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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.91.000
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.882
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.819
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.735
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.729
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.698
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.682
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.632
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.628
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.627
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.619
1enyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.615
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.585
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.580
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.568
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.564
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.556
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.552
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.548
1enzNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.545
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.544
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.541
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.540
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.529
2ie0ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.527
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.523
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.516
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.495
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.492
3g5hYTTMycocyclosin synthase1.14.21.90.485
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.485
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.483
2b36NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.478
2y4gTIRTamL/0.476
3lvfNADGlyceraldehyde-3-phosphate dehydrogenase 1/0.476
2y3sTIRTamL/0.475
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.474
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.472
1rm4NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic1.2.1.130.470
2y3rTRKTamL/0.469
2vn0TDZCytochrome P450 2C8/0.464
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.464
4q72FADBifunctional protein PutA/0.461
2nq8ZIDEnoyl-ACP reductase/0.460
4q71FADBifunctional protein PutA/0.460
4qecNAPElxO/0.460
4wriOKAOkadaic acid binding protein 2-alpha/0.458
1t2cNAIL-lactate dehydrogenase1.1.1.270.457
2b35NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
4a81DXCMajor pollen allergen Bet v 1-A/0.457
4nbwNADShort-chain dehydrogenase/reductase SDR/0.457
4r20AERCytochrome P450 family 17 polypeptide 2/0.457
3zoiM2WIsopenicillin N synthase1.21.3.10.456
3gobHXXDdmC/0.455
3nr4PYVAbscisic acid receptor PYL2/0.455
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.453
3lqfNADGalactitol dehydrogenase/0.453
4ejmNAPPutative zinc-binding dehydrogenase/0.453
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.452
1xe65FPPlasmepsin-23.4.23.390.451
3hjaNADGlyceraldehyde-3-phosphate dehydrogenase/0.451
4ips1G4Mycocyclosin synthase1.14.21.90.451
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.451
4q73FADBifunctional protein PutA/0.451
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.450
3gw9VNILanosterol 14-alpha-demethylase/0.450
4enhFVXCholesterol 24-hydroxylase/0.450
4esoNAPPutative oxidoreductase/0.450
4p8rNADGlyceraldehyde-3-phosphate dehydrogenase/0.449
1nptNADGlyceraldehyde-3-phosphate dehydrogenase/0.448
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.447
2jn3JN3Fatty acid-binding protein, liver/0.447
3a1nNADNDP-sugar epimerase/0.447
1m9m6NINitric oxide synthase, endothelial1.14.13.390.446
3nxxNDPDihydrofolate reductase1.5.1.30.446
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.446
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.445
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4ipw1G7Mycocyclosin synthase1.14.21.90.445
1hb1OCVIsopenicillin N synthase1.21.3.10.444
2jb4A14Isopenicillin N synthase1.21.3.10.444
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.444
2zbaZBATrichothecene 3-O-acetyltransferase/0.444
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
1ee9NADMethylenetetrahydrofolate dehydrogenase [NAD(+)]1.5.1.150.443
2bd0NAPSepiapterin reductase/0.443
1ia4TQ6Dihydrofolate reductase1.5.1.30.442
1r2jFADFkbI/0.442
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
3qlsNDPDihydrofolate reductase1.5.1.30.442
4e5yNDPGDP-L-fucose synthase1.1.1.2710.442
4o59NADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.442
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.441
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.441
1jg0DDTThymidylate synthase/0.441
2he5NDPAldo-keto reductase family 1 member C211.1.10.441
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.441
3idsNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.441
3vt65YIVitamin D3 receptor/0.441
4ia3BIVVitamin D3 receptor A/0.441
4jx1CAHCamphor 5-monooxygenase1.14.15.10.441
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1jioDEB6-deoxyerythronolide B hydroxylase/0.440
1oc1ASVIsopenicillin N synthase1.21.3.10.440
2ejvNADL-threonine 3-dehydrogenase/0.440
2vbdV10Isopenicillin N synthase1.21.3.10.440
4g48PZBMycocyclosin synthase1.14.21.90.440
5hs1VORLanosterol 14-alpha demethylase/0.440