sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 1.000 | |
| 4bf1 | 9FK | Carbonic anhydrase 2 | 4.2.1.1 | 0.722 | |
| 2eu3 | FF3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.715 | |
| 3dcw | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.715 | |
| 3dcc | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.713 | |
| 4mo8 | 2VQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.711 | |
| 2weh | FB1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.706 | |
| 4kni | E1E | Carbonic anhydrase 2 | 4.2.1.1 | 0.697 | |
| 2pow | I7C | Carbonic anhydrase 2 | 4.2.1.1 | 0.693 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.693 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.689 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.682 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.680 | |
| 1kwr | SG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.678 | |
| 1cny | EG3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.676 | |
| 3l14 | I7B | Carbonic anhydrase 2 | 4.2.1.1 | 0.675 | |
| 3m98 | E02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.674 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.673 | |
| 3mna | DWH | Carbonic anhydrase 2 | 4.2.1.1 | 0.673 | |
| 1g1d | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.671 | |
| 1g52 | F2B | Carbonic anhydrase 2 | 4.2.1.1 | 0.671 | |
| 4knj | E1F | Carbonic anhydrase 2 | 4.2.1.1 | 0.671 | |
| 3ffp | LC1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.669 | |
| 1if6 | FBU | Carbonic anhydrase 2 | 4.2.1.1 | 0.668 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.668 | |
| 2x7t | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.665 | |
| 3mmf | D9H | Carbonic anhydrase 2 | 4.2.1.1 | 0.664 | |
| 3m5e | JDR | Carbonic anhydrase 2 | 4.2.1.1 | 0.663 | |
| 3daz | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.662 | |
| 3p5l | IT5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.660 | |
| 3v2j | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.660 | |
| 3dd8 | 2C7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.659 | |
| 4ito | MPX | Carbonic anhydrase 2 | 4.2.1.1 | 0.657 | |
| 4itp | 1GD | Carbonic anhydrase 2 | 4.2.1.1 | 0.657 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.656 | |
| 3m2y | BE0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.654 | |
| 3mho | J43 | Carbonic anhydrase 2 | 4.2.1.1 | 0.653 | |
| 2weg | FBV | Carbonic anhydrase 2 | 4.2.1.1 | 0.651 | |
| 3sax | E50 | Carbonic anhydrase 2 | 4.2.1.1 | 0.651 | |
| 3m2n | J74 | Carbonic anhydrase 2 | 4.2.1.1 | 0.649 | |
| 3oy0 | OY0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.649 | |
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 | 0.648 | |
| 3s8x | E59 | Carbonic anhydrase 2 | 4.2.1.1 | 0.648 | |
| 3sbi | E90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.646 | |
| 1oq5 | CEL | Carbonic anhydrase 2 | 4.2.1.1 | 0.645 | |
| 3n0n | P9B | Carbonic anhydrase 2 | 4.2.1.1 | 0.645 | |
| 1okm | SAB | Carbonic anhydrase 2 | 4.2.1.1 | 0.643 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.643 | |
| 4ilx | 1EZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.643 | |
| 1cnw | EG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.642 | |
| 3oys | OYS | Carbonic anhydrase 2 | 4.2.1.1 | 0.642 | |
| 3d9z | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.639 | |
| 3n3j | WWV | Carbonic anhydrase 2 | 4.2.1.1 | 0.637 | |
| 4bf6 | X0Q | Carbonic anhydrase 2 | 4.2.1.1 | 0.637 | |
| 2wej | FB2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.636 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.635 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.634 | |
| 1eou | SMS | Carbonic anhydrase 2 | 4.2.1.1 | 0.634 | |
| 3mzc | S6I | Carbonic anhydrase 2 | 4.2.1.1 | 0.634 | |
| 1if4 | FBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.633 | |
| 3d8w | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.632 | |
| 3qyk | IE2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.630 | |
| 3bl1 | BL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.629 | |
| 4kap | 1QV | Carbonic anhydrase 2 | 4.2.1.1 | 0.629 | |
| 1g4j | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.628 | |
| 3n4b | WWZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.628 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.627 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.623 | |
| 3ml2 | SU0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.621 | |
| 3s9t | E49 | Carbonic anhydrase 2 | 4.2.1.1 | 0.620 | |
| 1bnv | AL7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.618 | |
| 1bnw | TPD | Carbonic anhydrase 2 | 4.2.1.1 | 0.618 | |
| 1bn1 | AL5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 1bn4 | AL9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 1i90 | INM | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 3oyq | OYQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.613 | |
| 1g45 | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.612 | |
| 3po6 | DT9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.612 | |
| 1a42 | BZU | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 1kwq | SG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 3bet | CTF | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.609 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.607 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 1bnt | AL2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.605 | |
| 3m96 | E38 | Carbonic anhydrase 2 | 4.2.1.1 | 0.604 | |
| 3myq | E27 | Carbonic anhydrase 2 | 4.2.1.1 | 0.604 | |
| 4iwz | 1GO | Carbonic anhydrase 2 | 4.2.1.1 | 0.604 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.603 | |
| 3igp | DT7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.602 | |
| 3sbh | E65 | Carbonic anhydrase 2 | 4.2.1.1 | 0.600 | |
| 1bnu | AL3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.596 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.595 | |
| 3nb5 | R21 | Carbonic anhydrase 2 | 4.2.1.1 | 0.594 | |
| 3hku | TOR | Carbonic anhydrase 2 | 4.2.1.1 | 0.593 | |
| 3mhi | J90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.593 | |
| 4m2r | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.592 | |
| 2weo | FBW | Carbonic anhydrase 2 | 4.2.1.1 | 0.589 | |
| 1i8z | INL | Carbonic anhydrase 2 | 4.2.1.1 | 0.587 | |
| 3mhc | ARZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.586 | |
| 1bnm | AL8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.582 | |
| 3m40 | J45 | Carbonic anhydrase 2 | 4.2.1.1 | 0.578 | |
| 1cil | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.577 | |
| 1okn | STB | Carbonic anhydrase 2 | 4.2.1.1 | 0.577 | |
| 2q1q | OSP | Carbonic anhydrase 2 | 4.2.1.1 | 0.575 | |
| 3t85 | SG7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.573 | |
| 3rz8 | RZ8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.572 | |
| 1cnx | EG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.571 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.568 | |
| 3f4x | KLT | Carbonic anhydrase 2 | 4.2.1.1 | 0.566 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.566 | |
| 1xpz | 4TZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.563 | |
| 2wd2 | MS5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.563 | |
| 3mhl | J71 | Carbonic anhydrase 2 | 4.2.1.1 | 0.563 | |
| 4pxx | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.561 | |
| 1yda | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.559 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.559 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.551 | |
| 4n16 | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.551 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.546 | |
| 2x7u | WZA | Carbonic anhydrase 2 | 4.2.1.1 | 0.544 | |
| 3n2p | AYX | Carbonic anhydrase 2 | 4.2.1.1 | 0.538 | |
