sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.651 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.644 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.622 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.615 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.611 | |
| 3qly | 55V | Uncharacterized protein | / | 0.608 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.605 | |
| 3eek | 53S | Uncharacterized protein | / | 0.602 | |
| 3cse | N22 | Uncharacterized protein | / | 0.598 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.598 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.598 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.594 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.592 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.584 | |
| 3eem | 53V | Uncharacterized protein | / | 0.582 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.579 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.576 | |
| 3eej | 53R | Uncharacterized protein | / | 0.575 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.574 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.571 | |
| 3eel | 53T | Uncharacterized protein | / | 0.569 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.568 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.563 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.559 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.558 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.557 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.556 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.554 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.549 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.548 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.547 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.547 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.547 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.547 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.546 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.545 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.545 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.545 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.542 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.539 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.528 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.527 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.527 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.526 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.526 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.523 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.518 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.518 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.518 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.517 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.516 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.512 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.509 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.506 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.504 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.504 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.504 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.501 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.500 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.498 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.497 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.495 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.492 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.491 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.490 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.490 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.489 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.489 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.488 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.487 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.485 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.482 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.481 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.479 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.478 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.477 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.477 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.476 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.476 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.474 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.470 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.470 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.470 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.470 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.469 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.468 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.467 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.467 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.465 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.464 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.464 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.463 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.462 | |
| 3sqy | Q11 | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.462 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.461 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.460 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.460 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.460 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.460 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.460 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.458 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.458 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.457 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.457 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.455 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4m7v | RAR | Dihydrofolate reductase | / | 0.454 | |
| 4zas | TYD | CalS13 | / | 0.454 | |
| 1d2s | DHT | Sex hormone-binding globulin | / | 0.453 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.452 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.452 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.452 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.451 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.451 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.451 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1pp9 | SMA | Cytochrome b | / | 0.450 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.450 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.450 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.450 | |
| 4p68 | MTX | Dihydrofolate reductase | / | 0.450 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.449 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.449 | |
| 4iv2 | 1GR | Estrogen receptor | / | 0.449 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.448 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 1dyr | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3mg3 | ECH | Orange carotenoid-binding protein | / | 0.447 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4kfp | 1R7 | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.447 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.446 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.446 | |
| 1rx2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.446 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.446 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.446 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.446 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.446 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 4l9q | 9TP | Serum albumin | / | 0.445 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.445 | |
| 2jfa | RAL | Estrogen receptor | / | 0.444 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.444 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.444 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.443 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.443 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.442 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.442 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.442 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.442 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.442 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.442 | |
| 4jnm | 1LJ | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.442 | |
| 4o28 | 1QS | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.442 | |
| 1kij | NOV | DNA gyrase subunit B | / | 0.441 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1rx6 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.441 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.440 |