase 22.7.11.220.589
4acm7YGCyclin-dependent kinase 22.7.11.220.588
2c6o4SPCyclin-dependent kinase 22.7.11.220.586
2w06FRVCyclin-dependent kinase 22.7.11.220.585
3rm618ZCyclin-dependent kinase 22.7.11.220.585
3qqfX07Cyclin-dependent kinase 22.7.11.220.583
3s1h56ZCyclin-dependent kinase 22.7.11.220.580
2r3mSCXCyclin-dependent kinase 22.7.11.220.579
3iggEFQCyclin-dependent kinase 22.7.11.220.578
3ral04ZCyclin-dependent kinase 22.7.11.220.577
4fkr45KCyclin-dependent kinase 22.7.11.220.577
3qtzX42Cyclin-dependent kinase 22.7.11.220.576
3qzhX69Cyclin-dependent kinase 22.7.11.220.576
3sw719KCyclin-dependent kinase 22.7.11.220.574
3r7iX9ICyclin-dependent kinase 22.7.11.220.572
2a0cCK9Cyclin-dependent kinase 22.7.11.220.571
3r9nZ68Cyclin-dependent kinase 22.7.11.220.571
1v1k3FPCyclin-dependent kinase 22.7.11.220.569
2w05FRTCyclin-dependent kinase 22.7.11.220.568
2r3p3SCCyclin-dependent kinase 22.7.11.220.566
3rmf20ZCyclin-dependent kinase 22.7.11.220.564
1w0xOLOCyclin-dependent kinase 22.7.11.220.562
2b55D31Cyclin-dependent kinase 22.7.11.220.562
3rk909ZCyclin-dependent kinase 22.7.11.220.562
1p2a5BNCyclin-dependent kinase 22.7.11.220.561
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.561
3qqlX03Cyclin-dependent kinase 22.7.11.220.561
1h0w207Cyclin-dependent kinase 22.7.11.220.560
3rkb12ZCyclin-dependent kinase 22.7.11.220.560
3r7vZ02Cyclin-dependent kinase 22.7.11.220.559
2r3kSCQCyclin-dependent kinase 22.7.11.220.558
3qu0X40Cyclin-dependent kinase 22.7.11.220.558
2vu3LZECyclin-dependent kinase 22.7.11.220.557
4fko20KCyclin-dependent kinase 22.7.11.220.557
4kd11QKCyclin-dependent kinase 22.7.11.220.557
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.556
3lfnA27Cyclin-dependent kinase 22.7.11.220.556
3qtxX43Cyclin-dependent kinase 22.7.11.220.555
3rk507ZCyclin-dependent kinase 22.7.11.220.555
1urwI1PCyclin-dependent kinase 22.7.11.220.554
3rni21ZCyclin-dependent kinase 22.7.11.220.554
1ke6LS2Cyclin-dependent kinase 22.7.11.220.553
2b52D42Cyclin-dependent kinase 22.7.11.220.553
1pxmCK5Cyclin-dependent kinase 22.7.11.220.551
2vv9IM9Cyclin-dependent kinase 22.7.11.220.547
3ezrEZRCyclin-dependent kinase 22.7.11.220.546
1w8cN69Cyclin-dependent kinase 22.7.11.220.545
3roy22ZCyclin-dependent kinase 22.7.11.220.545
4bgh3I6Cyclin-dependent kinase 22.7.11.220.545
3r28XA0Cyclin-dependent kinase 22.7.11.220.544
3r8vZ62Cyclin-dependent kinase 22.7.11.220.544
3qwkX62Cyclin-dependent kinase 22.7.11.220.543
3unj0BXCyclin-dependent kinase 22.7.11.220.543
1h1r6CPCyclin-dependent kinase 22.7.11.220.542
3r1qX75Cyclin-dependent kinase 22.7.11.220.542
3rjc06ZCyclin-dependent kinase 22.7.11.220.542
3rm719ZCyclin-dependent kinase 22.7.11.220.542
1ke7LS3Cyclin-dependent kinase 22.7.11.220.541
3qx2X63Cyclin-dependent kinase 22.7.11.220.541
4fkq42KCyclin-dependent kinase 22.7.11.220.541
3qxpX64Cyclin-dependent kinase 22.7.11.220.540
3ig7EFPCyclin-dependent kinase 22.7.11.220.539
2w1hL0FCyclin-dependent kinase 22.7.11.220.538
3rk708ZCyclin-dependent kinase 22.7.11.220.537
3qtrX36Cyclin-dependent kinase 22.7.11.220.536
3r83Z14Cyclin-dependent kinase 22.7.11.220.536
3qx4X4BCyclin-dependent kinase 22.7.11.220.535
3unk0BYCyclin-dependent kinase 22.7.11.220.535
4ek816KCyclin-dependent kinase 22.7.11.220.535
1oirHDYCyclin-dependent kinase 22.7.11.220.534
4fkpLS5Cyclin-dependent kinase 22.7.11.220.534
1pxpCK8Cyclin-dependent kinase 22.7.11.220.533
2r3lSCWCyclin-dependent kinase 22.7.11.220.533
2r3r6SCCyclin-dependent kinase 22.7.11.220.532
2r64740Cyclin-dependent kinase 22.7.11.220.532
3r6xX84Cyclin-dependent kinase 22.7.11.220.532
3r9dX6BCyclin-dependent kinase 22.7.11.220.532
