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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.11.000
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.539
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.507
4lfiGNPCasein kinase II subunit alpha2.7.11.10.488
4k2rANPTyrosine-protein kinase ZAP-702.7.10.20.482
3plsANPMacrophage-stimulating protein receptor2.7.10.10.480
3orpAGSSerine/threonine protein kinase/0.479
5dnrATPAurora kinase A2.7.11.10.474
4qnyANPMitogen activated protein kinase, putative/0.469
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.468
2yaaATPDeath-associated protein kinase 2/0.466
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.461
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.459
3gu7ADPDeath-associated protein kinase 12.7.11.10.456
4deeADPAurora kinase A2.7.11.10.455
1dawANPCasein kinase II subunit alpha2.7.11.10.454
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.454
5cnoANPEpidermal growth factor receptor2.7.10.10.453
5dosATPAurora kinase A2.7.11.10.453
1dayGNPCasein kinase II subunit alpha2.7.11.10.452
3c4wATPRhodopsin kinase/0.451
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.449
4fv6E57Mitogen-activated protein kinase 12.7.11.240.448
1qmzATPCyclin-dependent kinase 22.7.11.220.446
2qoqANPEphrin type-A receptor 32.7.10.10.446
2w4jADPDeath-associated protein kinase 12.7.11.10.446
1ig1ANPDeath-associated protein kinase 12.7.11.10.443
4lrjANPUncharacterized protein/0.443
1i44ACPInsulin receptor2.7.10.10.442
4qmlANPSerine/threonine-protein kinase 242.7.11.10.442
3qc9ADPRhodopsin kinase/0.441
4c3pACPAurora kinase A2.7.11.10.441
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.440
4s33ANPMitogen-activated protein kinase 12.7.11.240.440