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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3q67NAPAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3q67NAPAldose reductase1.1.1.211.000
3q65NAPAldose reductase1.1.1.210.699
2acqNAPAldose reductase1.1.1.210.474
1x96NAPAldose reductase1.1.1.210.464
1az2NAPAldose reductase1.1.1.210.454
2iq0NAPAldose reductase1.1.1.210.452
2pfhNDPAldose reductase1.1.1.210.451
3v36NAPAldose reductase1.1.1.210.450
2j8tNAPAldose reductase1.1.1.210.440