3qzgX67Cyclin-dependent kinase 22.7.11.220.531
2c6mDT5Cyclin-dependent kinase 22.7.11.220.530
3r7eX88Cyclin-dependent kinase 22.7.11.220.530
1oiyN41Cyclin-dependent kinase 22.7.11.220.529
2duv371Cyclin-dependent kinase 22.7.11.220.529
3dogNNNCyclin-dependent kinase 22.7.11.220.529
1h1s4SPCyclin-dependent kinase 22.7.11.220.527
1oitHDTCyclin-dependent kinase 22.7.11.220.525
3pj8404Cyclin-dependent kinase 22.7.11.220.525
2uzoC62Cyclin-dependent kinase 22.7.11.220.524
3r9hZ67Cyclin-dependent kinase 22.7.11.220.524
4lyn1YGCyclin-dependent kinase 22.7.11.220.524
1g5sI17Cyclin-dependent kinase 22.7.11.220.522
3s2pPMUCyclin-dependent kinase 22.7.11.220.521
4fkw62KCyclin-dependent kinase 22.7.11.220.520
1ke5LS1Cyclin-dependent kinase 22.7.11.220.519
2bheBRYCyclin-dependent kinase 22.7.11.220.519
2iw84SPCyclin-dependent kinase 22.7.11.220.518
3qziX72Cyclin-dependent kinase 22.7.11.220.518
1oiqHDUCyclin-dependent kinase 22.7.11.220.516
2btsU32Cyclin-dependent kinase 22.7.11.220.516
1oguST8Cyclin-dependent kinase 22.7.11.220.515
2r3fSC8Cyclin-dependent kinase 22.7.11.220.514
3lfsA07Cyclin-dependent kinase 22.7.11.220.514
4fks46KCyclin-dependent kinase 22.7.11.220.514
3rpr25ZCyclin-dependent kinase 22.7.11.220.513
4fx360KCyclin-dependent kinase 22.7.11.220.513
1pxkCK3Cyclin-dependent kinase 22.7.11.220.512
2vttLZDCyclin-dependent kinase 22.7.11.220.512
3raiX85Cyclin-dependent kinase 22.7.11.220.512
3ql8X01Cyclin-dependent kinase 22.7.11.220.511
1di8DTQCyclin-dependent kinase 22.7.11.220.510
1fvt106Cyclin-dependent kinase 22.7.11.220.509
1ykr628Cyclin-dependent kinase 22.7.11.220.509
4erwSTUCyclin-dependent kinase 22.7.11.220.509
3r8uZ31Cyclin-dependent kinase 22.7.11.220.508
4eor4SPCyclin-dependent kinase 22.7.11.220.508
1oi9N20Cyclin-dependent kinase 22.7.11.220.507
2btrU73Cyclin-dependent kinase 22.7.11.220.507
2c6iDT1Cyclin-dependent kinase 22.7.11.220.507
3ddpRC8Cyclin-dependent kinase 22.7.11.220.507
1gih1PUCyclin-dependent kinase 22.7.11.220.505
1gii1PUCyclin-dependent kinase 22.7.11.220.505
3ezvEZVCyclin-dependent kinase 22.7.11.220.505
3r8zZ63Cyclin-dependent kinase 22.7.11.220.505
1ke9LS5Cyclin-dependent kinase 22.7.11.220.504
2a4lRRCCyclin-dependent kinase 22.7.11.220.504
2r3iSCFCyclin-dependent kinase 22.7.11.220.504
4eol1ROCyclin-dependent kinase 22.7.11.220.504
4fki09KCyclin-dependent kinase 22.7.11.220.504
1vyzN5BCyclin-dependent kinase 22.7.11.220.503
1ke8LS4Cyclin-dependent kinase 22.7.11.220.502
3ddqRRCCyclin-dependent kinase 22.7.11.220.502
3pxyJWSCyclin-dependent kinase 22.7.11.220.501
3qtsX46Cyclin-dependent kinase 22.7.11.220.501
1h1pCMGCyclin-dependent kinase 22.7.11.220.500
1vyw292Cyclin-dependent kinase 22.7.11.220.500
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.500
1gz8MBPCyclin-dependent kinase 22.7.11.220.499
4bcmT7ZCyclin-dependent kinase 22.7.11.220.499
3s00Z60Cyclin-dependent kinase 22.7.11.220.498
1ckpPVBCyclin-dependent kinase 22.7.11.220.497
3rpy27ZCyclin-dependent kinase 22.7.11.220.497
4fkv61KCyclin-dependent kinase 22.7.11.220.497
4qmpDKISerine/threonine-protein kinase 242.7.11.10.496
1y91CT9Cyclin-dependent kinase 22.7.11.220.495
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.495
3u4uLNHCasein kinase II subunit alpha2.7.11.10.495
2xmyCDKCyclin-dependent kinase 22.7.11.220.494
3at4CCKCasein kinase II subunit alpha2.7.11.10.494
2wxvWXVCyclin-dependent kinase 22.7.11.220.493
3tiz3TICyclin-dependent kinase 22.7.11.220.493
1pkdUCNCyclin-dependent kinase 22.7.11.220.492
3fz1B98Cyclin-dependent kinase 22.7.11.220.492
2i40BLZCyclin-dependent kinase 22.7.11.220.490
1fvv107Cyclin-dependent kinase 22.7.11.220.489
