Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
3n8z | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 |
PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
---|---|---|---|---|---|
3n8z | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 1.000 | |
1eqh | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.663 | |
3n8w | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.657 | |
1eqg | IBP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.653 | |
1ht8 | 34C | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.649 | |
2ayl | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.636 | |
3pgh | FLP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.635 | |
1q4g | BFL | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.628 | |
3rr3 | FLR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.624 | |
4fm5 | DF0 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.615 | |
3n8x | NIM | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.595 | |
4cox | IMN | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.587 | |
2oyu | IMS | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.586 | |
3ntg | D72 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.583 | |
2oye | IM8 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.581 | |
3ln1 | CEL | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.578 | |
4ph9 | IBP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.578 | |
5ikr | ID8 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.577 | |
3q7d | NPX | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.575 | |
3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.559 | |
3kk6 | CEL | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.554 | |
4rrx | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.543 | |
6cox | S58 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.540 | |
4oty | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.526 | |
4rrw | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.514 | |
4rrz | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.514 | |
1efv | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.493 | |
1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.493 | |
4qe6 | JN3 | Bile acid receptor | / | 0.493 | |
2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
3aba | FLI | Cytochrome P450 | / | 0.489 | |
3zcw | 4A2 | Kinesin-like protein KIF11 | / | 0.487 | |
2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.486 | |
2ghm | LIC | Mitogen-activated protein kinase 14 | / | 0.485 | |
4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.485 | |
4xey | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.481 | |
3qly | 55V | Uncharacterized protein | / | 0.480 | |
5ikt | TLF | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.480 | |
1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
1juj | LYA | Thymidylate synthase | 2.1.1.45 | 0.477 | |
2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
2hfp | NSI | Peroxisome proliferator-activated receptor gamma | / | 0.477 | |
2bxi | AZQ | Serum albumin | / | 0.476 | |
4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.476 | |
2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.475 | |
3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
3kpz | ZNE | Vitamin D3 receptor | / | 0.475 | |
3lu7 | IPX | Serum albumin | / | 0.475 | |
1wlv | COA | Phenylacetic acid degradation protein PaaI | / | 0.474 | |
4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
3ln0 | 52B | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.473 | |
1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
1ju6 | LYA | Thymidylate synthase | 2.1.1.45 | 0.471 | |
3ia4 | MTX | Dihydrofolate reductase | / | 0.471 | |
3w5t | LHP | Vitamin D3 receptor | / | 0.471 | |
4oav | ACP | 2-5A-dependent ribonuclease | 3.1.26 | 0.471 | |
2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.470 | |
3eel | 53T | Uncharacterized protein | / | 0.470 | |
3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.470 | |
3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
4c4h | 7RO | Dual specificity protein kinase TTK | 2.7.12.1 | 0.470 | |
4eny | J19 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.470 | |
1cqp | 803 | Integrin alpha-L | / | 0.469 | |
3p7n | FMN | Light-activated DNA-binding protein EL222 | / | 0.469 | |
3spt | UD1 | Bifunctional protein GlmU | / | 0.468 | |
3zy5 | GFB | GDP-fucose protein O-fucosyltransferase 1 | 2.4.1.221 | 0.468 | |
4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.468 | |
1qvn | FRI | Interleukin-2 | / | 0.467 | |
1qzf | CB3 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.467 | |
3cwk | REA | Cellular retinoic acid-binding protein 2 | / | 0.467 | |
