sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3p7a | P7A | Mitogen-activated protein kinase 14 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3p7a | P7A | Mitogen-activated protein kinase 14 | / | 1.000 | |
| 1kv2 | B96 | Mitogen-activated protein kinase 14 | / | 0.654 | |
| 3uvr | 06F | Mitogen-activated protein kinase 14 | / | 0.635 | |
| 2yis | YIS | Mitogen-activated protein kinase 14 | / | 0.613 | |
| 3p7b | P7B | Mitogen-activated protein kinase 14 | / | 0.588 | |
| 3lfb | Z87 | Mitogen-activated protein kinase 14 | / | 0.566 | |
| 3gcu | R48 | Mitogen-activated protein kinase 14 | / | 0.555 | |
| 3hv6 | R39 | Mitogen-activated protein kinase 14 | / | 0.551 | |
| 3p7c | P7C | Mitogen-activated protein kinase 14 | / | 0.551 | |
| 2puu | G2G | Mitogen-activated protein kinase 14 | / | 0.547 | |
| 1kv1 | BMU | Mitogen-activated protein kinase 14 | / | 0.533 | |
| 3npc | B96 | Mitogen-activated protein kinase 9 | 2.7.11.24 | 0.531 | |
| 3nnu | EDB | Mitogen-activated protein kinase 14 | / | 0.530 | |
| 3nnw | EDD | Mitogen-activated protein kinase 14 | / | 0.527 | |
| 3o8u | BMU | Mitogen-activated protein kinase 14 | / | 0.525 | |
| 1w82 | L10 | Mitogen-activated protein kinase 14 | / | 0.518 | |
| 3nnx | EDD | Mitogen-activated protein kinase 14 | / | 0.516 | |
| 3gi3 | B10 | Mitogen-activated protein kinase 14 | / | 0.514 | |
| 3p5k | P5K | Mitogen-activated protein kinase 14 | / | 0.514 | |
| 3lff | Z83 | Mitogen-activated protein kinase 14 | / | 0.513 | |
| 2yiw | YIW | Mitogen-activated protein kinase 14 | / | 0.511 | |
| 3k3j | F4C | Mitogen-activated protein kinase 14 | / | 0.508 | |
| 3gcv | SS6 | Mitogen-activated protein kinase 14 | / | 0.507 | |
| 1wbt | WBT | Mitogen-activated protein kinase 14 | / | 0.505 | |
| 1wbs | LI2 | Mitogen-activated protein kinase 14 | / | 0.502 | |
| 3hv7 | 1AU | Mitogen-activated protein kinase 14 | / | 0.502 | |
| 4l8m | F46 | Mitogen-activated protein kinase 14 | / | 0.492 | |
| 3hv4 | L51 | Mitogen-activated protein kinase 14 | / | 0.491 | |
| 4h1m | 0YJ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.489 | |
| 4eh9 | 0OQ | Mitogen-activated protein kinase 14 | / | 0.488 | |
| 3p79 | P79 | Mitogen-activated protein kinase 14 | / | 0.480 | |
| 2fde | 385 | Gag-Pol polyprotein | 3.4.23.16 | 0.476 | |
| 2uw6 | GVO | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.476 | |
| 2v51 | LAB | Actin, alpha skeletal muscle | / | 0.476 | |
| 3rga | LSB | Epoxide hydrolase LasB | 5.5.1 | 0.471 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.470 | |
| 2f3k | RO1 | Protease | / | 0.469 | |
| 3el9 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.468 | |
| 3p78 | P78 | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 3amb | VX6 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.467 | |
| 1wbv | LI3 | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 3nxe | 2NC | Protease | / | 0.466 | |
| 3dfc | ANP | Death-associated protein kinase 1 | 2.7.11.1 | 0.465 | |
| 1t3r | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.464 | |
| 3h0s | B38 | Acetyl-CoA carboxylase | / | 0.463 | |
| 2uw4 | L15 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
| 3e93 | 19B | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 4fsq | HK3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 4j5j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 2v52 | LAB | Actin, alpha skeletal muscle | / | 0.461 | |
| 3ndt | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 2i4v | DJR | V-1 protease | / | 0.459 | |
| 3ldg | SAH | Uncharacterized protein | / | 0.459 | |
| 3vs7 | KS1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.459 | |
| 1dif | A85 | Gag-Pol polyprotein | / | 0.458 | |
| 2c0t | L3G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.458 | |
| 3gc8 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.458 | |
| 3pwr | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 3s56 | ROC | Protease | / | 0.456 | |
| 4b1v | LAB | Actin, alpha skeletal muscle | / | 0.456 | |
| 4ftk | H9K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 1zhw | HC2 | Oxysterol-binding protein homolog 4 | / | 0.455 | |
| 2bpv | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 2pk5 | 075 | Protease | / | 0.455 | |
| 2r0u | M54 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 2rkf | AB1 | Pol protein | / | 0.455 | |
| 3nu9 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 3t54 | ATP | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 | / | 0.455 | |
| 1dw6 | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 3anl | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.454 | |
| 3el1 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 3em4 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 3ggx | GGX | Gag-Pol polyprotein | / | 0.454 | |
| 3saa | 77F | Protease | / | 0.454 | |
| 1ohr | 1UN | V-1 PROTEASE protein | / | 0.453 | |
| 1ydr | IQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.453 | |
| 2c6e | HPM | Aurora kinase A | 2.7.11.1 | 0.453 | |
| 2qnn | QN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 3ekq | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 2b52 | D42 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 3ugc | 046 | Tyrosine-protein kinase JAK2 | / | 0.452 | |
| 3vhe | 42Q | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.452 | |
| 3wze | BAX | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.452 | |
| 4ylh | YE1 | (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase | / | 0.452 | |
| 1hpx | KNI | Gag-Pol polyprotein | / | 0.451 | |
| 1yt9 | OIS | Gag-Pol polyprotein | / | 0.451 | |
| 2uzu | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.451 | |
| 3qlf | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.451 | |
| 3rus | ADP | Chaperonin | / | 0.451 | |
| 3vrz | VRZ | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.451 | |
| 3vs1 | VSA | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.451 | |
| 4h0y | LAR | Actin, alpha skeletal muscle | / | 0.451 | |
| 1d4y | TPV | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 1hsg | MK1 | Gag-Pol polyprotein | / | 0.450 | |
| 1k1u | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 2fdd | 385 | Pol protein | / | 0.450 | |
| 3zo1 | SIJ | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 4fp9 | SAM | 5-methylcytosine rRNA methyltransferase NSUN4 | 2.1.1 | 0.450 | |
| 4z9r | NAD | Omega-3 polyunsaturated fatty acid synthase subunit PfaD | / | 0.450 | |
| 5j4e | FMN | Sensory box protein | / | 0.450 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.450 | |
