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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3n14FMNXenobiotic reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3n14FMNXenobiotic reductase/1.000
3l5lFMNXenobiotic reductase/0.769
4uthFMNXenobiotic reductase/0.707
2h8xFMNXenA/0.633
3l67FMNXenobiotic reductase/0.617
3hf3FMNChromate reductase/0.546
1z44FMNNADPH dehydrogenase/0.543
3n19FNRXenobiotic reductase/0.516
4utlFNRXenobiotic reductase/0.493
3p74FMNPentaerythritol tetranitrate reductase/0.491
3kruFMNNADH:flavin oxidoreductase/NADH oxidase/0.484
1icqFMN12-oxophytodienoate reductase 11.3.1.420.481
3p67FMNPentaerythritol tetranitrate reductase/0.476
1s63778Protein farnesyltransferase subunit beta2.5.1.580.472
1vyrFMNPentaerythritol tetranitrate reductase/0.472
2gesCOKPantothenate kinase2.7.1.330.472
3f03FMNPentaerythritol tetranitrate reductase/0.472
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.465
4lutDCSAlanine racemase/0.463
1h51FMNPentaerythritol tetranitrate reductase/0.461
1icpFMN12-oxophytodienoate reductase 11.3.1.420.459
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.457
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.457
3hgsFMN12-oxophytodienoate reductase 31.3.1.420.457
3p62FMNPentaerythritol tetranitrate reductase/0.457
4b65FADL-ornithine N(5)-monooxygenase/0.457
4rnvFMNNADPH dehydrogenase 11.6.99.10.456
3q7fED2Uncharacterized protein/0.455
2zsaADPPantothenate kinase2.7.1.330.454
3hgrFMN12-oxophytodienoate reductase 11.3.1.420.454
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.453
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.453
2getCOKPantothenate kinase2.7.1.330.453
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.452
3hgoFMN12-oxophytodienoate reductase 31.3.1.420.452
2bf4FMNNADPH--cytochrome P450 reductase/0.450
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.450
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.449
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.448
3pz43PZProtein farnesyltransferase subunit beta2.5.1.580.448
1icsFMN12-oxophytodienoate reductase 11.3.1.420.447
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.447
3p8jFMNPentaerythritol tetranitrate reductase/0.447
4df2FMNNADPH dehydrogenase/0.447
4rvfTYDD-mycarose 3-C-methyltransferase/0.447
4utkFNRXenobiotic reductase/0.447
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.445
3p8iFMNPentaerythritol tetranitrate reductase/0.445
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.445
4b66FADL-ornithine N(5)-monooxygenase/0.445
5fd8A5APutative carboxypeptidase yocD/0.445
1h50FMNPentaerythritol tetranitrate reductase/0.444
2hs8FMN12-oxophytodienoate reductase 31.3.1.420.444
2xuoTZ4Acetylcholinesterase3.1.1.70.444
1h63FMNPentaerythritol tetranitrate reductase/0.443
1vf3GDNGlutathione S-transferase 32.5.1.180.443
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.443
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.442
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.442
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.441
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.441
2abbFMNPentaerythritol tetranitrate reductase/0.441
3hl0NADMaleylacetate reductase/0.441
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.441
4bfyZVYPantothenate kinase2.7.1.330.441
4rnuFMNNADPH dehydrogenase 11.6.99.10.441
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.440
4qnwFMNChanoclavine-I aldehyde reductase easA/0.440