sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3o0q | ADN | Vitamin B12-dependent ribonucleotide reductase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3o0q | ADN | Vitamin B12-dependent ribonucleotide reductase | / | 1.000 | |
| 3o0o | 5AD | Vitamin B12-dependent ribonucleotide reductase | / | 0.630 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.512 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.504 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.501 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.497 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.494 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.494 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.493 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.492 | |
| 1kp3 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.490 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.490 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.489 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.488 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.487 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.486 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.486 | |
| 3rfa | SAM | Dual-specificity RNA methyltransferase RlmN | / | 0.485 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.484 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.483 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.483 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.482 | |
| 4u0m | ATP | Cyclic GMP-AMP synthase | / | 0.482 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.481 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.481 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.480 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.479 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.479 | |
| 1cdo | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.478 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.478 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.478 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.478 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.475 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.474 | |
| 3nd6 | ATP | Phosphopantetheine adenylyltransferase | / | 0.474 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.474 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.473 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.473 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.471 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.471 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.471 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.471 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.471 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.471 | |
| 2dgn | DOI | Adenylosuccinate synthetase isozyme 1 | / | 0.470 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.470 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.470 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.470 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.470 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.469 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.469 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.469 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.469 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.469 | |
| 3ik6 | HCZ | Glutamate receptor 2 | / | 0.469 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.469 | |
| 5af7 | FAD | Acyl-CoA dehydrogenase | / | 0.469 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.468 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.468 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.468 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.466 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.466 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.466 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.466 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.466 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.465 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.465 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.465 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.465 | |
| 3c21 | 2BA | DNA integrity scanning protein DisA | / | 0.465 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.465 | |
| 3h6v | NS6 | Glutamate receptor 2 | / | 0.465 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.465 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.464 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.464 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.464 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.464 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.463 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.463 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.463 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.463 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.463 | |
| 3ivx | FG6 | Pantothenate synthetase | 6.3.2.1 | 0.463 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.463 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.463 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.462 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.462 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.462 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.461 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.461 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.461 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.461 | |
| 3ieu | GDP | GTPase Era | / | 0.461 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.461 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 3ms4 | 21N | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.461 | |
| 3nbv | ANP | Ketohexokinase | / | 0.461 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.461 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.461 | |
| 5eb5 | FAD | (R)-mandelonitrile lyase 1 | 4.1.2.10 | 0.461 | |
| 1n2i | PAJ | Pantothenate synthetase | 6.3.2.1 | 0.460 | |
| 1t2a | NDP | GDP-mannose 4,6 dehydratase | 4.2.1.47 | 0.460 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.460 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.459 | |
| 2ejz | SAH | Diphthine synthase | / | 0.459 | |
| 4f5y | C2E | Stimulator of interferon genes protein | / | 0.459 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.459 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.458 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.458 | |
| 3tdj | 3TJ | Glutamate receptor 2 | / | 0.458 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.458 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.458 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.457 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.457 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.457 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.457 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.457 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.457 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.457 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.457 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.457 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.457 | |
| 4emt | C2E | Stimulator of interferon genes protein | / | 0.457 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.457 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.457 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.456 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1k7f | IAV | Tryptophan synthase alpha chain | / | 0.456 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.456 | |
| 2ex1 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.456 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.456 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.456 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.456 | |
| 4yxm | 2BA | DNA integrity scanning protein DisA | / | 0.456 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.455 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.455 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.455 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.455 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.455 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.455 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.455 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.455 | |
| 3lsm | SFD | Pyranose 2-oxidase | / | 0.455 | |
| 4f9g | C2E | Stimulator of interferon genes protein | / | 0.455 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.455 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.455 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.455 | |
| 4px9 | ADP | ATP-dependent RNA helicase DDX3X | 3.6.4.13 | 0.455 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.455 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.454 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.454 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.454 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.454 | |
| 3dm6 | 757 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.454 | |
| 3itj | FAD | Thioredoxin reductase 1 | 1.8.1.9 | 0.454 | |
| 3up5 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.454 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.454 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.454 | |
| 1jil | 485 | Tyrosine--tRNA ligase | / | 0.453 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.453 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.453 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.453 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.453 | |
| 3cow | 52H | Pantothenate synthetase | 6.3.2.1 | 0.453 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.453 | |
| 4blr | UTP | NTPase P4 | / | 0.453 | |
| 4bls | APC | NTPase P4 | / | 0.453 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.452 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.452 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.452 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.452 | |
| 2a87 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.452 | |
| 2hqm | FAD | Glutathione reductase | 1.8.1.7 | 0.452 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.452 | |