| 1ec2 | BEJ | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 1hxw | RIT | Gag-Pol polyprotein | / | 0.449 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 1q8w | M77 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 2avm | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 4j55 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 4k4p | 3TL | Gag-Pol polyprotein | / | 0.449 | |
| 5j3w | FMN | Sensory box protein | / | 0.449 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.448 | |
| 2oh0 | 2PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 2uw0 | GVK | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 3s85 | LK0 | Gag-Pol polyprotein | / | 0.448 | |
| 4nka | 2K7 | Fibroblast growth factor receptor 1 | / | 0.448 | |
| 1ckp | PVB | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 2j0m | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.447 | |
| 2pk6 | O33 | V-1 protease | / | 0.447 | |
| 2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 3lu6 | IMX | Serum albumin | / | 0.447 | |
| 3umv | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.447 | |
| 4fsu | HK5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 4fti | H7K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 4j54 | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1bvg | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1hpo | UNI | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1meu | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1sdv | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 2bpy | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 2cem | 2AH | Pol protein | / | 0.446 | |
| 2qfx | NDP | Isocitrate dehydrogenase [NADP], mitochondrial | 1.1.1.42 | 0.446 | |
| 3dcr | KVS | Protease | / | 0.446 | |
| 3el4 | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3lpb | NVB | Tyrosine-protein kinase JAK2 | / | 0.446 | |
| 3zcw | 4A2 | Kinesin-like protein KIF11 | / | 0.446 | |
| 4oh4 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.446 | |
| 2aid | THK | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2bpz | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3hzc | 2NC | Protease | / | 0.445 | |
| 3orp | AGS | Serine/threonine protein kinase | / | 0.445 | |
| 4wbb | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 5hid | B1E | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.445 | |
| 1fff | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1ida | 0PO | Gag-Pol polyprotein | 3.4.23.47 | 0.444 | |
| 1rfq | LAR | Actin, alpha skeletal muscle | / | 0.444 | |
| 2cen | 4AH | Protease | / | 0.444 | |
| 2q64 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 2vo3 | M04 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 2w0j | ZAT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.444 | |
| 2y02 | Y01 | Beta-1 adrenergic receptor | / | 0.444 | |
| 2yiq | YIQ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.444 | |
| 3lu7 | IPX | Serum albumin | / | 0.444 | |
| 3u2x | ASO | Glycogenin-1 | 2.4.1.186 | 0.444 | |
| 4bbf | O19 | Tyrosine-protein kinase JAK2 | / | 0.444 | |
| 4ft5 | H2K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 1b6m | PI6 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1bai | 0Q4 | Gag-Pro polyprotein | / | 0.443 | |
| 1d4l | PI9 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1hvj | A78 | Gag-Pol polyprotein | / | 0.443 | |
| 1izh | Q50 | Protease | / | 0.443 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2x1n | X1N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3d83 | GK6 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3i2l | 2NC | Protease | / | 0.443 | |
| 3os3 | 3OS | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.443 | |
| 4dqb | 017 | Gag-Pol polyprotein | / | 0.443 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 4wlu | NAD | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.443 | |
| 2qak | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2upj | U02 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2ycq | UPX | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.442 | |
| 3ekt | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3t3c | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 4f64 | 0S8 | Fibroblast growth factor receptor 1 | / | 0.442 | |
| 1daz | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1hvl | A76 | Gag-Pol polyprotein | / | 0.441 | |
| 2bqv | A1A | Protease | / | 0.441 | |
| 2e2b | 406 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.441 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.441 | |
| 2uzt | SS3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 3bxs | DRS | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3d1x | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3jvw | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.441 | |
| 4b1u | LAB | Actin, alpha skeletal muscle | / | 0.441 | |
| 4djo | MK5 | Pol polyprotein | / | 0.441 | |
| 4f6s | 0SQ | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.441 | |
| 4fsz | HK8 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4hdp | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4lgh | 0JN | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.441 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.441 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1h1s | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1hvs | A77 | Gag-Pol polyprotein | / | 0.440 | |
| 1nvf | ADP | Pentafunctional AROM polypeptide | / | 0.440 | |
| 1wbn | L09 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 1z1h | HBB | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2bts | U32 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2bx8 | AZQ | Serum albumin | / | 0.440 | |
| 2fzm | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.440 | |
| 2y01 | Y01 | Beta-1 adrenergic receptor | / | 0.440 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 3bgc | LJH | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3cqw | CQW | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.440 | |
| 3lzu | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3nyn | SGV | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.440 | |
| 3zpt | M8Y | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 4bc6 | XZN | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.440 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.440 | |
| 5cnn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 4z35 | ON9 | Lysophosphatidic acid receptor 1 | / | 0.440 |