sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3qci | NX3 | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3qci | NX3 | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 1.000 | |
| 3qcl | NXV | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 0.653 | |
| 3qch | NX2 | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 0.646 | |
| 3qck | NX5 | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 0.641 | |
| 3qcm | NXW | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 0.550 | |
| 3qcf | NXY | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 0.528 | |
| 3qce | NXY | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 0.527 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.523 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.504 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.498 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.494 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.492 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.492 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.490 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.490 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.486 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.483 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.481 | |
| 3meg | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.481 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.480 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.480 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.477 | |
| 5dq8 | FLF | Transcriptional enhancer factor TEF-4 | / | 0.477 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 3e01 | PZ2 | Gag-Pol polyprotein | 2.7.7.49 | 0.476 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.476 | |
| 3qcj | NX4 | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 0.476 | |
| 3glm | COO | Glutaconyl-CoA decarboxylase alpha subunit | / | 0.475 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.474 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.473 | |
| 4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.472 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.470 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.470 | |
| 1fvp | FMA | Non-fluorescent flavoprotein | / | 0.469 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 2uzt | SS3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.469 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.469 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.469 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.469 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.469 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.469 | |
| 4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.469 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.469 | |
| 1j7u | ANP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.468 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.468 | |
| 3g0f | B49 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.468 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.468 | |
| 4bb4 | 32W | Ephrin type-B receptor 4 | 2.7.10.1 | 0.468 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.468 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.468 | |
| 3qly | 55V | Uncharacterized protein | / | 0.467 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.466 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.466 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.466 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.466 | |
| 2wet | FAD | Tryptophan 5-halogenase | / | 0.466 | |
| 3i28 | 34N | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.466 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.466 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.466 | |
| 4b10 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.466 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.465 | |
| 3k2h | LYA | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.465 | |
| 4irn | FAD | AnaB | / | 0.465 | |
| 1iid | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.464 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.464 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.464 | |
| 1w22 | NHB | Histone deacetylase 8 | 3.5.1.98 | 0.463 | |
| 3h0a | D30 | Peroxisome proliferator-activated receptor gamma | / | 0.463 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.463 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.463 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.463 | |
| 2i0z | FAD | NAD(FAD)-utilizing dehydrogenases | / | 0.462 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.462 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.462 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.462 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.462 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.461 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.461 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.461 | |
| 4ict | 1ED | Mycocyclosin synthase | 1.14.21.9 | 0.461 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.461 | |
| 5eow | FAD | 6-hydroxynicotinate 3-monooxygenase | 1.14.13.114 | 0.461 | |
| 2yek | EAM | Bromodomain-containing protein 2 | / | 0.460 | |
| 3gbk | 2PQ | Peroxisome proliferator-activated receptor gamma | / | 0.460 | |
| 3oct | 1N1 | Tyrosine-protein kinase BTK | 2.7.10.2 | 0.460 | |
| 3zuy | TCH | Transporter | / | 0.460 | |
| 4hw2 | 19H | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.460 | |
| 5ag7 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
| 1qvn | FRI | Interleukin-2 | / | 0.459 | |
| 2nu9 | COA | Succinate--CoA ligase [ADP-forming] subunit alpha | 6.2.1.5 | 0.459 | |
| 3t1a | 5MA | Gag-Pol polyprotein | 2.7.7.49 | 0.459 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.459 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.459 | |
| 4k2x | FAD | Polyketide oxygenase/hydroxylase | / | 0.459 | |
| 4la0 | 198 | Serum albumin | / | 0.459 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.459 | |
| 2c6h | PXI | Cytochrome P450 monooxygenase PikC | / | 0.458 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.458 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.458 | |
| 4ajp | 88N | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.458 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.458 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.458 | |
| 1e1k | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.457 | |
| 2ydw | WSH | Bromodomain-containing protein 2 | / | 0.457 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.457 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 4zp0 | DXC | Multidrug transporter MdfA | / | 0.457 | |
| 5ag5 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.456 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.456 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.456 | |
| 2vxo | XMP | GMP synthase [glutamine-hydrolyzing] | 6.3.5.2 | 0.456 | |
| 2w98 | P1Z | Prostaglandin reductase 2 | 1.3.1.48 | 0.456 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.456 | |
| 3sh0 | SAX | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.456 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.456 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.456 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.456 | |
| 5fsx | ADP | Uncharacterized protein | / | 0.456 | |
| 1do8 | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.455 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.455 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.455 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 2nsd | 4PI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.455 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.455 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.455 | |
| 4l8u | 9AZ | Serum albumin | / | 0.455 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 1gth | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.454 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.454 | |
| 1vru | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.454 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.454 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2xvd | AS6 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.454 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
| 3crz | FAD | Ferredoxin--NADP+ reductase | / | 0.454 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3sfi | 3SF | HTH-type transcriptional regulator EthR | / | 0.454 | |