3eej | 53R | Uncharacterized protein | / | 0.467 | |
3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.467 | |
4fa6 | 0TA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.467 | |
2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.466 | |
3ttj | JBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.466 | |
3zok | NAD | 3-dehydroquinate synthase, chloroplastic | 4.2.3.4 | 0.466 | |
4fhh | 0U3 | Vitamin D3 receptor A | / | 0.466 | |
1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.465 | |
2cbs | R13 | Cellular retinoic acid-binding protein 2 | / | 0.465 | |
2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.465 | |
2zlc | VDX | Vitamin D3 receptor | / | 0.465 | |
3eek | 53S | Uncharacterized protein | / | 0.465 | |
3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
3wow | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.465 | |
4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.465 | |
4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.465 | |
2zza | FOL | Dihydrofolate reductase | / | 0.464 | |
4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
4o0u | ADN | Aurora kinase A | 2.7.11.1 | 0.464 | |
4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
1ie4 | T44 | Transthyretin | / | 0.463 | |
1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
1rkg | VD1 | Vitamin D3 receptor | / | 0.463 | |
2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.463 | |
2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.463 | |
4a2b | AGS | Cell division protein FtsA | / | 0.463 | |
4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.463 | |
4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.463 | |
1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
1ysx | 4EB | Serum albumin | / | 0.462 | |
2o0u | C0M | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.462 | |
4fhi | 0S4 | Vitamin D3 receptor A | / | 0.462 | |
1iyz | NDP | Probable quinone oxidoreductase | / | 0.461 | |
1om1 | IQA | Casein kinase II subunit alpha | 2.7.11.1 | 0.461 | |
1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
3d8v | UD1 | Bifunctional protein GlmU | / | 0.461 | |
3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.461 | |
3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.461 | |
3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.461 | |
3vt5 | YI2 | Vitamin D3 receptor | / | 0.461 | |
4b4d | FAD | Ferredoxin-NADP reductase | / | 0.461 | |
4bbe | 3O4 | Tyrosine-protein kinase JAK2 | / | 0.461 | |
4dea | NHI | Aurora kinase A | 2.7.11.1 | 0.461 | |
1sn0 | T44 | Transthyretin | / | 0.460 | |
3tdk | UPG | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.460 | |
4wxl | BB2 | Peptide deformylase | / | 0.460 | |
1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
1kij | NOV | DNA gyrase subunit B | / | 0.459 | |
1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
1sn5 | T3 | Transthyretin | / | 0.459 | |
3frq | ERY | Erythromycin resistance repressor protein | / | 0.459 | |
3q92 | XNB | Ketohexokinase | / | 0.459 | |
3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
4otp | ADP | Serine/threonine-protein kinase RIO1 | 2.7.11.1 | 0.459 | |
4uux | APR | CinA-like protein | / | 0.459 | |
1yhs | STU | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.458 | |
2aib | ERG | Beta-elicitin cinnamomin | / | 0.458 | |
2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.458 | |
2wes | FAD | Tryptophan 5-halogenase | / | 0.458 | |
4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
4iah | 1DX | Alr2278 protein | / | 0.458 | |
4j6d | TES | Cytochrome P450 monooxygenase | / | 0.458 | |
1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.457 | |
1rd4 | L08 | Integrin alpha-L | / | 0.457 | |
1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.457 | |
1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.457 | |
2rgx | AP5 | Adenylate kinase | / | 0.457 | |
2wsa | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
3pre | 3RE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
4oau | ADP | 2-5A-dependent ribonuclease | 3.1.26 | 0.457 | |
1ie8 | KH1 | Vitamin D3 receptor | / | 0.456 | |
1kqw | RTL | Cellular retinol-binding protein type II | / | 0.456 | |
1x8v | ESL | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.456 | |
2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
2vw5 | BC6 | ATP-dependent molecular chaperone HSP82 | / | 0.456 | |
3f0a | ACO | Spermidine N(1)-acetyltransferase | / | 0.456 | |
3ncg | BK1 | Calmodulin-domain protein kinase 1, putative | / | 0.456 | |
3tgu | WF3 | Cytochrome b | / | 0.456 | |
3w2w | ATP | CRISPR system Cmr subunit Cmr2 | / | 0.456 | |
