sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3p2v | DOY | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 1.000 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.667 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.645 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.629 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.620 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.619 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.618 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.612 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.609 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.606 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.606 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.605 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.601 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.600 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.595 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.590 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.581 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.574 | |
| 1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.564 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.562 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.557 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.555 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.551 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.551 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.550 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.542 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.532 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.525 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.521 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.520 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.516 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.516 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.515 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.514 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.514 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.513 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.512 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.512 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.512 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.511 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.511 | |
| 3ugr | IMN | Aldo-keto reductase family 1 member C3 | / | 0.511 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.509 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.507 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.507 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.506 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.505 | |
| 2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.504 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.502 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.502 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.502 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.502 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.501 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.500 | |
| 3ocw | 3AM | Lipoprotein E | / | 0.500 | |
| 3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.500 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.499 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.499 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.498 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.497 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.497 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.497 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.497 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.496 | |
| 1sg0 | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.496 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.496 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.495 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.495 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.495 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.495 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.494 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.494 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.493 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.493 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.493 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.493 | |
| 3t0k | DCQ | Sulfide-quinone reductase | / | 0.492 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.492 | |
| 1dpm | EBP | Parathion hydrolase | 3.1.8.1 | 0.491 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.491 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.491 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.491 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.491 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.490 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.490 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.490 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.490 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.490 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.490 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.489 | |
| 3ocx | 2AM | Lipoprotein E | / | 0.489 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.489 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.489 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.488 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.488 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.487 | |
| 3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.487 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.487 | |
| 4g2w | NI0 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.487 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.487 | |
| 4nwi | CTN | 7-methylguanosine phosphate-specific 5'-nucleotidase | / | 0.487 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.486 | |
| 1g3m | PCQ | Estrogen sulfotransferase | 2.8.2.4 | 0.486 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.486 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.486 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.486 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.486 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 4yfy | 0FX | VioF | / | 0.486 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.485 | |
| 1rxj | BNI | Streptavidin | / | 0.485 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.485 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.485 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.485 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.484 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.484 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.484 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.484 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.484 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.483 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.483 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.483 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.483 | |
| 2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.483 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.483 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.483 | |
| 4l6s | 1WQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.483 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.483 | |
| 4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.483 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.482 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.482 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.481 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.481 | |