| 3a3g | DLZ | Lumazine protein | / | 0.452 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.452 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.451 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.451 | |
| 2eeq | SAH | Diphthine synthase | / | 0.451 | |
| 2irz | I02 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.451 | |
| 2ph6 | 712 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.451 | |
| 3ivg | FG5 | Pantothenate synthetase | 6.3.2.1 | 0.451 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.451 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.451 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.451 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.451 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.451 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.451 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.450 | |
| 1ur5 | NAD | Malate dehydrogenase | / | 0.450 | |
| 2b8v | 3BN | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 2ntr | L00 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 2vou | FAD | 2,6-dihydroxypyridine 3-monooxygenase | 1.14.13.10 | 0.450 | |
| 3cin | NAD | Myo-inositol-1-phosphate synthase-related protein | / | 0.450 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.450 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.450 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.450 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.450 | |
| 1yqd | NAP | Sinapyl alcohol dehydrogenase | / | 0.449 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.449 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.449 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 2qrq | S13 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.449 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.449 | |
| 3eks | CY9 | Actin-5C | / | 0.449 | |
| 3vg1 | 0GT | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.449 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.449 | |
| 4y3j | HIC | Endothiapepsin | 3.4.23.22 | 0.449 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.448 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.448 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.448 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.448 | |
| 2xy3 | DUP | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.448 | |
| 2z4y | 252 | Geranylgeranyl pyrophosphate synthase | / | 0.448 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.448 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.448 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 3fpz | AHZ | Thiamine thiazole synthase | / | 0.448 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.448 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.448 | |
| 4mcb | 21W | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.448 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.448 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.447 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.447 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.447 | |
| 1yre | COA | Uncharacterized protein | / | 0.447 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.447 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.447 | |
| 2emu | SAH | Diphthine synthase | / | 0.447 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.447 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.447 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.447 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.447 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.447 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.447 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.447 | |
| 1q12 | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.446 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.446 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.446 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.446 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.446 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3fql | 79Z | Genome polyprotein | 2.7.7.48 | 0.446 | |
| 3ljt | LA3 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.446 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.446 | |
| 3r95 | ACO | MccE protein | / | 0.446 | |
| 3ukf | GDU | UDP-galactopyranose mutase | / | 0.446 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.446 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.446 | |
| 5a1t | NAI | L-lactate dehydrogenase | / | 0.446 | |
| 5dp2 | NAP | CurF | / | 0.446 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.445 | |
| 2eud | GCQ | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.445 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.445 | |
| 2p6k | SAH | Diphthine synthase | / | 0.445 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.445 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.445 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.445 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.445 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.445 | |
| 4j75 | TYM | Tryptophan--tRNA ligase | / | 0.445 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.445 | |
| 1o97 | FAD | Electron transfer flavoprotein subunit alpha | / | 0.444 | |
| 1p0f | NAP | NADP-dependent alcohol dehydrogenase | 1.1.1.2 | 0.444 | |
| 1p4a | PCP | Pur operon repressor | / | 0.444 | |
| 1qf4 | RPD | Adenylosuccinate synthetase | / | 0.444 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.444 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.444 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.444 | |
| 2qs1 | UB1 | Glutamate receptor ionotropic, kainate 1 | / | 0.444 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.444 | |
| 2y3s | TIR | TamL | / | 0.444 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.444 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.444 | |
| 3int | FDA | UDP-galactopyranose mutase | 5.4.99.9 | 0.444 | |
| 3pvt | 3HC | 1,2-phenylacetyl-CoA epoxidase, subunit A | 1.14.13.149 | 0.444 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.444 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.444 | |
| 3x2e | NAI | Adenosylhomocysteinase | / | 0.444 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 4im0 | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.444 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.444 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.444 | |
| 4udr | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.444 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.443 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.443 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2cns | ACO | Ribosomal-protein-alanine acetyltransferase | / | 0.443 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.443 | |
| 2y4g | TIR | TamL | / | 0.443 | |
| 2yy8 | SAM | tRNA (cytidine(56)-2'-O)-methyltransferase | / | 0.443 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.443 | |
| 3etg | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.443 | |
| 3ilt | TRU | Glutamate receptor 2 | / | 0.443 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
| 3mk6 | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.443 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.443 | |
| 3rba | COD | Phosphopantetheine adenylyltransferase | / | 0.443 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.443 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.443 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.443 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.443 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.442 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.442 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.442 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.442 | |
| 2xfi | XFI | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.442 | |
| 3cz7 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.442 | |
| 3fst | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.442 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.442 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.442 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.442 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.442 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.442 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.442 | |
| 4dpf | 0LG | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.442 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.442 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1gc5 | ADP | ADP-dependent glucokinase | 2.7.1.147 | 0.441 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.441 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.441 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.441 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.441 | |
| 3ime | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.441 | |
| 3r96 | ACO | MccE protein | / | 0.441 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.441 | |
| 4irn | FAD | AnaB | / | 0.441 | |
| 4qxp | 1YE | Stimulator of interferon genes protein | / | 0.441 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.440 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.440 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.440 | |
| 1sdw | IYT | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.440 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.440 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.440 | |
| 2bf4 | FMN | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.440 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.440 | |
| 2is0 | I03 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.440 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.440 | |
| 3s2v | 3HU | Glutamate receptor ionotropic, kainate 1 | / | 0.440 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.440 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4cpd | NAD | Alcohol dehydrogenase | / | 0.440 | |
| 4eua | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.440 | |
| 4fse | 0VA | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.440 | |
| 4j4n | D44 | Peptidylprolyl isomerase | / | 0.440 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.440 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.440 |