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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.11.000
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.620
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.555
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.492
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.489
3cr0809Wee1-like protein kinase2.7.10.20.483
2in6839Wee1-like protein kinase2.7.10.20.470
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.462
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.459
3cqeP91Wee1-like protein kinase2.7.10.20.456
3biz61EWee1-like protein kinase2.7.10.20.449
3bi6396Wee1-like protein kinase2.7.10.20.448
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.445
3rsv3RSBeta-secretase 13.4.23.460.444
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.443