4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.456 | |
4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
4j6c | STR | Cytochrome P450 monooxygenase | / | 0.456 | |
1efp | FAD | Electron transfer flavoprotein subunit alpha | / | 0.455 | |
1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.455 | |
1sqq | OST | Cytochrome b | / | 0.455 | |
2v1a | FMN | NPH1-1 | / | 0.455 | |
2v1x | ADP | ATP-dependent DNA helicase Q1 | 3.6.4.12 | 0.455 | |
2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.455 | |
4itf | TFY | Vitamin D3 receptor | / | 0.455 | |
4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
4nr4 | 2LK | CREB-binding protein | / | 0.455 | |
4uz6 | SCR | Palmitoleoyl-protein carboxylesterase NOTUM | / | 0.455 | |
1n4h | REA | Nuclear receptor ROR-beta | / | 0.454 | |
1pxx | DIF | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.454 | |
1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.454 | |
1x7j | GEN | Estrogen receptor beta | / | 0.454 | |
2a1u | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.454 | |
2dfd | NAD | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.454 | |
2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.454 | |
2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.454 | |
2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
2y30 | SM8 | Putative repressor SimReg2 | / | 0.454 | |
3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.454 | |
3sgx | 0FW | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.454 | |
3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.454 | |
4c4f | 7CE | Dual specificity protein kinase TTK | 2.7.12.1 | 0.454 | |
4ful | 0VU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
4fz7 | 0VH | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.454 | |
4xr9 | TMP | CalS8 | / | 0.454 | |
4ysj | ADP | Calmodulin-like domain protein kinase | / | 0.454 | |
1err | RAL | Estrogen receptor | / | 0.453 | |
1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
2hb7 | O1C | Vitamin D3 receptor | / | 0.453 | |
2qdx | FAD | Ferredoxin--NADP+ reductase | / | 0.453 | |
2yfe | YFE | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
2z7q | ACP | Ribosomal protein S6 kinase alpha-1 | 2.7.11.1 | 0.453 | |
2zbz | VDX | Vitamin D3 dihydroxylase | / | 0.453 | |
4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
4jqh | 1MF | Alr2278 protein | / | 0.453 | |
4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
1ir3 | ANP | Insulin receptor | 2.7.10.1 | 0.452 | |
1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.452 | |
1rby | KEU | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.452 | |
1xuo | LA1 | Integrin alpha-L | / | 0.452 | |
2jiz | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.452 | |
3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.452 | |
3av7 | KYN | Uncharacterized protein | / | 0.452 | |
3bhe | BZN | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.452 | |
4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.452 | |
4nxw | ADP | Mitochondrial dynamics protein MID51 | / | 0.452 | |
4o7u | THF | Thymidylate synthase | / | 0.452 | |
5c1o | ANP | D-alanine--D-alanine ligase | / | 0.452 | |
1fnn | ADP | ORC1-type DNA replication protein | / | 0.451 | |
1i58 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.451 | |
2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
3cse | N22 | Uncharacterized protein | / | 0.451 | |
3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.451 | |
3fl8 | RAR | Dihydrofolate reductase | / | 0.451 | |
3o6o | 94M | Heat shock protein 83 | / | 0.451 | |
3vt4 | 5YI | Vitamin D3 receptor | / | 0.451 | |
3w5p | 4OA | Vitamin D3 receptor | / | 0.451 | |
4h6r | FDA | Proline dehydrogenase | / | 0.451 | |
4i3w | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.451 | |
4nxv | GDP | Mitochondrial dynamics protein MID51 | / | 0.451 | |
4o0w | ADN | Aurora kinase A | 2.7.11.1 | 0.451 | |
4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.451 | |
4ysw | FAD | Xanthine dehydrogenase/oxidase | / | 0.451 | |
5iw5 | NMN | NADH pyrophosphatase | / | 0.451 | |
1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.450 | |
1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
1lco | PPY | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.450 | |
1qxo | FMN | Chorismate synthase | / | 0.450 | |
1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.450 | |
2exc | JNK | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.450 | |
2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
2vv9 | IM9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
3ics | ADP | Coenzyme A disulfide reductase | / | 0.450 | |
