sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 1.000 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.719 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.663 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.622 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.602 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.595 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.594 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.592 | |
| 3qly | 55V | Uncharacterized protein | / | 0.581 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.579 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.575 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.573 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.573 | |
| 3cse | N22 | Uncharacterized protein | / | 0.572 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.572 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.571 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.570 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.568 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.567 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.567 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.560 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.559 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.559 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.557 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.556 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.555 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.554 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.554 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.549 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.549 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.549 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.548 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.547 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.547 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.547 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.546 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.545 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.542 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.539 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.539 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.539 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.539 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.538 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.536 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.536 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.535 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.529 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.528 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.527 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.526 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.526 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.525 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.524 | |
| 3eem | 53V | Uncharacterized protein | / | 0.524 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.524 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.524 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.523 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.519 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.518 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.516 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 3eek | 53S | Uncharacterized protein | / | 0.515 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.514 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 3rg9 | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.511 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.508 | |
| 3eej | 53R | Uncharacterized protein | / | 0.508 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.502 | |
| 1dre | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.500 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.499 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.495 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.495 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.495 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.495 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.494 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 4p68 | MTX | Dihydrofolate reductase | / | 0.494 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.493 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.492 | |
| 3sqy | Q11 | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 4fhb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.490 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.490 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.490 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.487 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.486 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.485 | |
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.485 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.483 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.482 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.482 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.482 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.482 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.481 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.480 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.480 | |
| 1rh3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.479 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.479 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.478 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.477 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.476 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.476 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.475 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.475 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.475 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.475 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 2q7g | CCL | Pyrrolysine--tRNA ligase | / | 0.474 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.474 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.474 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.473 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.472 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1ra2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.471 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.470 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.470 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.470 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.470 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.469 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.469 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.468 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.468 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.468 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.468 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.468 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.467 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.467 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 3eel | 53T | Uncharacterized protein | / | 0.467 | |
| 3l03 | 4OH | Estrogen receptor | / | 0.467 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.467 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.467 | |
| 4x5h | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.466 | |
| 4lc7 | 1WP | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 4v12 | POG | MaoC like domain protein | / | 0.466 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.465 | |
| 1osv | CHC | Bile acid receptor | / | 0.465 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.465 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.465 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.465 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.465 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.465 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 1nbm | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.464 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1xp9 | AIJ | Estrogen receptor | / | 0.464 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.464 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3lnb | COA | N-acetyltransferase family protein | / | 0.463 | |
| 3qyo | Q24 | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.462 | |
| 2ejz | SAH | Diphthine synthase | / | 0.462 | |
| 3bgr | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.462 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.462 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.462 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.461 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 2p15 | EZT | Estrogen receptor | / | 0.461 | |
| 2vte | IK4 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.461 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.461 | |
| 1dyr | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 1zky | 689 | Estrogen receptor | / | 0.460 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.460 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.460 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.460 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.460 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.460 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.460 | |
| 1e1n | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.459 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2ibz | UQ6 | Cytochrome b | / | 0.458 | |
| 2q70 | DC8 | Estrogen receptor | / | 0.458 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.458 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.457 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.457 | |
| 2rab | NAD | Glutathione amide reductase | / | 0.457 | |
| 3kp4 | MII | Transcriptional regulator TcaR | / | 0.457 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.457 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 1gwr | EST | Estrogen receptor | / | 0.456 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.456 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.456 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.456 | |
| 4m7v | RAR | Dihydrofolate reductase | / | 0.456 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.456 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.455 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.455 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4rbs | 0RV | Metallo-beta-lactamase type 2 | / | 0.455 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.454 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.454 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.454 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.454 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.454 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.454 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.453 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.453 | |
| 3q95 | ESL | Estrogen receptor | / | 0.453 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.453 | |
| 4jnc | 1LF | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.453 | |
| 4qjc | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1d2s | DHT | Sex hormone-binding globulin | / | 0.452 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.452 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.452 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.452 | |
| 2zce | PYL | Pyrrolysine--tRNA ligase | / | 0.452 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.452 | |
| 3el8 | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.452 | |
| 3uud | EST | Estrogen receptor | / | 0.452 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.452 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.452 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.452 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 4lwa | Q13 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.452 | |
| 1pl6 | 572 | Sorbitol dehydrogenase | 1.1.1.14 | 0.451 | |
| 1rx2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1sqi | 869 | 4-hydroxyphenylpyruvate dioxygenase | / | 0.451 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.451 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.451 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.451 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 4l8u | 9AZ | Serum albumin | / | 0.451 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.450 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.450 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.450 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.450 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.450 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.450 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.450 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.450 | |
| 1jra | FAD | FAD-linked sulfhydryl oxidase ERV2 | 1.8.3.2 | 0.449 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.449 | |
| 1rg7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.449 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.449 | |
| 1c1b | GCA | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.448 | |
| 1k27 | MTM | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 4j4v | SVR | Nucleocapsid protein | / | 0.448 | |
| 5dp2 | NAP | CurF | / | 0.448 | |
| 5iw5 | NMN | NADH pyrophosphatase | / | 0.448 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1dtp | APU | Diphtheria toxin | / | 0.447 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.447 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.447 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.447 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.447 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.447 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.447 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 3pre | 3RE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.447 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.446 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.446 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.446 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.446 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.446 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.446 | |
| 3wsb | RWZ | Farnesyltransferase, putative | / | 0.446 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.446 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.446 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.446 | |
| 1mew | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.445 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2b1z | 17M | Estrogen receptor | / | 0.445 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.445 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.445 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.445 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.445 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.445 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.445 | |
| 4j26 | EST | Estrogen receptor beta | / | 0.445 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1fml | RTL | Retinol dehydratase | / | 0.444 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.444 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.444 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.444 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.444 | |
| 1dlj | UGA | UDP-glucose 6-dehydrogenase | / | 0.443 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 1psd | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.443 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.443 | |
| 3nmv | PYV | Abscisic acid receptor PYL2 | / | 0.443 | |
| 3oll | EST | Estrogen receptor beta | / | 0.443 | |
| 4b6u | M7G | Eukaryotic translation initiation factor 4E type 3 | / | 0.443 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.443 | |
| 4lt6 | 3AT | Poly(A) polymerase gamma | 2.7.7.19 | 0.443 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.443 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.442 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 1x7e | 244 | Estrogen receptor | / | 0.442 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 3ant | S82 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.442 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.442 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.442 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.442 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 3up0 | D7S | aceDAF-12 | / | 0.442 | |
| 4czt | CPS | CBL-interacting serine/threonine-protein kinase 23 | 2.7.11.1 | 0.442 | |
| 4jf1 | PLP | Acetylornithine/succinyldiaminopimelate aminotransferase | 2.6.1.11 | 0.442 | |
| 4l9q | 9TP | Serum albumin | / | 0.442 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.442 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.442 | |
| 1ddu | CB3 | Thymidylate synthase | / | 0.441 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.441 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.441 | |
| 1rv1 | IMZ | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.441 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.441 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.441 | |
| 1xp6 | AIU | Estrogen receptor | / | 0.441 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 2pog | WST | Estrogen receptor | / | 0.441 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.441 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 4az3 | S35 | Lysosomal protective protein | 3.4.16.5 | 0.441 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.441 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.441 | |
| 1ddu | DDU | Thymidylate synthase | / | 0.440 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.440 | |
| 1rx6 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.440 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.440 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.440 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.440 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.440 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4kln | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.440 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.440 |