Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3oct1N1Tyrosine-protein kinase BTK2.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3oct1N1Tyrosine-protein kinase BTK2.7.10.21.000
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.537
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.535
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.517
1bygSTUTyrosine-protein kinase CSK/0.513
3qri919Tyrosine-protein kinase ABL12.7.10.20.495
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.494
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.490
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.489
2vwx7X4Ephrin type-B receptor 42.7.10.10.489
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.484
2of4979Tyrosine-protein kinase Lck2.7.10.20.482
2of2547Tyrosine-protein kinase Lck2.7.10.20.479
4bb432WEphrin type-B receptor 42.7.10.10.479
1jpaANPEphrin type-B receptor 22.7.10.10.478
2hziJINTyrosine-protein kinase ABL12.7.10.20.478
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.477
1blzACVIsopenicillin N synthase1.21.3.10.476
4g2fC07Ephrin type-A receptor 32.7.10.10.476
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.475
3ac2KSETyrosine-protein kinase Lck2.7.10.20.474
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.473
2ofv242Tyrosine-protein kinase Lck2.7.10.20.473
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.472
4gk4L90Ephrin type-A receptor 32.7.10.10.472
2vwz7X6Ephrin type-B receptor 42.7.10.10.470
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.469
2f4jVX6Tyrosine-protein kinase ABL12.7.10.20.468
4af3VX6Aurora kinase B2.7.11.10.468
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.467
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.466
2qoqANPEphrin type-A receptor 32.7.10.10.466
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.466
3nx4NAPPutative oxidoreductase/0.466
5k2bZMAAdenosine receptor A2a/0.466
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.465
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.465
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.465
1f4gTP4Thymidylate synthase/0.464
3g0fB49Mast/stem cell growth factor receptor Kit2.7.10.10.464
4riyADPEpidermal growth factor receptor2.7.10.10.464
2y6o1N1Ephrin type-A receptor 42.7.10.10.463
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.463
2qo9ANPEphrin type-A receptor 32.7.10.10.462
1kzjCB3Thymidylate synthase/0.461
2xyuQ9GEphrin type-A receptor 42.7.10.10.461
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.461
1m17AQ4Epidermal growth factor receptor2.7.10.10.460
1n83CLRNuclear receptor ROR-alpha/0.460
2xynVX6Abelson tyrosine-protein kinase 22.7.10.20.460
3ac1KZITyrosine-protein kinase Lck2.7.10.20.460
2vwy7X5Ephrin type-B receptor 42.7.10.10.459
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.459
3el7PD3Proto-oncogene tyrosine-protein kinase Src2.7.10.20.457
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.457
4jqh1MFAlr2278 protein/0.457
5k2cZMAAdenosine receptor A2a/0.457
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.456
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.456
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.456
1m52P17Tyrosine-protein kinase ABL12.7.10.20.455
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.455
3ds6A17Mitogen-activated protein kinase 14/0.455
3zkyWT4Isopenicillin N synthase1.21.3.10.455
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.455
1uzwCDHIsopenicillin N synthase1.21.3.10.454
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.454
2ittAEEEpidermal growth factor receptor2.7.10.10.453
3fl8RARDihydrofolate reductase/0.453
2c0cNAPProstaglandin reductase 310.452
2d4vNADIsocitrate dehydrogenase [NADP]/0.452
2vx17X8Ephrin type-B receptor 42.7.10.10.452
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.452
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.452
4bb3KKAIsopenicillin N synthase1.21.3.10.452
4j6bPLOCytochrome P450 monooxygenase/0.452
4tyj0LIFibroblast growth factor receptor 42.7.10.10.452
1f123HCHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.451
1f4fTP3Thymidylate synthase/0.451
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
2hk51BMTyrosine-protein kinase HCK2.7.10.20.451
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.450
2fzwNADAlcohol dehydrogenase class-31.1.1.10.450
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.450