| 3vso | EK1 | Peroxisome proliferator-activated receptor gamma | / | 0.454 | |
| 3x2v | ATP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.454 | |
| 4jaz | STL | Peroxisome proliferator-activated receptor gamma | / | 0.454 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.454 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.453 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.453 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.453 | |
| 2nmt | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.453 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.453 | |
| 2xk9 | XK9 | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.453 | |
| 3cr7 | PPS | Adenylyl-sulfate kinase | 2.7.1.25 | 0.453 | |
| 3g8e | IS1 | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.453 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.453 | |
| 3uyt | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.453 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.453 | |
| 3wy0 | COA | Uncharacterized protein | / | 0.453 | |
| 4a30 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.453 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4z9g | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.453 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.452 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 2gtk | 208 | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 3fmz | 2T1 | Retinol-binding protein 4 | / | 0.452 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.452 | |
| 3sgt | P09 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | / | 0.452 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.452 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.452 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.452 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.452 | |
| 1err | RAL | Estrogen receptor | / | 0.451 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.451 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.451 | |
| 2ie0 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 2uw0 | GVK | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.451 | |
| 2wsa | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.451 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.451 | |
| 3pgq | GY3 | Acetyl-CoA carboxylase | / | 0.451 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.451 | |
| 3wxy | COA | Uncharacterized protein | / | 0.451 | |
| 4b14 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.451 | |
| 4nr4 | 2LK | CREB-binding protein | / | 0.451 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.451 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.450 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.450 | |
| 2ya3 | J7V | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.450 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.450 | |
| 3i68 | J4Z | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.450 | |
| 3ics | COA | Coenzyme A disulfide reductase | / | 0.450 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.450 | |
| 4b2w | BZ0 | Glucose-1-phosphate thymidylyltransferase | / | 0.450 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.450 | |
| 4j57 | FAD | Thioredoxin reductase 2 | 1.8.1.9 | 0.450 | |
| 4jaq | COA | Alpha-pyrone synthesis polyketide synthase-like Pks11 | 2.3.1 | 0.450 | |
| 5hsa | FAS | Alcohol oxidase 1 | 1.1.3.13 | 0.450 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.450 | |
| 1mh1 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.449 | |
| 2uw5 | GVN | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 2vnh | FAD | NADPH:ferredoxin reductase | / | 0.449 | |
| 3c7q | XIN | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.449 | |
| 3ha3 | SAH | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.449 | |
| 3ls8 | AJZ | Phosphatidylinositol 3-kinase catalytic subunit type 3 | 2.7.1.137 | 0.449 | |
| 3stx | BKA | Methylketone synthase I | / | 0.449 | |
| 4a31 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.449 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.449 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.449 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.449 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.448 | |
| 1ppj | ANY | Cytochrome b | / | 0.448 | |
| 1vq1 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.448 | |
| 2cgu | 3A3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.448 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 2uw7 | GVP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3a14 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.448 | |
| 3i59 | N6S | CRP-like cAMP-activated global transcriptional regulator | / | 0.448 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.448 | |
| 3tdl | 11D | Serum albumin | / | 0.448 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.448 | |
| 4j4v | SVR | Nucleocapsid protein | / | 0.448 | |
| 4kio | G5K | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.448 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.448 | |
| 1buc | FAD | Acyl-CoA dehydrogenase, short-chain specific | 1.3.8.1 | 0.447 | |
| 1eyq | NAR | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.447 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.447 | |
| 1hon | GNH | Adenylosuccinate synthetase | / | 0.447 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.447 | |
| 1kuv | CA5 | Serotonin N-acetyltransferase | / | 0.447 | |
| 1n46 | PFA | Thyroid hormone receptor beta | / | 0.447 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.447 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.447 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.447 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 2uzw | SS4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.447 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 3e8e | G98 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.447 | |
| 3w4y | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.447 | |
| 4ag8 | AXI | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.447 | |
| 4dpm | COA | Malonyl-CoA reductase | 1.2.1.75 | 0.447 | |
| 4eil | CB3 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.447 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.447 | |
| 4hee | 14R | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.447 | |
| 4xye | NAD | Formate dehydrogenase | / | 0.447 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.447 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.447 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.446 | |
| 2o0u | C0M | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.446 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.446 | |
| 2yit | YIT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.446 | |
| 3ha7 | B32 | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.446 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.446 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.446 | |
| 3w2r | W2R | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4fta | H5K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.446 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.446 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.446 | |
| 1mb9 | ATP | Carboxyethyl-arginine beta-lactam-synthase | 6.3.3.4 | 0.445 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.445 | |
| 1ysx | 4EB | Serum albumin | / | 0.445 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.445 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2y3r | TRK | TamL | / | 0.445 | |
| 2ycf | YCF | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.445 | |
| 3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.445 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.445 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 3zbn | COA | 3-ketoacyl-CoA thiolase-like protein | / | 0.445 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.445 | |
| 4a4v | YFD | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 4c2x | NHW | Glycylpeptide N-tetradecanoyltransferase 2 | / | 0.445 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.445 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.445 | |
| 4qkn | JMS | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.445 | |
| 4wji | NAP | Putative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase | / | 0.445 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.445 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.445 | |