| 1az1 | ALR | Aldose reductase | 1.1.1.21 | 0.480 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.480 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.480 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.480 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.480 | |
| 4j7g | TRH | PCZA361.3 | / | 0.480 | |
| 4kn0 | MTX | Folate receptor beta | / | 0.480 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.479 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.479 | |
| 2iuz | D1H | Endochitinase B1 | 3.2.1.14 | 0.479 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.479 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.478 | |
| 1tfz | 869 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.478 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.478 | |
| 2xyt | TC9 | Soluble acetylcholine receptor | / | 0.478 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.478 | |
| 4g8c | C6L | Alpha/beta hydrolase fold protein | / | 0.478 | |
| 3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.477 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.477 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.477 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.477 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.476 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.476 | |
| 3szf | DCQ | Sulfide-quinone reductase | / | 0.476 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.476 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.476 | |
| 4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.476 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 3h4g | FID | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.475 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.475 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.475 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.475 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.474 | |
| 2bd0 | BIO | Sepiapterin reductase | / | 0.474 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.474 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.474 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.474 | |
| 3qfr | FAD | NADPH--cytochrome P450 reductase | / | 0.474 | |
| 3t31 | DCQ | Sulfide-quinone reductase | / | 0.474 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.474 | |
| 5cto | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.474 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 2dsc | APR | ADP-sugar pyrophosphatase | 3.6.1.13 | 0.473 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.473 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.473 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 4h7c | 10H | Aldo-keto reductase family 1 member C3 | / | 0.473 | |
| 4jvm | XDI | Estrogen sulfotransferase | 2.8.2.4 | 0.473 | |
| 4lcw | 1VY | Major histocompatibility complex class I-related gene protein | / | 0.473 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.472 | |
| 1xid | ASC | Xylose isomerase | 5.3.1.5 | 0.472 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 2nvd | ITB | Aldose reductase | 1.1.1.21 | 0.472 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.472 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.472 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.472 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.471 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.471 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.471 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.471 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.471 | |
| 3r8g | IZP | Aldo-keto reductase family 1 member C3 | / | 0.471 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.471 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.471 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.471 | |
| 4jvn | YUG | Estrogen sulfotransferase | 2.8.2.4 | 0.471 | |
| 1w76 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.470 | |
| 4bmp | FMN | Protein NrdI | / | 0.470 | |
| 5dsy | UHB | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.470 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.470 | |
| 1t47 | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.469 | |
| 1uk1 | FRQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.469 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.469 | |
| 2xlt | NA0 | Putative flavin-containing monooxygenase | / | 0.469 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 3c1o | NAP | Eugenol synthase | / | 0.469 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.469 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.469 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.468 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.468 | |
| 3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.468 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.468 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.468 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.468 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.467 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.467 | |
| 3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
| 4j7h | TRH | PCZA361.3 | / | 0.467 | |
| 2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.466 | |
| 2x86 | ADP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.466 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.466 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.466 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.465 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.465 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.465 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.465 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.465 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 1isj | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.464 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.464 | |
| 2f0y | 3MN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.464 | |
| 2qjp | ANJ | Cytochrome b | / | 0.464 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.464 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.464 | |
| 5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.464 | |
| 1sjw | NGV | Nogalonic acid methyl ester cyclase | / | 0.463 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.463 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.463 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.463 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.463 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 3hyw | DCQ | Sulfide-quinone reductase | / | 0.463 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.463 | |
| 3w0t | HPU | Lactoylglutathione lyase | 4.4.1.5 | 0.463 | |
| 4fal | 0T0 | Aldo-keto reductase family 1 member C3 | / | 0.463 | |
| 1dls | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1s2c | FLF | Aldo-keto reductase family 1 member C3 | / | 0.462 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.462 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.462 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.462 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.462 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.462 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.462 | |
| 3gsi | THG | Dimethylglycine oxidase | 1.5.3.10 | 0.462 | |
| 3o9l | LPN | Renin | 3.4.23.15 | 0.462 | |
| 3r7m | SUZ | Aldo-keto reductase family 1 member C3 | / | 0.462 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.462 | |
| 4ajg | F07 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.462 | |
| 1pj7 | FFO | Dimethylglycine oxidase | 1.5.3.10 | 0.461 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.461 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.461 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.461 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.461 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.461 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.461 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.461 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 1jf2 | CZH | Obelin | / | 0.460 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.460 | |