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.450
4id71G0Activated CDC42 kinase 1/0.450
1w06W05Isopenicillin N synthase1.21.3.10.449
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.449
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.449
3a1nNADNDP-sugar epimerase/0.449
3e5aVX6Aurora kinase A2.7.11.10.449
4fnyI3KALK tyrosine kinase receptor2.7.10.10.449
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.449
1ppjANYCytochrome b/0.448
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
2xvdAS6Ephrin type-B receptor 42.7.10.10.448
3tvuB37Acetyl-CoA carboxylase/0.448
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.448
1oc1ASVIsopenicillin N synthase1.21.3.10.447
2itvANPEpidermal growth factor receptor2.7.10.10.447
2vx07X7Ephrin type-B receptor 42.7.10.10.447
2y6fM9FIsopenicillin N synthase1.21.3.10.447
3tdaPN0Cytochrome P450 2D6/0.447
4c58824Cyclin-G-associated kinase2.7.11.10.447
4cnjFADL-amino acid oxidase/0.447
4ez8DHFThymidylate synthase2.1.1.450.447
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.446
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.446
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.446
3qm4PN0Cytochrome P450 2D6/0.446
3vo30KFVascular endothelial growth factor receptor 22.7.10.10.446
4fehFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.446
4jlk1NODeoxycytidine kinase2.7.1.740.446
4l8u9AZSerum albumin/0.446
1y0s331Peroxisome proliferator-activated receptor delta/0.445
2ftoCB3Thymidylate synthase/0.445
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.445
3bgxMEFThymidylate synthase/0.445
4qe6JN3Bile acid receptor/0.445
1ra3NAPDihydrofolate reductase1.5.1.30.444
1zdwFLVPrenyltransferase/0.444
2gs7ANPEpidermal growth factor receptor2.7.10.10.444
2x9fX9FEphrin type-B receptor 42.7.10.10.444
3stxBKAMethylketone synthase I/0.444
3tqhNDPQuinone oxidoreductase/0.444
3zuxTCHTransporter/0.444
4jbtASDCytochrome P450 monooxygenase/0.444
4o701QKBromodomain-containing protein 4/0.444
5dp2NAPCurF/0.444
1bk0ACVIsopenicillin N synthase1.21.3.10.443
1fwmCB3Thymidylate synthase/0.443
2wouZZFTGF-beta receptor type-12.7.11.300.443
3wmxNADNAD dependent epimerase/dehydratase/0.443
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.443
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.443
4jq8KJ8Epidermal growth factor receptor2.7.10.10.443
1t0lNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.442
2bu9HFVIsopenicillin N synthase1.21.3.10.442
2itnANPEpidermal growth factor receptor2.7.10.10.442
2j3kNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.442
2vcmM11Isopenicillin N synthase1.21.3.10.442
2wotZZGTGF-beta receptor type-12.7.11.300.442
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.442
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.442
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.442
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
4i22IREEpidermal growth factor receptor2.7.10.10.442
4irnFADAnaB/0.442
4jayFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.442
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.442
5emhNAPIridoid synthase1.3.1.990.442
1s7gNADNAD-dependent protein deacylase 2/0.441
1tehNADAlcohol dehydrogenase class-31.1.1.10.441
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.441
2po7CHDFerrochelatase, mitochondrial4.99.1.10.441
2w2lNADD-mandelate dehydrogenase/0.441
3l0lHC3Nuclear receptor ROR-gamma/0.441
3vjoANPEpidermal growth factor receptor2.7.10.10.441
3vryB43Tyrosine-protein kinase HCK2.7.10.20.441
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.441
4fewPP2Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.441
4iaq2GM5-hydroxytryptamine receptor 1B/0.441
4ly91YYGlucokinase regulatory protein/0.441
4mihFADPyranose 2-oxidase1.1.3.100.441
4wkqIREEpidermal growth factor receptor2.7.10.10.441
5br4NADLactaldehyde reductase1.1.1.770.441
2b9yFADPutative aminooxidase/0.440
2c3qGTXGlutathione S-transferase theta-12.5.1.180.440
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.440
2qu5276Vascular endothelial growth factor receptor 22.7.10.10.440
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3eteNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.440
4g3jVNTLanosterol 14-alpha-demethylase/0.440
4hvs647Mast/stem cell growth factor receptor Kit2.7.10.10.440
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.440
5jtbZMAAdenosine receptor A2a/0.440