| 1bnq | AL4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.536 | |
| 1if8 | SBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.531 | |
| 3t82 | SG4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.531 | |
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.525 | |
| 3t84 | SG6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.522 | |
| 5fl4 | 9FK | Carbonic anhydrase 9 | 4.2.1.1 | 0.522 | |
| 1if5 | FBT | Carbonic anhydrase 2 | 4.2.1.1 | 0.517 | |
| 4kp8 | E1G | Carbonic anhydrase 12 | 4.2.1.1 | 0.514 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.509 | |
| 3ni5 | C1H | Carbonic anhydrase 2 | 4.2.1.1 | 0.502 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.501 | |
| 3znc | BZ1 | Carbonic anhydrase 4 | 4.2.1.1 | 0.500 | |
| 4k0z | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.498 | |
| 1i9p | IOE | Carbonic anhydrase 2 | 4.2.1.1 | 0.493 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.493 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.493 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.491 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.490 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.490 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.485 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.484 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.484 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.484 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.484 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.483 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.481 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.481 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.480 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 1g4o | BSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.477 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.477 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.477 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.476 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.475 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.474 | |
| 2q3o | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.473 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.473 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.472 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.472 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.471 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.471 | |
| 3fw3 | ETS | Carbonic anhydrase 4 | 4.2.1.1 | 0.471 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.471 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.471 | |
| 4x5s | AZM | Carbonic anhydrase (Carbonate dehydratase) | / | 0.471 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.470 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.470 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.470 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.469 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.469 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.469 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.468 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.468 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.468 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.467 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.467 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.467 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.466 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.466 | |
| 1akb | PPD | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.465 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.465 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.465 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.465 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.465 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.464 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.464 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.464 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 4knn | E1F | Carbonic anhydrase 13 | 4.2.1.1 | 0.464 | |
| 4lu3 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.464 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.463 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.463 | |
| 2x91 | LPR | Angiotensin-converting enzyme | 3.4.15.1 | 0.463 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.463 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.463 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.463 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.462 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.462 | |
| 3v2u | ATP | Protein GAL3 | / | 0.462 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.462 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.462 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.461 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.461 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 4de2 | DN3 | Beta-lactamase | / | 0.461 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.460 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.460 | |
| 1b5e | DCM | Deoxycytidylate 5-hydroxymethyltransferase | 2.1.2.8 | 0.459 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.459 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.459 | |
| 3myt | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.459 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.459 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.459 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.458 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.458 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.458 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.458 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.458 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.458 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.457 | |
| 1s63 | 778 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.457 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.457 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.457 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.457 | |
| 4knm | E1E | Carbonic anhydrase 13 | 4.2.1.1 | 0.457 | |
| 4x7v | MIV | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.457 | |
| 4y1b | NAP | AntE | / | 0.457 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.457 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.456 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.456 | |
| 2uuo | LK3 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.456 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.456 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.456 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.455 | |
| 2qc8 | ADP | Glutamine synthetase | 6.3.1.2 | 0.455 | |
| 2xje | U5P | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.455 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.455 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.455 | |
| 3qvi | K95 | HAP protein | / | 0.455 | |
| 3vg1 | 0GT | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.455 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.455 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.454 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.454 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.454 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.454 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.454 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.454 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.454 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.453 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.453 | |
