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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3ou7SAMSAM-dependent methyltransferase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3ou7SAMSAM-dependent methyltransferase/1.000
3ou6SAMSAM-dependent methyltransferase/0.627
3ou2SAHSAM-dependent methyltransferase/0.529
4necSAHPutative SAM-dependent methyltransferase/0.480
3e23SAMUncharacterized protein/0.473
1x1bSAHC-20 methyltransferase/0.465
5je3SAHMethyl transferase/0.462
5jr3SAHCarminomycin 4-O-methyltransferase DnrK2.1.1.2920.460
1x1dSAHC-20 methyltransferase/0.456
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.456
1r00SAHAclacinomycin 10-hydroxylase RdmB4.1.10.452
4a6dSAMAcetylserotonin O-methyltransferase2.1.1.40.452
4qtuSAM18S rRNA (guanine(1575)-N(7))-methyltransferase/0.450
2gs9SAHUncharacterized protein/0.443
5e8jSAHmRNA cap guanine-N7 methyltransferase2.1.1.560.443
3ox4NADAlcohol dehydrogenase 21.1.1.10.441