sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3q1f | YPP | Beta-lactamase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3q1f | YPP | Beta-lactamase | / | 1.000 | |
| 4de0 | 0JB | Beta-lactamase | / | 0.580 | |
| 3hlw | CE3 | Beta-lactamase | / | 0.575 | |
| 4de2 | DN3 | Beta-lactamase | / | 0.572 | |
| 4ddy | DN6 | Beta-lactamase | / | 0.568 | |
| 4de1 | 0J6 | Beta-lactamase | / | 0.548 | |
| 4de3 | DN8 | Beta-lactamase | / | 0.548 | |
| 4oaq | NDP | R-specific carbonyl reductase | / | 0.494 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.491 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.488 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.486 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.486 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.486 | |
| 4aux | XTC | Tetracycline repressor protein class D | / | 0.483 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.482 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.481 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.478 | |
| 4d7m | TDC | Tetracycline repressor protein class D | / | 0.478 | |
| 1zdw | FLV | Prenyltransferase | / | 0.477 | |
| 2o12 | FMN | Chorismate synthase | / | 0.477 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.475 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.475 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.475 | |
| 3fql | 79Z | Genome polyprotein | 2.7.7.48 | 0.475 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.475 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.474 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.474 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.474 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.473 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.473 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.473 | |
| 1e2n | RCA | Thymidine kinase | / | 0.472 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.472 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.472 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.471 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.471 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.471 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.471 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.471 | |
| 3wag | TYD | Glycosyltransferase | / | 0.470 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.469 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.469 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.469 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.469 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.469 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.468 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.468 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.468 | |
| 3b9l | AZZ | Serum albumin | / | 0.468 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.468 | |
| 4wri | OKA | Okadaic acid binding protein 2-alpha | / | 0.468 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.467 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.467 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.467 | |
| 2bxm | IMN | Serum albumin | / | 0.467 | |
| 2egb | SAH | Diphthine synthase | / | 0.467 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.467 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.466 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.466 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.466 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.466 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.466 | |
| 4rls | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.466 | |
| 5dp2 | NAP | CurF | / | 0.466 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.465 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.465 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.465 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.465 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.465 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.465 | |
| 3tdj | 3TJ | Glutamate receptor 2 | / | 0.465 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.465 | |
| 4nxx | GDP | Mitochondrial dynamics protein MID51 | / | 0.465 | |
| 1ork | ATC | Tetracycline repressor protein class D | / | 0.464 | |
| 2p5c | SAH | Diphthine synthase | / | 0.464 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.464 | |
| 4bqh | 9VU | UDP-N-acetylglucosamine pyrophosphorylase, putative | / | 0.464 | |
| 4u3j | GTP | Tubulin beta chain | / | 0.464 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.463 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.463 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.463 | |
| 3udk | 095 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.463 | |
| 4xqc | NAD | Homospermidine synthase | 2.5.1.44 | 0.463 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.463 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.462 | |
| 2d8a | NAD | L-threonine 3-dehydrogenase | / | 0.462 | |
| 2fa3 | ACO | Hydroxymethylglutaryl-CoA synthase | / | 0.462 | |
| 2o7o | DXT | Tetracycline repressor protein class D | / | 0.462 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.462 | |
| 3ieu | GDP | GTPase Era | / | 0.462 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.462 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.461 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.461 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.461 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.461 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.461 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.460 | |
| 2r6g | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.460 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.460 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.460 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.460 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.459 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.459 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.459 | |
| 2ejk | SAH | Diphthine synthase | / | 0.459 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.459 | |
| 2p5f | SAH | Diphthine synthase | / | 0.459 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.459 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.459 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.459 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.459 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.459 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.459 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.458 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.458 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.458 | |
| 2owk | SAH | Diphthine synthase | / | 0.458 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.458 | |
| 3iup | NDP | Possible NADH oxidoreductase | / | 0.458 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.458 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.458 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.458 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.458 | |
| 4l4x | NDP | AmphI | / | 0.458 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.458 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.458 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.457 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.457 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.457 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.457 | |
| 2owu | SAH | Diphthine synthase | / | 0.457 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.457 | |
| 4xq6 | FMN | Dihydroorotate dehydrogenase (quinone) | / | 0.457 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.456 | |
| 1wng | SAH | Diphthine synthase | / | 0.456 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.456 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.456 | |
| 2djl | FMN | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.456 | |
| 2el0 | SAH | Diphthine synthase | / | 0.456 | |
| 2emr | SAH | Diphthine synthase | / | 0.456 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.456 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.456 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.456 | |
| 2p6i | SAH | Diphthine synthase | / | 0.456 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.456 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.456 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.456 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.455 | |