3n8y | DIF | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.450 | |
3vt6 | 5YI | Vitamin D3 receptor | / | 0.450 | |
3w0a | DS5 | Vitamin D3 receptor | / | 0.450 | |
4edz | 0O5 | Hematopoietic prostaglandin D synthase | / | 0.450 | |
4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.450 | |
4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
5c03 | AGS | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.450 | |
1g4s | TPS | Thiamine-phosphate synthase | / | 0.449 | |
1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
1pmn | 984 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.449 | |
1s0z | EB1 | Vitamin D3 receptor | / | 0.449 | |
3vs2 | VSB | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.449 | |
4a4v | YFD | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.449 | |
1byg | STU | Tyrosine-protein kinase CSK | / | 0.448 | |
1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.448 | |
2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
2dqs | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.448 | |
2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.448 | |
2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.448 | |
2yit | YIT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.448 | |
3dat | MTX | Dihydrofolate reductase | / | 0.448 | |
3nc9 | TR3 | Ketohexokinase | / | 0.448 | |
3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
3tti | KBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.448 | |
4a4w | YFB | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
4bbh | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
4dgn | LU2 | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.448 | |
4ez7 | 2AN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
4k1b | 1OC | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
1dkf | BMS | Retinoic acid receptor alpha | / | 0.447 | |
1e8w | QUE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
1ict | T44 | Transthyretin | / | 0.447 | |
1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.447 | |
1t1s | CBQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.447 | |
2etr | Y27 | Rho-associated protein kinase 1 | 2.7.11.1 | 0.447 | |
2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.447 | |
2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
2qa2 | FAD | Polyketide oxygenase CabE | / | 0.447 | |
2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.447 | |
2z3u | CRR | Cytochrome P450 | / | 0.447 | |
3cs8 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.447 | |
3nsz | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
3p3z | P3Z | Putative cytochrome P450 | / | 0.447 | |
3vt9 | YI4 | Vitamin D3 receptor | / | 0.447 | |
3w0c | 6DS | Vitamin D3 receptor | / | 0.447 | |
4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.447 | |
4cta | ATP | CinA-like protein | / | 0.447 | |
4i0t | 1B6 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.447 | |
4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.446 | |
1ht5 | FL2 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.446 | |
1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.446 | |
1xjd | STU | Protein kinase C theta type | 2.7.11.13 | 0.446 | |
2etm | 7PY | Focal adhesion kinase 1 | 2.7.10.2 | 0.446 | |
2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.446 | |
2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.446 | |
2ydf | IO3 | Serum albumin | / | 0.446 | |
3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.446 | |
3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.446 | |
3mfu | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.446 | |
3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.446 | |
3w0y | DS4 | Vitamin D3 receptor | / | 0.446 | |
3wdl | ATP | 4-phosphopantoate--beta-alanine ligase | 6.3.2.36 | 0.446 | |
4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.446 | |
4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.446 | |
4j6i | 1JV | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.446 | |
4l45 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.446 | |
4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.446 | |
4wkq | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
1db1 | VDX | Vitamin D3 receptor | / | 0.445 | |
1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.445 | |
1h6v | NDP | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.445 | |
1p9w | ANP | Type II secretion system protein E | / | 0.445 | |
1tw2 | ERT | Carminomycin 4-O-methyltransferase DnrK | 2.1.1.292 | 0.445 | |
1tz8 | DES | Transthyretin | / | 0.445 | |
1yvj | 4ST | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.445 | |
2dwb | ANP | Aurora kinase A | 2.7.11.1 | 0.445 | |