| 1c70 | L75 | Protease | / | 0.444 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1fm8 | DDC | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.444 | |
| 1fml | RTL | Retinol dehydratase | / | 0.444 | |
| 1llu | NAD | Alcohol dehydrogenase | / | 0.444 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.444 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.444 | |
| 2dwp | ACP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.444 | |
| 2vwy | 7X5 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.444 | |
| 2vx1 | 7X8 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.444 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.444 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 3eel | 53T | Uncharacterized protein | / | 0.444 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.444 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.444 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.444 | |
| 4c6z | TLE | 3-oxoacyl-ACP synthase | / | 0.444 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.444 | |
| 4fr4 | STU | Serine/threonine-protein kinase 32A | 2.7.11.1 | 0.444 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.444 | |
| 4lb2 | DM5 | Serum albumin | / | 0.444 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.444 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.444 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1cbr | REA | Cellular retinoic acid-binding protein 1 | / | 0.443 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.443 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.443 | |
| 1mgo | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 1o1v | TCH | Gastrotropin | / | 0.443 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1okz | UCN | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1rby | KEU | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.443 | |
| 1sn5 | T3 | Transthyretin | / | 0.443 | |
| 1t2d | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.443 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.443 | |
| 2ard | FDA | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.443 | |
| 2b03 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.443 | |
| 2c7g | FAD | NADPH-ferredoxin reductase FprA | 1.18.1.2 | 0.443 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2gek | GDP | Phosphatidyl-myo-inositol mannosyltransferase | 2.4.1.57 | 0.443 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.443 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2vo6 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 2vx0 | 7X7 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.443 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.443 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.443 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.443 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3ow3 | SMY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
| 3uku | C69 | Actin-related protein 3 | / | 0.443 | |
| 3upf | 0BU | Polyprotein | / | 0.443 | |
| 4b12 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4b1f | KRH | Glutamate racemase | / | 0.443 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.443 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.443 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.443 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.443 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.443 | |
| 4mcv | 29K | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.443 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.443 | |
| 5l7d | CLR | Smoothened homolog | / | 0.443 | |
| 1adc | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.442 | |
| 2c0o | L2G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.442 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.442 | |
| 2p4i | MR9 | Angiopoietin-1 receptor | 2.7.10.1 | 0.442 | |
| 2vnj | FAD | NADPH:ferredoxin reductase | / | 0.442 | |
| 2wes | FAD | Tryptophan 5-halogenase | / | 0.442 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.442 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.442 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 3kbo | NDP | Glyoxylate/hydroxypyruvate reductase A | / | 0.442 | |
| 3mla | JJZ | Probable nicotinate-nucleotide adenylyltransferase | / | 0.442 | |
| 3p3e | 3P3 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.442 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.442 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.442 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.442 | |
| 4fti | H7K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4g2h | 0VQ | Vitamin D3 receptor A | / | 0.442 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4ko8 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.442 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 5a27 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 5br4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.442 | |
| 5doz | NDP | JamJ | / | 0.442 | |
| 4k5y | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.442 | |
| 1axe | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 1e1m | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.441 | |
| 1h1s | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 1h74 | AGS | Homoserine kinase | 2.7.1.39 | 0.441 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.441 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.441 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1zx1 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.441 | |
| 2gu8 | 796 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.441 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.441 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.441 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.441 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.441 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.441 | |
| 3ict | COA | Coenzyme A disulfide reductase | / | 0.441 | |
| 3kdu | NKS | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 3ocg | OCG | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3q0g | BCO | Probable enoyl-CoA hydratase echA8 | 4.2.1.17 | 0.441 | |
| 3qpv | ADP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.441 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.441 | |
| 3we4 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 3zs5 | SB2 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4a32 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4em9 | TCE | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 4h3c | 0YZ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 4mxe | ACO | N-acetyltransferase ESCO1 | 2.3.1 | 0.441 | |
| 4xey | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.441 | |
| 1cbs | REA | Cellular retinoic acid-binding protein 2 | / | 0.440 | |
| 1h6v | NDP | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.440 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.440 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.440 | |
| 1jq5 | NAD | Glycerol dehydrogenase | 1.1.1.6 | 0.440 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.440 | |
| 1q3q | ANP | Thermosome subunit alpha | / | 0.440 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.440 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.440 | |
| 2hmy | SAM | Modification methylase HhaI | 2.1.1.37 | 0.440 | |
| 2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.440 | |
| 2vww | 7X2 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.440 | |
| 2xyn | VX6 | Abelson tyrosine-protein kinase 2 | 2.7.10.2 | 0.440 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.440 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.440 | |
| 3gob | HXX | DdmC | / | 0.440 | |
| 3q92 | XNB | Ketohexokinase | / | 0.440 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.440 | |
| 3tdk | NAD | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.440 | |
| 3vs3 | VSE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.440 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.440 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.440 | |
| 4c2z | MYA | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.440 | |
| 4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.440 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.440 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.440 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.440 | |
| 5c1g | GDU | Histo-blood group ABO system transferase | / | 0.440 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.440 |