sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.639 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.635 | |
| 3qly | 55V | Uncharacterized protein | / | 0.616 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.615 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.605 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.604 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.603 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.603 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.598 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.597 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.596 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.590 | |
| 3eek | 53S | Uncharacterized protein | / | 0.585 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.583 | |
| 3cse | N22 | Uncharacterized protein | / | 0.582 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.576 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.570 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.565 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.565 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.564 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.559 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.555 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.554 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.551 | |
| 3eem | 53V | Uncharacterized protein | / | 0.550 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.550 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.550 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.548 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.545 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.545 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.544 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.543 | |
| 3eej | 53R | Uncharacterized protein | / | 0.543 | |
| 3eel | 53T | Uncharacterized protein | / | 0.543 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.539 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.537 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.536 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.533 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.532 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.531 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.530 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.529 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.529 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.528 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.524 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.519 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.519 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.518 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.518 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.518 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.516 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.513 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.513 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.510 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.510 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.507 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.506 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.503 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.502 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.501 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.500 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.498 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.497 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.496 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.494 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.492 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.491 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.490 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.489 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.486 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.483 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.481 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.481 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.480 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.479 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.478 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.475 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.474 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 3lu8 | IQX | Serum albumin | / | 0.474 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.473 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.473 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.470 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.468 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.464 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.463 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.463 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.461 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.461 | |
| 4p68 | MTX | Dihydrofolate reductase | / | 0.461 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.461 | |
| 2d0k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 4fhb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.459 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1kij | NOV | DNA gyrase subunit B | / | 0.458 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.458 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.457 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.457 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.456 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.455 | |
| 3ezp | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.455 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.455 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.455 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.454 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.453 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.453 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4imw | 1EV | Nitric oxide synthase, brain | 1.14.13.39 | 0.453 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.452 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.451 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.451 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.450 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.450 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.449 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.449 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.449 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.448 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.448 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.448 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.448 | |
| 3bej | MUF | Bile acid receptor | / | 0.447 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.447 | |
| 3rg9 | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.447 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.447 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.446 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.446 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.446 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.446 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.446 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.445 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.444 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.444 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.444 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.444 | |
| 4lux | QJ8 | Nitric oxide synthase, brain | 1.14.13.39 | 0.444 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.444 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.443 | |
| 4v12 | POG | MaoC like domain protein | / | 0.443 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.442 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.441 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.441 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.441 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3nlq | JRR | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.441 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.440 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.440 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.440 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.440 |