| 1l5s | 700 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.453 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.453 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 1sq5 | ADP | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 2i7n | ACO | Pantothenate kinase 1 | 2.7.1.33 | 0.453 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.453 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.452 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.452 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.452 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.452 | |
| 3qfr | FMN | NADPH--cytochrome P450 reductase | / | 0.452 | |
| 3qj0 | QI3 | Botulinum neurotoxin type A | 3.4.24.69 | 0.452 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.452 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.452 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.452 | |
| 4hu1 | V13 | Carbonic anhydrase 13 | 4.2.1.1 | 0.452 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.452 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1wxj | IPL | Tryptophan synthase alpha chain | / | 0.451 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.451 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.451 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.451 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.451 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.450 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.450 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.450 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.450 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.450 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.450 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.450 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.450 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 2b4d | COA | Diamine acetyltransferase 1 | / | 0.449 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.449 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.449 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.449 | |
| 4b64 | NAP | L-ornithine N(5)-monooxygenase | / | 0.449 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.449 | |
| 4usr | FAD | Monooxygenase | / | 0.449 | |
| 1g6o | ADP | Cag alpha | / | 0.448 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.448 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.448 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.448 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.448 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.448 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.448 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4dyp | 0MS | Nucleoprotein | / | 0.448 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.448 | |
| 4j7h | TRH | PCZA361.3 | / | 0.448 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.448 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.448 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.447 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.447 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.447 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.447 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.447 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.447 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.447 | |
| 4jxx | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.447 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.447 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.447 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.446 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.446 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.446 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.446 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.446 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.446 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4lut | DCS | Alanine racemase | / | 0.446 | |
| 4pzr | COA | Histone acetyltransferase p300 | / | 0.446 | |
| 5a01 | 12V | O-glycosyltransferase | / | 0.446 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.445 | |
| 1swt | BTN | Streptavidin | / | 0.445 | |
| 2wat | COA | Fatty acid synthase subunit alpha | 2.3.1.86 | 0.445 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.445 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.444 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.444 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.444 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.444 | |
| 2rd2 | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.444 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 3ksq | Z96 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.444 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4glx | 0XS | DNA ligase | 6.5.1.2 | 0.444 | |
| 4j7g | TRH | PCZA361.3 | / | 0.444 | |
| 5kgh | ACO | Predicted acetyltransferase | / | 0.444 | |
| 1kw8 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.443 | |
| 1o1s | 1NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 2d3a | ADP | Glutamine synthetase root isozyme 3 | 6.3.1.2 | 0.443 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.443 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.443 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.443 | |
| 3gf4 | UPG | UDP-galactopyranose mutase | 5.4.99.9 | 0.443 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.443 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.443 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 2bf4 | FAD | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.442 | |
| 3hdy | GDU | UDP-galactopyranose mutase | / | 0.442 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 4uov | AZM | Carbonate dehydratase | / | 0.442 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.441 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.441 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.441 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.441 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.441 | |
| 2r8v | ACO | Amino-acid acetyltransferase | / | 0.441 | |
| 2wqp | WQP | Polysialic acid capsule biosynthesis protein SiaC | / | 0.441 | |
| 2xfs | J01 | Uncharacterized protein | / | 0.441 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 3biy | 01K | Histone acetyltransferase p300 | / | 0.441 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.441 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 3h2s | NDP | Putative NADH-flavin reductase | / | 0.441 | |
| 3keq | NAD | Redox-sensing transcriptional repressor Rex | / | 0.441 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 3uk6 | ADP | RuvB-like 2 | 3.6.4.12 | 0.441 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.441 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.441 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.441 | |
| 1a5b | IGP | Tryptophan synthase alpha chain | / | 0.440 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.440 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.440 | |
| 1nl4 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.440 | |
| 1s20 | NAD | 2,3-diketo-L-gulonate reductase | 1.1.1.130 | 0.440 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.440 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.440 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.440 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.440 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.440 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.440 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.440 | |
| 4wdg | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.440 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.440 |