| 3g6z | A7T | Renin | 3.4.23.15 | 0.460 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.460 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.459 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.459 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.459 | |
| 2v5u | FMN | Flavodoxin | / | 0.459 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.459 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.459 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.459 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.458 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 1s36 | CEI | Obelin | / | 0.458 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.458 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 2bpo | FAD | NADPH--cytochrome P450 reductase | / | 0.458 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.458 | |
| 3htj | ET | EbrA repressor | / | 0.458 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.458 | |
| 3w2e | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.458 | |
| 4dya | 0MF | Nucleoprotein | / | 0.458 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.458 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.457 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.457 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 4bvh | AR6 | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.457 | |
| 1u70 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.456 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 2hzq | STR | Apolipoprotein D | / | 0.456 | |
| 2r7n | ADP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase | / | 0.456 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.456 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.456 | |
| 3k7m | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.456 | |
| 3r6i | JMS | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 3r94 | FLR | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 3rgz | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.456 | |
| 3vil | SA0 | Beta-glucosidase | / | 0.456 | |
| 4bvh | OCZ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.456 | |
| 4e2y | JHZ | Methyltransferase | / | 0.456 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.455 | |
| 1sqi | 869 | 4-hydroxyphenylpyruvate dioxygenase | / | 0.455 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.455 | |
| 2xys | SY9 | Soluble acetylcholine receptor | / | 0.455 | |
| 3hxf | BD9 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.455 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3oag | LPQ | Renin | 3.4.23.15 | 0.455 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.455 | |
| 4a7z | AY9 | Aldos-2-ulose dehydratase | / | 0.455 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.455 | |
| 4fh5 | UTP | Terminal uridylyltransferase cid1 | / | 0.455 | |
| 4i5x | FLF | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.455 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.455 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.455 | |
| 4phl | PIL | Phosphodiesterase | / | 0.455 | |
| 5ds3 | 09L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.455 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 1rpw | DID | HTH-type transcriptional regulator QacR | / | 0.454 | |
| 2yhu | WHF | Pteridine reductase | / | 0.454 | |
| 4dyb | 0MH | Nucleoprotein | / | 0.454 | |
| 4gtr | 7TR | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.454 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.454 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.453 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.453 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.453 | |
| 1zdw | FLV | Prenyltransferase | / | 0.453 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.453 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.453 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.453 | |
| 2fmn | 4HF | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.453 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.453 | |
| 2ipw | 2CL | Aldose reductase | 1.1.1.21 | 0.453 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.453 | |
| 2rcw | AAI | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.453 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.453 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.453 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
| 3vjc | ZGA | Squalene synthase | 2.5.1.21 | 0.453 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 4fvz | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.453 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 4hhy | 15R | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.453 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.453 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.453 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 1vp5 | NAP | Oxidoreductase, aldo/keto reductase family | / | 0.452 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.452 | |
| 2iej | S48 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.452 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 3cr7 | PPS | Adenylyl-sulfate kinase | 2.7.1.25 | 0.452 | |
| 3jq7 | DX2 | Pteridine reductase, putative | / | 0.452 | |
| 3l3l | L3L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.452 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 4br3 | U85 | Choline kinase alpha | 2.7.1.32 | 0.452 | |
| 1o1t | 2NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.451 | |
| 1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.451 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.451 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.451 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.451 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.451 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.451 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.451 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 3f90 | FMN | Flavodoxin | / | 0.451 | |
| 3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.451 | |
| 3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.451 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.451 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.451 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.451 | |
| 4gbr | CAU | Beta-2 adrenergic receptor | / | 0.451 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.450 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 2j7c | IDE | Beta-glucosidase A | 3.2.1.21 | 0.450 | |
| 2r1n | EPL | Phosphotriesterase | / | 0.450 | |
| 2r86 | ATP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase | / | 0.450 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.450 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.450 | |
| 3jq6 | DX1 | Pteridine reductase, putative | / | 0.450 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.450 | |
| 3qwh | KMP | 17beta-hydroxysteroid dehydrogenase | / | 0.450 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.450 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.449 | |
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 2cmf | F11 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.449 | |
| 2g27 | 4LG | Renin | 3.4.23.15 | 0.449 | |
| 2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.449 | |
| 2wgs | 1AZ | Glutamine synthetase | 6.3.1.2 | 0.449 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.449 | |
| 1e2l | TMC | Thymidine kinase | / | 0.448 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.448 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.448 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.448 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.448 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2idv | M7G | Eukaryotic translation initiation factor 4E-1 | / | 0.448 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.448 | |