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.489
2wpa889Cyclin-dependent kinase 22.7.11.220.489
4ez30S0Cyclin-dependent kinase 22.7.11.220.489
1oiuN76Cyclin-dependent kinase 22.7.11.220.486
2wihP48Cyclin-dependent kinase 22.7.11.220.486
3lfqA28Cyclin-dependent kinase 22.7.11.220.486
3qqhX0ACyclin-dependent kinase 22.7.11.220.486
3qzfX66Cyclin-dependent kinase 22.7.11.220.486
1unlRRCCyclin-dependent-like kinase 52.7.11.10.485
2x1nX1NCyclin-dependent kinase 22.7.11.220.485
2zjwREFCasein kinase II subunit alpha2.7.11.10.485
3ti1B49Cyclin-dependent kinase 22.7.11.220.485
3py0SU9Cyclin-dependent kinase 22.7.11.220.484
2c68CT6Cyclin-dependent kinase 22.7.11.220.483
4ez50RSCyclin-dependent kinase 62.7.11.220.483
2r3o2SCCyclin-dependent kinase 22.7.11.220.482
2r3q5SCCyclin-dependent kinase 22.7.11.220.482
4bcnT9NCyclin-dependent kinase 22.7.11.220.482
1e1xNW1Cyclin-dependent kinase 22.7.11.220.481
2c69CT8Cyclin-dependent kinase 22.7.11.220.481
2vtsLZCCyclin-dependent kinase 22.7.11.220.481
3qtqX35Cyclin-dependent kinase 22.7.11.220.481
1gij2PUCyclin-dependent kinase 22.7.11.220.480
2r3jSCJCyclin-dependent kinase 22.7.11.220.480
2xnbY8LCyclin-dependent kinase 22.7.11.220.479
1e9hINRCyclin-dependent kinase 22.7.11.220.477
3ggfGVDSerine/threonine-protein kinase 26/0.477
3my5RFZCyclin-dependent kinase 22.7.11.220.477
4eok4SPCyclin-dependent kinase 22.7.11.220.477
2iw94SPCyclin-dependent kinase 22.7.11.220.476
1aq1STUCyclin-dependent kinase 22.7.11.220.475
2c4g514Cyclin-dependent kinase 22.7.11.220.475
2uzbC75Cyclin-dependent kinase 22.7.11.220.475
4eos1ROCyclin-dependent kinase 22.7.11.220.475
4fkj11KCyclin-dependent kinase 22.7.11.220.475
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.473
3qtwX3ACyclin-dependent kinase 22.7.11.220.473
2r3gSC9Cyclin-dependent kinase 22.7.11.220.472
3le62BZCyclin-dependent kinase 22.7.11.220.471
4cfnJYMCyclin-dependent kinase 22.7.11.220.471
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.471
3sheI85MAP kinase-activated protein kinase 32.7.11.10.470
4bcpT3CCyclin-dependent kinase 22.7.11.220.469
4gub0Y4Casein kinase II subunit alpha2.7.11.10.469
4bcqTJFCyclin-dependent kinase 22.7.11.220.468
4eon1ROCyclin-dependent kinase 22.7.11.220.468
1pxlCK4Cyclin-dependent kinase 22.7.11.220.467
1pyePM1Cyclin-dependent kinase 22.7.11.220.467
1xjdSTUProtein kinase C theta type2.7.11.130.466
2uznC96Cyclin-dependent kinase 22.7.11.220.466
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.466
2c6kDT2Cyclin-dependent kinase 22.7.11.220.465
3pe2E1BCasein kinase II subunit alpha2.7.11.10.465
3wblPDYCyclin-dependent kinase 22.7.11.220.465
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.463
3be9P04Casein kinase II subunit alpha2.7.11.10.462
3nga3NGCasein kinase II subunit alpha2.7.11.10.462
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.460
1r78FMDCyclin-dependent kinase 22.7.11.220.460
2c5nCK8Cyclin-dependent kinase 22.7.11.220.460
2vtqLZACyclin-dependent kinase 22.7.11.220.460
2w17I19Cyclin-dependent kinase 22.7.11.220.460
4bcoT6QCyclin-dependent kinase 22.7.11.220.460
1h1q2A6Cyclin-dependent kinase 22.7.11.220.459
2exmZIPCyclin-dependent kinase 22.7.11.220.458
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
4eoi1ROCyclin-dependent kinase 22.7.11.220.458
3mtfA3FActivin receptor type-12.7.11.300.457
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.456
1y8yCT7Cyclin-dependent kinase 22.7.11.220.456
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.456
3eb0DRKUncharacterized protein/0.456
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.456
2pvlP55Casein kinase II subunit alpha2.7.11.10.455