2pz5 | ACP | Fibroblast growth factor receptor 2 | / | 0.445 | |
2q5p | 241 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
2q6s | PLB | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
3jw5 | TOP | Dihydrofolate reductase | / | 0.445 | |
3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.445 | |
4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
4bib | IEO | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.445 | |
4ft9 | H4K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
4h4q | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.445 | |
4j55 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
4jrn | ANP | Rhoptry kinase family protein | / | 0.445 | |
4l8u | 9AZ | Serum albumin | / | 0.445 | |
4lch | 1WN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.445 | |
4nye | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 0.445 | |
4ydu | ADP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.445 | |
4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.445 | |
5ce3 | ADP | Protein kinase YopO | / | 0.445 | |
5f1c | ATP | Uncharacterized protein | / | 0.445 | |
1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.444 | |
1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
1kgj | FL8 | Transthyretin | / | 0.444 | |
1o6k | ANP | RAC-beta serine/threonine-protein kinase | 2.7.11.1 | 0.444 | |
1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.444 | |
1xr1 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
2a4n | COA | Aac(6')-Ii protein | / | 0.444 | |
2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.444 | |
2pdt | FAD | Vivid PAS protein VVD | / | 0.444 | |
2vcw | ZZA | Hematopoietic prostaglandin D synthase | / | 0.444 | |
2vxo | XMP | GMP synthase [glutamine-hydrolyzing] | 6.3.5.2 | 0.444 | |
2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.444 | |
2zpa | ADP | tRNA(Met) cytidine acetyltransferase TmcA | / | 0.444 | |
3at4 | CCK | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
3h0s | B38 | Acetyl-CoA carboxylase | / | 0.444 | |
3iss | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.444 | |
3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.444 | |
3vrw | YS5 | Vitamin D3 receptor | / | 0.444 | |
3w5r | LOA | Vitamin D3 receptor | / | 0.444 | |
4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.444 | |
4ele | 31I | Dihydrofolate reductase | / | 0.444 | |
4f1s | F1S | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
4h98 | 14Q | Uncharacterized protein | / | 0.444 | |
4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.444 | |
4ys0 | ADP | Protein translocase subunit SecA | / | 0.444 | |
5c7o | NAD | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific | 1.2.1.12 | 0.444 | |
5dt4 | ATP | Aurora kinase A | 2.7.11.1 | 0.444 | |
2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.443 | |
2gn9 | UPG | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.443 | |
2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
2iut | AGS | DNA translocase FtsK | / | 0.443 | |
2j4z | 626 | Aurora kinase A | 2.7.11.1 | 0.443 | |
2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.443 | |
2vwy | 7X5 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.443 | |
2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.443 | |
3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
3jyn | NDP | Quinone oxidoreductase | / | 0.443 | |
3kdu | NKS | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.443 | |
3w0j | T08 | Vitamin D3 receptor | / | 0.443 | |
4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.443 | |
4dit | 0KD | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.443 | |
4f9w | LM4 | Mitogen-activated protein kinase 14 | / | 0.443 | |
4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.443 | |
4i2p | G73 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
4ite | TEY | Vitamin D3 receptor | / | 0.443 | |
4jl5 | ADP | Adenylate kinase | / | 0.443 | |
5amn | DTQ | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.443 | |
5eoy | ADP | Type 4 fimbrial biogenesis protein PilM | / | 0.443 | |
5fkn | TDC | Tetracycline repressor protein class D | / | 0.443 | |
1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
1i44 | ACP | Insulin receptor | 2.7.10.1 | 0.442 | |
1kl2 | FON | Serine hydroxymethyltransferase | / | 0.442 | |
1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
1s9e | ADB | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.442 | |
2ba9 | FAD | Putative aminooxidase | / | 0.442 | |
2dcn | ADP | 2-keto-3-deoxy-gluconate kinase | / | 0.442 | |
2har | OCC | Vitamin D3 receptor | / | 0.442 | |
2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