| 2dsh | SAH | Diphthine synthase | / | 0.455 | |
| 2en5 | SAH | Diphthine synthase | / | 0.455 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.455 | |
| 2pci | SAH | Diphthine synthase | / | 0.455 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.455 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.455 | |
| 4kwh | NAP | Reductase homolog | / | 0.455 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.455 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.455 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.454 | |
| 2egs | SAH | Diphthine synthase | / | 0.454 | |
| 2eni | SAH | Diphthine synthase | / | 0.454 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.454 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.454 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.454 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.454 | |
| 3d8b | ADP | Fidgetin-like protein 1 | 3.6.4 | 0.454 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.454 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.454 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.454 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.453 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.453 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.453 | |
| 2cvz | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.453 | |
| 2dxx | SAH | Diphthine synthase | / | 0.453 | |
| 2e16 | SAH | Diphthine synthase | / | 0.453 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.453 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.453 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.453 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.453 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 4n9i | PCG | Catabolite expression activator | / | 0.453 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1eq2 | ADQ | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.452 | |
| 2e07 | SAH | Diphthine synthase | / | 0.452 | |
| 2e17 | SAH | Diphthine synthase | / | 0.452 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.452 | |
| 2jcx | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.452 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.452 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.452 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.452 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.452 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.452 | |
| 4u7w | NDP | MxaA | / | 0.452 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.451 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.451 | |
| 1o0s | NAI | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.451 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.451 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.451 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.451 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.451 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.451 | |
| 3h6v | NS6 | Glutamate receptor 2 | / | 0.451 | |
| 3nbv | ANP | Ketohexokinase | / | 0.451 | |
| 4f6r | GDP | Tubulin beta chain | / | 0.451 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.450 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.450 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.450 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.450 | |
| 1wp4 | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.450 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.450 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.450 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.450 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.450 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.450 | |
| 3k4c | FAD | Pyranose 2-oxidase | / | 0.450 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.450 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.450 | |
| 3r95 | ACO | MccE protein | / | 0.450 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.450 | |
| 3zhr | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.450 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.450 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.450 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.449 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.449 | |
| 2emu | SAH | Diphthine synthase | / | 0.449 | |
| 2onm | ADP | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.449 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.449 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.449 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.449 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.449 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.449 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.449 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 4iaw | LIZ | Neutrophil gelatinase-associated lipocalin | / | 0.449 | |
| 4nu5 | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.449 | |
| 5fkm | TDC | Tetracycline repressor protein class D | / | 0.449 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.448 | |
| 1d0l | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.448 | |
| 1eq2 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.448 | |
| 1h47 | C5P | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.448 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.448 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.448 | |
| 2egl | SAH | Diphthine synthase | / | 0.448 | |
| 2eka | SAH | Diphthine synthase | / | 0.448 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.448 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.448 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.448 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.448 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.448 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.448 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.448 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.448 | |
| 3uce | NDP | Dehydrogenase | / | 0.448 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.448 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.448 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 4ozn | ATP | Ammonium transporter | / | 0.448 | |
| 4qec | NAP | ElxO | / | 0.448 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.448 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.447 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.447 | |
| 2qo7 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.447 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.447 | |
| 3e23 | SAM | Uncharacterized protein | / | 0.447 | |
| 3ivx | FG6 | Pantothenate synthetase | 6.3.2.1 | 0.447 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.447 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.447 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.447 | |
| 3rj5 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.447 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.447 | |
| 1d4d | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.446 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.446 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.446 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.446 | |
| 1qf5 | RPL | Adenylosuccinate synthetase | / | 0.446 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.446 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 1vji | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.446 | |
| 1y9d | TPP | Pyruvate oxidase | 1.2.3.3 | 0.446 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.446 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.446 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.446 | |
| 2f3m | GTD | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.446 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2pcm | SAH | Diphthine synthase | / | 0.446 | |
| 2qs1 | UB1 | Glutamate receptor ionotropic, kainate 1 | / | 0.446 | |
| 2trt | TAC | Tetracycline repressor protein class D | / | 0.446 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 2x0r | NAD | Malate dehydrogenase | / | 0.446 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.446 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.446 | |
| 3i6q | NDP | Putative leucoanthocyanidin reductase 1 | / | 0.446 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.446 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.446 | |
| 3qvi | K95 | HAP protein | / | 0.446 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.446 | |
| 3uqd | ADP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.446 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.446 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.446 | |