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.455
3uli1N3Cyclin-dependent kinase 22.7.11.220.455
1pxoCK7Cyclin-dependent kinase 22.7.11.220.454
2b53D23Cyclin-dependent kinase 22.7.11.220.454
2cchATPCyclin-dependent kinase 22.7.11.220.453
2pvnP63Casein kinase II subunit alpha2.7.11.10.453
3gggNADPrephenate dehydrogenase/0.453
3wowANPCasein kinase II subunit alpha2.7.11.10.453
4ek610KCyclin-dependent kinase 22.7.11.220.453
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.453
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.452
4dgnLU2Casein kinase II subunit alpha2.7.11.10.452
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.452
2c5yMTWCyclin-dependent kinase 22.7.11.220.451
2uzdC85Cyclin-dependent kinase 22.7.11.220.451
2wotZZGTGF-beta receptor type-12.7.11.300.451
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.451
5dr6SKEAurora kinase A2.7.11.10.451
2bhhRYUCyclin-dependent kinase 22.7.11.220.450
3at3ATKCasein kinase II subunit alpha2.7.11.10.450
4hgt15GCasein kinase I isoform delta2.7.11.10.450
1xl2189Gag-Pol polyprotein3.4.23.160.449
2c6lDT4Cyclin-dependent kinase 22.7.11.220.449
4eop1ROCyclin-dependent kinase 22.7.11.220.449
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.449
4gmy0X5Tyrosine-protein kinase JAK2/0.449
5cu6ATPCasein kinase II subunit alpha2.7.11.10.449
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.448
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.448
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.448
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.447
4g1wG1WMitogen-activated protein kinase 82.7.11.240.447
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.447
1h0vUN4Cyclin-dependent kinase 22.7.11.220.446
1v0pPVBCell division control protein 2 homolog2.7.11.220.446
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.446
2uzlC94Cyclin-dependent kinase 22.7.11.220.446
2wipP49Cyclin-dependent kinase 22.7.11.220.446
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.446
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.445
2pmnK51Protein kinase 7/0.445
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.445
2xa4AZ5Tyrosine-protein kinase JAK2/0.445
3a60STURibosomal protein S6 kinase beta-12.7.11.10.445
4aguD15Cyclin-dependent kinase-like 1/0.445
5cshATPCasein kinase II subunit alpha2.7.11.10.445
3axwTIDCasein kinase II subunit alpha2.7.11.10.444
3so9017Pol protein/0.444
4fv9E71Mitogen-activated protein kinase 12.7.11.240.444
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.443
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.443
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.443
4ivb1J5Tyrosine-protein kinase JAK1/0.443
2uzeC95Cyclin-dependent kinase 22.7.11.220.442
4jq8KJ8Epidermal growth factor receptor2.7.10.10.442
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.442
2j9mPY8Cyclin-dependent kinase 22.7.11.220.441
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.441
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.441
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.441
4i22IREEpidermal growth factor receptor2.7.10.10.441
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.441
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
2fde385Gag-Pol polyprotein3.4.23.160.440
3el01UNGag-Pol polyprotein3.4.23.160.440
3el4ROCGag-Pol polyprotein3.4.23.160.440
3gxlQIGTGF-beta receptor type-12.7.11.300.440
3hx4ANPCalmodulin-domain protein kinase 1/0.440
3nduROCGag-Pol polyprotein3.4.23.160.440
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.440
3sa4F72Protease/0.440
3upjU03Gag-Pol polyprotein/0.440
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.440