| 2wnb | C5P | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | 2.4.99.4 | 0.448 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.448 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.448 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.448 | |
| 3r58 | NPS | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 4f79 | P53 | Putative phospho-beta-glucosidase | / | 0.448 | |
| 4kmz | FOL | Folate receptor beta | / | 0.448 | |
| 4uy6 | SAH | Histidine N-alpha-methyltransferase | / | 0.448 | |
| 4wlj | IK2 | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.448 | |
| 2y04 | 68H | Beta-1 adrenergic receptor | / | 0.448 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.447 | |
| 2gmv | UN8 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.447 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2o6h | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | 2.5.1.78 | 0.447 | |
| 2xnv | VU3 | Soluble acetylcholine receptor | / | 0.447 | |
| 3hgg | CHD | CmeR | / | 0.447 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.447 | |
| 4daj | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.447 | |
| 1amo | FMN | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1qv0 | CZH | Obelin | / | 0.446 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.446 | |
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 0.446 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2jgs | BTN | Avidin | / | 0.446 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.446 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.446 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.446 | |
| 3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4afe | GGY | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.446 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.446 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.446 | |
| 5a4w | QCT | Glutathione S-transferase F2 | 2.5.1.18 | 0.446 | |
| 5d0r | B1T | Adenylate cyclase type 10 | / | 0.446 | |
| 1fml | RTL | Retinol dehydratase | / | 0.445 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2e94 | 364 | Geranylgeranyl pyrophosphate synthase | / | 0.445 | |
| 2v0m | KLN | Cytochrome P450 3A4 | / | 0.445 | |
| 2vq7 | NAP | Putative flavin-containing monooxygenase | / | 0.445 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 3fvu | IAC | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.445 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.445 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.445 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.445 | |
| 3zj6 | VM2 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.445 | |
| 4dyp | 0MS | Nucleoprotein | / | 0.445 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.445 | |
| 4mrx | CZH | Obelin | / | 0.445 | |
| 4qfz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.445 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.444 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2a8g | GNG | Avidin | / | 0.444 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.444 | |
| 2jf6 | S55 | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.444 | |
| 2puc | GUN | HTH-type transcriptional repressor PurR | / | 0.444 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.444 | |
| 3dz6 | M8E | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.444 | |
| 3f6s | FMN | Flavodoxin | / | 0.444 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3gph | OID | Cytochrome P450 2E1 | 1.14.13 | 0.444 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.444 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.444 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.444 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.444 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.444 | |
| 4xcz | T3Q | Qdtf | / | 0.444 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.444 | |
| 1el4 | CTZ | Obelin | / | 0.443 | |
| 1zp4 | C2F | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.443 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.443 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.443 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3dla | NXX | Glutamine-dependent NAD(+) synthetase | 6.3.5.1 | 0.443 | |
| 3nhp | HGZ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.443 | |
| 3w5u | FAD | Ferredoxin | / | 0.443 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.443 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4c5o | FAD | Putative monooxygenase | / | 0.443 | |
| 4fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.443 | |
| 4fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.443 | |
| 4jq1 | NPS | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 4jt9 | 1NS | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.443 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.443 | |
| 4u15 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.443 | |
| 1c4v | IH2 | Prothrombin | 3.4.21.5 | 0.442 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.442 | |
| 1kyy | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.442 | |
| 2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.442 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.442 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 3bt9 | DEQ | HTH-type transcriptional regulator QacR | / | 0.442 | |
| 3c4h | DRL | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.442 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.442 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 3hii | PNT | Amiloride-sensitive amine oxidase [copper-containing] | / | 0.442 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.442 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.442 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.442 | |
| 4epq | 0RR | Poly(ADP-ribose) glycohydrolase | / | 0.442 | |
| 4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.441 | |
| 1qvt | PRL | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 2gl0 | ADN | Uncharacterized protein | / | 0.441 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 2po3 | T4K | 4-dehydrase | / | 0.441 | |
| 2vq3 | NAP | Metalloreductase STEAP3 | / | 0.441 | |
| 2vqq | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.441 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2y1x | 845 | Histone-arginine methyltransferase CARM1 | / | 0.441 | |
| 3b9g | IMH | IAG-nucleoside hydrolase | / | 0.441 | |
| 3cv7 | C2U | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.441 | |
| 3fu8 | 3DM | Laccase-1 | 1.10.3.2 | 0.441 | |
| 3gey | P34 | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.441 | |
| 3irh | DTP | HD domain protein | / | 0.441 | |
| 3jqg | AX6 | Pteridine reductase, putative | / | 0.441 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.441 | |
| 4hcy | 0YN | Transketolase | / | 0.441 | |
| 4imu | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 4xwt | U5P | Ribonuclease J | / | 0.441 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.441 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.440 | |
| 1m2x | MCO | Metallo-beta-lactamase type 2 | / | 0.440 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.440 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.440 | |
| 1vrq | FON | Subunit alpha of sarocosine oxidase | / | 0.440 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 2vz0 | D64 | Pteridine reductase | / | 0.440 | |
| 2yg5 | FAD | Putrescine oxidase | / | 0.440 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
| 3vhm | NPK | Avidin | / | 0.440 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.440 | |
| 4kn2 | LYA | Folate receptor beta | / | 0.440 | |
| 4rxr | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.440 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4xd1 | T3Q | Qdtf | / | 0.440 |