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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3plsANPMacrophage-stimulating protein receptor2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3plsANPMacrophage-stimulating protein receptor2.7.10.11.000
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.559
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.557
1b38ATPCyclin-dependent kinase 22.7.11.220.531
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.527
1b39ATPCyclin-dependent kinase 22.7.11.220.525
5cnnANPEpidermal growth factor receptor2.7.10.10.522
1qmzATPCyclin-dependent kinase 22.7.11.220.516
4k2rANPTyrosine-protein kinase ZAP-702.7.10.20.511
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.505
1hckATPCyclin-dependent kinase 22.7.11.220.504
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.502
2ozoANPTyrosine-protein kinase ZAP-702.7.10.20.501
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.501
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.495
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.495
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.494
2cjmATPCyclin-dependent kinase 22.7.11.220.493
5cnoANPEpidermal growth factor receptor2.7.10.10.493
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.492
1i44ACPInsulin receptor2.7.10.10.491
1jstATPCyclin-dependent kinase 22.7.11.220.491
3c4wATPRhodopsin kinase/0.491
4qnyANPMitogen activated protein kinase, putative/0.490
4ysjADPCalmodulin-like domain protein kinase/0.489
1dayGNPCasein kinase II subunit alpha2.7.11.10.487
1w8cN69Cyclin-dependent kinase 22.7.11.220.485
4qmlANPSerine/threonine-protein kinase 242.7.11.10.482
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.481
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
2w4jADPDeath-associated protein kinase 12.7.11.10.480
3bu5ATPInsulin receptor2.7.10.10.480
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.480
1ictT44Transthyretin/0.477
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.477
3c4zADPRhodopsin kinase/0.477
3qc9ADPRhodopsin kinase/0.476
4i3zADPCyclin-dependent kinase 22.7.11.220.476
4lrjANPUncharacterized protein/0.476
4jrnANPRhoptry kinase family protein/0.475
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.474
3orpAGSSerine/threonine protein kinase/0.472
4bbe3O4Tyrosine-protein kinase JAK2/0.471
4ii5ADPCyclin-dependent kinase 22.7.11.220.471
1px2ATPSynapsin-1/0.470
3nieANPMitogen-activated protein kinase/0.470
4k33ACPFibroblast growth factor receptor 32.7.10.10.470
1finATPCyclin-dependent kinase 22.7.11.220.469
1ig1ANPDeath-associated protein kinase 12.7.11.10.469
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.469
2bxiAZQSerum albumin/0.466
2henADPEphrin type-B receptor 22.7.10.10.466
2c5yMTWCyclin-dependent kinase 22.7.11.220.465
2c6o4SPCyclin-dependent kinase 22.7.11.220.465
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.464
4l9i8PRRhodopsin kinase/0.464
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.464
4xlvACPInsulin receptor2.7.10.10.463
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.463
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.462
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.462
1f8sFADL-amino-acid oxidase1.4.3.20.461
1jqhANPInsulin-like growth factor 1 receptor2.7.10.10.461
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.460
4crsAGSSerine/threonine-protein kinase N22.7.11.130.460
4lfiGNPCasein kinase II subunit alpha2.7.11.10.460
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.459
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.459
2w2lNADD-mandelate dehydrogenase/0.459
4wq5ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.459
2etm7PYFocal adhesion kinase 12.7.10.20.458
2vtqLZACyclin-dependent kinase 22.7.11.220.458
1jkkANPDeath-associated protein kinase 12.7.11.10.457
2qoqANPEphrin type-A receptor 32.7.10.10.457
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2y9qANPMitogen-activated protein kinase 12.7.11.240.457
3gu7ADPDeath-associated protein kinase 12.7.11.10.457
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.457
3c4xATPRhodopsin kinase/0.456
3fhyATPPyridoxal kinase2.7.1.350.456
2cbsR13Cellular retinoic acid-binding protein 2/0.455
3keuATPPyridoxal kinase2.7.1.350.455
3o7lANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
3ortAGSSerine/threonine protein kinase/0.455
3zh8C58Protein kinase C iota type2.7.11.130.455
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
2a19ANPInterferon-induced, double-stranded RNA-activated protein kinase2.7.11.10.454
4eooATPCyclin-dependent kinase 22.7.11.220.454
2vtsLZCCyclin-dependent kinase 22.7.11.220.453
4deeADPAurora kinase A2.7.11.10.453
4jia1K3Tyrosine-protein kinase JAK2/0.453
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.453
5dnrATPAurora kinase A2.7.11.10.453
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.452
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.452
2w5aADPSerine/threonine-protein kinase Nek22.7.11.10.452
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.452
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.451
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.451
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.451
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.451
4ic7ANPMitogen-activated protein kinase 72.7.11.240.451
3vn9ANKDual specificity mitogen-activated protein kinase kinase 62.7.12.20.450
1o6kANPRAC-beta serine/threonine-protein kinase2.7.11.10.449
2j0lANPFocal adhesion kinase 12.7.10.20.449
2oorNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.449
3x2uATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3x2vATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
1ir3ANPInsulin receptor2.7.10.10.448
4j95ACPFibroblast growth factor receptor 2/0.448
1wc1TATAdenylate cyclase/0.447
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2ijmATPFocal adhesion kinase 12.7.10.20.447
5ap7SVEDual specificity protein kinase TTK2.7.12.10.447
2ghmLICMitogen-activated protein kinase 14/0.446
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3hkoANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands/0.446
4ez50RSCyclin-dependent kinase 62.7.11.220.446
1rkxNADCDP-D-glucose-4,6-dehydratase/0.445
4bcmT7ZCyclin-dependent kinase 22.7.11.220.445
5eg3ACPFibroblast growth factor receptor 2/0.445
5l8lADPAurora kinase A2.7.11.10.445
1g5sI17Cyclin-dependent kinase 22.7.11.220.444
4xhgADPUncharacterized protein/0.444
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.443
1pmn984Mitogen-activated protein kinase 102.7.11.240.443
2wqeADPAurora kinase A2.7.11.10.443
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3crlANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.442
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.442
4j99ACPFibroblast growth factor receptor 2/0.442
4u03GTPCyclic GMP-AMP synthase/0.442
2qo7ANPEphrin type-A receptor 32.7.10.10.441
3cgfJNFMitogen-activated protein kinase 102.7.11.240.441
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.441
4ix5ANPUncharacterized protein/0.441
3t8oATPRhodopsin kinase/0.440
4n9wGDPPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.440