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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3qfsFADNADPH--cytochrome P450 reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3qfsFADNADPH--cytochrome P450 reductase/1.000
1ja1FADNADPH--cytochrome P450 reductase/0.645
4y7cFADNADPH--cytochrome P450 reductase/0.634
4y9uFADNADPH--cytochrome P450 reductase/0.625
1amoFADNADPH--cytochrome P450 reductase/0.614
3qe2FADNADPH--cytochrome P450 reductase/0.608
3w5uFADFerredoxin/0.602
3qfcFADNADPH--cytochrome P450 reductase/0.601
4yafFADNADPH--cytochrome P450 reductase/0.591
3ojxFADNADPH--cytochrome P450 reductase/0.588
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.587
3qftFADNADPH--cytochrome P450 reductase/0.581
1j9zFADNADPH--cytochrome P450 reductase/0.575
1f20FADNitric oxide synthase, brain1.14.13.390.574
1gjrFADFerredoxin--NADP reductase1.18.1.20.574
1tllFADNitric oxide synthase, brain1.14.13.390.571
1w35FADFerredoxin--NADP reductase1.18.1.20.569
4yaoFADNADPH--cytochrome P450 reductase/0.569
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.565
4y9rFADNADPH--cytochrome P450 reductase/0.565
4c43FADFerredoxin--NADP reductase1.18.1.20.563
1qgyFADFerredoxin--NADP reductase1.18.1.20.552
1e64FADFerredoxin--NADP reductase1.18.1.20.547
2bpoFADNADPH--cytochrome P450 reductase/0.547
3fpkFADFerredoxin-NADP reductase/0.546
1bjkFADFerredoxin--NADP reductase1.18.1.20.541
1fncFDAFerredoxin--NADP reductase, chloroplastic1.18.1.20.541
3zbtFADFerredoxin--NADP reductase1.18.1.20.541
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.535
3zc3FADFerredoxin--NADP reductase1.18.1.20.534
1gaqFADFerredoxin/0.533
1qh0FADFerredoxin--NADP reductase1.18.1.20.533
4yauFADNADPH--cytochrome P450 reductase/0.533
2rc5FADFerredoxin--NADP reductase/0.532
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.532
2bf4FADNADPH--cytochrome P450 reductase/0.529
1gawFADFerredoxin/0.528
2rc6FADFerredoxin--NADP reductase/0.528
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.527
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.526
1w87FADFerredoxin--NADP reductase1.18.1.20.525
1h85FADFerredoxin--NADP reductase1.18.1.20.522
1go2FADFerredoxin--NADP reductase1.18.1.20.519
2b5oFADFerredoxin--NADP reductase1.18.1.20.517
2piaFMNPhthalate dioxygenase reductase/0.517
3vo2FADFerredoxin--NADP reductase/0.510
1sm4FADFerredoxin--NADP reductase/0.509
4fk8FADFerredoxin--NADP reductase/0.509
1ewyFADFerredoxin--NADP reductase1.18.1.20.508
1b2rFADFerredoxin--NADP reductase1.18.1.20.503
1ja0FADNADPH--cytochrome P450 reductase/0.502
1gvhFADFlavohemoprotein/0.493
1queFADFerredoxin--NADP reductase1.18.1.20.492
2xncFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.492
1fdrFADFerredoxin--NADP reductase1.18.1.20.490
4bprFADFerredoxin--NADP reductase1.18.1.20.489
2vnjFADNADPH:ferredoxin reductase/0.488
1cqxFADFlavohemoprotein/0.484
1e63FADFerredoxin--NADP reductase1.18.1.20.484
1fndFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.483
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.483
1a8pFADFerredoxin--NADP reductase/0.481
1h42FADFerredoxin--NADP reductase1.18.1.20.481
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.481
2bgiFADNADPH:ferredoxin reductase/0.477
1e62FADFerredoxin--NADP reductase1.18.1.20.473
1xddAAYIntegrin alpha-L/0.473
2ed3SAHDiphthine synthase/0.473
1cnfFADNitrate reductase [NADH]1.7.1.10.471
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.466
1umkFADNADH-cytochrome b5 reductase 31.6.2.20.466
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.466
1krhFADBenzoate 1,2-dioxygenase electron transfer component1.18.1.30.464
4k1xFADNADPH:ferredoxin reductase/0.464
3fhxPXLPyridoxal kinase2.7.1.350.462
4bfvZVVPantothenate kinase2.7.1.330.461
1yqzCOACoenzyme A disulfide reductase/0.460
2vnkFADNADPH:ferredoxin reductase/0.460
2bgjFADNADPH:ferredoxin reductase/0.456
2qimZEAClass 10 plant pathogenesis-related protein/0.456
4fse0VABeta-secretase 13.4.23.460.456
1gr1FADFerredoxin--NADP reductase1.18.1.20.455
4du82P0Mevalonate diphosphate decarboxylase/0.455
1icpFMN12-oxophytodienoate reductase 11.3.1.420.454
1qgzFADFerredoxin--NADP reductase1.18.1.20.454
2vnhFADNADPH:ferredoxin reductase/0.454
4u8iFDAUDP-galactopyranose mutase/0.454
2owfSAHDiphthine synthase/0.453
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.453
4eqsCOACoenzyme A disulfide reductase/0.453
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.452
4bftZVTPantothenate kinase2.7.1.330.452
4bfxZVXPantothenate kinase2.7.1.330.451
4jlm1NNDeoxycytidine kinase2.7.1.740.451
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.450
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.449
3hl0NADMaleylacetate reductase/0.449
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.447
3ojwFADNADPH--cytochrome P450 reductase/0.447
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.447
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
5dozNDPJamJ/0.446
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.445
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.445
2p6kSAHDiphthine synthase/0.445
3ha7B32Hydroxymycolate synthase MmaA42.1.10.445
4kc4WS3Histo-blood group ABO system transferase/0.445
1x1aSAMC-20 methyltransferase/0.444
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3h3r14HCollagen type IV alpha-3-binding protein/0.444
2ek4SAHDiphthine synthase/0.443
2ok8FADFerredoxin--NADP reductase, apicoplast/0.443
3b1dPLSBetaC-S lyase/0.443
4obwSAM2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial/0.443
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1sq5ADPPantothenate kinase2.7.1.330.442
2ejzSAHDiphthine synthase/0.442
3gwfFADCyclohexanone monooxygenase/0.441
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.441
1xe55FEPlasmepsin-23.4.23.390.440
1xe65FPPlasmepsin-23.4.23.390.440
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
2ejkSAHDiphthine synthase/0.440