scPDB - Distribution of Binding site Similarity values of 3nxv entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3nxv	D2F	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	1.000
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	0.731
3nxy	D2H	Dihydrofolate reductase	1.5.1.3	0.658
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.630
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.606
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.592
3nxo	D2B	Dihydrofolate reductase	1.5.1.3	0.585
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.584
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.582
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.581
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.567
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.549
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.538
4qjc	IXE	Dihydrofolate reductase	1.5.1.3	0.530
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.520
1s3w	TQT	Dihydrofolate reductase	1.5.1.3	0.519
1dlr	MXA	Dihydrofolate reductase	1.5.1.3	0.510
1dr4	HBI	Dihydrofolate reductase	1.5.1.3	0.508
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.504
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.500
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.500
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.495
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.488
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.488
4ddr	MMV	Dihydrofolate reductase	1.5.1.3	0.482
3cse	N22	Uncharacterized protein	/	0.480
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.480
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.475
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.475
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.473
3eek	53S	Uncharacterized protein	/	0.473
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.473
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.472
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.470
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.466
4h98	14Q	Uncharacterized protein	/	0.462
3eem	53V	Uncharacterized protein	/	0.461
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.460
3qly	55V	Uncharacterized protein	/	0.460
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.459
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.457
3qlx	QLR	Uncharacterized protein	/	0.456
3sn7	540	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.456
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.455
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.454
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.454
3p3z	P3Z	Putative cytochrome P450	/	0.454
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.454
3eej	53R	Uncharacterized protein	/	0.453
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.452
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.451
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.449
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.449
3njo	PYV	Abscisic acid receptor PYR1	/	0.448
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.448
3qlz	QLZ	Uncharacterized protein	/	0.446
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.444
3sni	546	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.443
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.442
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.441
3g70	A5T	Renin	3.4.23.15	0.441
2y46	MIV	Mycinamicin IV hydroxylase/epoxidase	/	0.440