2kt4 | EB4 | Extracellular fatty acid-binding protein | / | 0.442 | |
2o4j | VD4 | Vitamin D3 receptor | / | 0.442 | |
2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.442 | |
2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.442 | |
3l08 | ZIG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
3qa2 | XNA | Ketohexokinase | / | 0.442 | |
3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.442 | |
3zon | IK1 | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.442 | |
4qkn | JMS | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.442 | |
5drd | ATP | Aurora kinase A | 2.7.11.1 | 0.442 | |
1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
1l2j | ETC | Estrogen receptor beta | / | 0.441 | |
1pyx | ANP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.441 | |
1rkh | VD2 | Vitamin D3 receptor | / | 0.441 | |
1s19 | MC9 | Vitamin D3 receptor | / | 0.441 | |
1t0i | FMN | NAD(P)H-dependent FMN reductase LOT6 | / | 0.441 | |
1txi | TX5 | Vitamin D3 receptor | / | 0.441 | |
2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.441 | |
2b9w | FAD | Putative aminooxidase | / | 0.441 | |
2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
2h96 | 893 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.441 | |
2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.441 | |
2nli | FMN | Lactate oxidase | / | 0.441 | |
2o2u | 738 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.441 | |
2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
2vnh | FAD | NADPH:ferredoxin reductase | / | 0.441 | |
2z9d | FMN | FMN-dependent NADH-azoreductase | / | 0.441 | |
3a1l | 2CC | Cytochrome P450 | / | 0.441 | |
3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
3ama | SKE | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
3cly | ACP | Fibroblast growth factor receptor 2 | / | 0.441 | |
3f8k | COA | Uncharacterized protein | / | 0.441 | |
3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
3jwc | EKB | Dihydrofolate reductase | / | 0.441 | |
3kxo | KXO | Hematopoietic prostaglandin D synthase | / | 0.441 | |
3okx | SAM | S-adenosyl-L-methionine-binding protein RPA0152 | / | 0.441 | |
3orp | AGS | Serine/threonine protein kinase | / | 0.441 | |
3qai | XNN | Ketohexokinase | / | 0.441 | |
3qqs | 17C | Anthranilate phosphoribosyltransferase | / | 0.441 | |
3vrv | YSD | Vitamin D3 receptor | / | 0.441 | |
4a2a | ATP | Cell division protein FtsA | / | 0.441 | |
4a33 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.441 | |
4em9 | TCE | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
4fv0 | EK3 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.441 | |
4kwi | 1TJ | Reductase homolog | / | 0.441 | |
4l9q | 9TP | Serum albumin | / | 0.441 | |
4lvb | 20N | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.441 | |
4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.441 | |
4z07 | PCG | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.441 | |
5iqh | GNP | Bifunctional AAC/APH | 2.3.1 | 0.441 | |
5k2b | ZMA | Adenosine receptor A2a | / | 0.441 | |
1dj3 | GDP | Adenylosuccinate synthetase, chloroplastic | / | 0.440 | |
1e1m | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.440 | |
1h9z | RWF | Serum albumin | / | 0.440 | |
1m2p | HNA | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
1mr9 | ACO | Streptogramin A acetyltransferase | 2.3.1 | 0.440 | |
1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.440 | |
2bx8 | AZQ | Serum albumin | / | 0.440 | |
2bxn | IDB | Serum albumin | / | 0.440 | |
2bxo | OPB | Serum albumin | / | 0.440 | |
2c0t | L3G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.440 | |
2ham | C33 | Vitamin D3 receptor | / | 0.440 | |
2hbh | XE4 | Vitamin D3 receptor A | / | 0.440 | |
2j7t | 274 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.440 | |
2rgh | FAD | Alpha-Glycerophosphate Oxidase | / | 0.440 | |
3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
3k5u | PFQ | Aurora kinase A | 2.7.11.1 | 0.440 | |
3ori | AGS | Serine/threonine protein kinase | / | 0.440 | |
3ork | AGS | Serine/threonine protein kinase | / | 0.440 | |
3q9x | EMO | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
3stv | 3HO | Methylketone synthase I | / | 0.440 | |
3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
3vt3 | VDX | Vitamin D3 receptor | / | 0.440 | |
4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.440 | |
4feh | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.440 | |
4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.440 | |
4gub | 0Y4 | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.440 | |
4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.440 | |
4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 |