| 4iax | LIZ | Neutrophil gelatinase-associated lipocalin | / | 0.446 | |
| 5fko | TDC | Tetracycline repressor protein class D | / | 0.446 | |
| 5ftf | ADP | TPR domain protein | / | 0.446 | |
| 1h74 | AGS | Homoserine kinase | 2.7.1.39 | 0.445 | |
| 1jzq | ILA | Isoleucine--tRNA ligase | 6.1.1.5 | 0.445 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.445 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.445 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.445 | |
| 2ag1 | TPP | Benzaldehyde lyase | / | 0.445 | |
| 2dxv | SAH | Diphthine synthase | / | 0.445 | |
| 2e4n | SAH | Diphthine synthase | / | 0.445 | |
| 2g76 | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.445 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.445 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.445 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.445 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.445 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.445 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.445 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.445 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.445 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.444 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.444 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.444 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.444 | |
| 2e8h | SAH | Diphthine synthase | / | 0.444 | |
| 2e8q | SAH | Diphthine synthase | / | 0.444 | |
| 2eeq | SAH | Diphthine synthase | / | 0.444 | |
| 2ejz | SAH | Diphthine synthase | / | 0.444 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.444 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.444 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.444 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.444 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.444 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.444 | |
| 3axk | NDP | Ribulose bisphosphate carboxylase large chain | 4.1.1.39 | 0.444 | |
| 3e39 | FMN | Nitroreductase | / | 0.444 | |
| 4ac0 | MIY | Tetracycline repressor protein class B from transposon Tn10 | / | 0.444 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 5fl3 | ADP | Pili retraction protein PilT | / | 0.444 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.443 | |
| 1gc5 | ADP | ADP-dependent glucokinase | 2.7.1.147 | 0.443 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.443 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.443 | |
| 2e15 | SAH | Diphthine synthase | / | 0.443 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.443 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.443 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 2p2x | SAH | Diphthine synthase | / | 0.443 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.443 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.443 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.443 | |
| 3a3y | OBN | Sodium/potassium-transporting ATPase subunit alpha | / | 0.443 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.443 | |
| 3kej | 3EJ | Collagenase 3 | 3.4.24 | 0.443 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.443 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.443 | |
| 4iji | 99T | Glutathione S-transferase-like protein YibF | / | 0.443 | |
| 4mkh | AP5 | Adenylate kinase | / | 0.443 | |
| 4qak | 2AM | RNA 2',3'-cyclic phosphodiesterase | / | 0.443 | |
| 4xrg | NAD | Homospermidine synthase | 2.5.1.44 | 0.443 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.443 | |
| 5er0 | FAD | Uncharacterized NAD(FAD)-dependent dehydrogenase | / | 0.443 | |
| 1a8r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.442 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.442 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.442 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.442 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.442 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 1zmd | NAI | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.442 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.442 | |
| 2dsi | SAH | Diphthine synthase | / | 0.442 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.442 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 2ii6 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.442 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.442 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.442 | |
| 2owv | SAH | Diphthine synthase | / | 0.442 | |
| 2p6l | SAH | Diphthine synthase | / | 0.442 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.442 | |
| 2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3c21 | 2BA | DNA integrity scanning protein DisA | / | 0.442 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.442 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.442 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.442 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.442 | |
| 3x21 | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.442 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.442 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.442 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.442 | |
| 4i9n | 1E5 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.442 | |
| 4mfe | BTN | Pyruvate carboxylase | / | 0.442 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.442 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.442 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.442 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.442 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.442 | |
| 1bmd | NAD | Malate dehydrogenase | / | 0.441 | |
| 1ee9 | NAD | Methylenetetrahydrofolate dehydrogenase [NAD(+)] | 1.5.1.15 | 0.441 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.441 | |
| 1i5z | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.441 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.441 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 1tys | DHF | Thymidylate synthase | / | 0.441 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.441 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.441 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.441 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.441 | |
| 2eld | SAH | Diphthine synthase | / | 0.441 | |
| 2ele | SAH | Diphthine synthase | / | 0.441 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2p6k | SAH | Diphthine synthase | / | 0.441 | |
| 2w6m | OA1 | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.441 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.441 | |
| 3ll9 | ADP | Isopentenyl phosphate kinase | / | 0.441 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.441 | |
| 3zho | FMN | NAD(P)H dehydrogenase (quinone) | / | 0.441 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.441 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.441 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.441 | |
| 4emt | C2E | Stimulator of interferon genes protein | / | 0.441 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.441 | |
| 4hmv | WUB | Phenazine biosynthesis protein PhzG | 1.4 | 0.441 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.441 | |
| 5fkl | TDC | Tetracycline repressor protein class D | / | 0.441 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.440 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.440 | |
| 2g2z | COZ | Malonyl CoA-acyl carrier protein transacylase | 2.3.1.39 | 0.440 | |
| 2pch | SAH | Diphthine synthase | / | 0.440 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2z3l | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.440 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.440 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.440 | |
| 3dj4 | UD1 | Bifunctional protein GlmU | / | 0.440 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.440 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.440 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.440 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.440 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.440 | |
| 4ike | ADP | Adenylate kinase | / | 0.440 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.440 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.440 | |
| 4xfj | ANP | Argininosuccinate synthase | / | 0.440 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.440 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.440 | |
| 5f54 | TMP | Single-stranded-DNA-specific exonuclease | / | 0.440 |