scPDB - Distribution of Binding site Similarity values of 3nxr entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3nxr	D2D	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	1.000
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.785
3nxy	D2H	Dihydrofolate reductase	1.5.1.3	0.663
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.647
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.615
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.607
3nxo	D2B	Dihydrofolate reductase	1.5.1.3	0.603
1s3w	TQT	Dihydrofolate reductase	1.5.1.3	0.594
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.594
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.590
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.582
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.581
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.581
4ddr	MMV	Dihydrofolate reductase	1.5.1.3	0.574
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.562
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.548
1dlr	MXA	Dihydrofolate reductase	1.5.1.3	0.540
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.539
4qjc	IXE	Dihydrofolate reductase	1.5.1.3	0.539
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.524
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.519
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.518
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.518
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.506
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.504
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.502
1dr4	HBI	Dihydrofolate reductase	1.5.1.3	0.500
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.495
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.492
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.488
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.486
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.484
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.484
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.483
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.482
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.481
3cse	N22	Uncharacterized protein	/	0.478
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.478
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.478
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.475
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.474
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.472
3qlx	QLR	Uncharacterized protein	/	0.472
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.467
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.465
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.463
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.462
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.461
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.461
3njo	PYV	Abscisic acid receptor PYR1	/	0.461
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.460
3qly	55V	Uncharacterized protein	/	0.459
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.457
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.456
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.455
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.455
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.455
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.454
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.454
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.453
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.453
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.453
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.451
3nu0	3TU	Dihydrofolate reductase	1.5.1.3	0.451
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.451
1yho	TRR	Dihydrofolate reductase	1.5.1.3	0.450
3sni	546	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.450
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.450
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.448
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.448
4h98	14Q	Uncharacterized protein	/	0.448
3eem	53V	Uncharacterized protein	/	0.447
4gkh	0J9	Aminoglycoside 3'-phosphotransferase AphA1-IAB	/	0.447
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.446
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.446
1xi2	CB1	Ribosyldihydronicotinamide dehydrogenase [quinone]	/	0.445
3eek	53S	Uncharacterized protein	/	0.445
3nfr	EWQ	Ribosyldihydronicotinamide dehydrogenase [quinone]	/	0.445
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.444
3c3d	FO1	2-phospho-L-lactate transferase	/	0.444
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.443
3oad	LPO	Renin	3.4.23.15	0.443
3sn7	540	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.443
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.443
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.443
3dyn	PCG	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.441
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.441
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.441
2aou	CQA	Histamine N-methyltransferase	2.1.1.8	0.440
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.440
3p3z	P3Z	Putative cytochrome P450	/	0.440
3um8	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.440