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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.91.000
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.607
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.606
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.583
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.546
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.545
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.522
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.521
1gerFADGlutathione reductase1.8.1.70.518
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.513
2v6oFADThioredoxin glutathione reductase/0.508
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.507
1febFADTrypanothione reductase1.8.1.120.504
1greFADGlutathione reductase, mitochondrial1.8.1.70.504
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.503
2r9zFADGlutathione amide reductase/0.500
1grgFADGlutathione reductase, mitochondrial1.8.1.70.498
1grhFADGlutathione reductase, mitochondrial1.8.1.70.496
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.496
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.493
3grsFADGlutathione reductase, mitochondrial1.8.1.70.493
1graFADGlutathione reductase, mitochondrial1.8.1.70.489
4j56FADThioredoxin reductase 21.8.1.90.483
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.475
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.472
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.471
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.468
1feaFADTrypanothione reductase1.8.1.120.456
2zzcFADThioredoxin reductase 1, cytoplasmic1.8.1.90.454
3ic9FADPutative dihydrolipoamide dehydrogenase/0.452
1geuFADGlutathione reductase1.8.1.70.451
2rabFADGlutathione amide reductase/0.450
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.450
4jq9FADDihydrolipoyl dehydrogenase/0.447
1zk7FADMercuric reductase1.16.1.10.444
1zx9FADMercuric reductase1.16.1.10.442