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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3mwuBK3Calmodulin-domain protein kinase 1, putative

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3mwuBK3Calmodulin-domain protein kinase 1, putative/1.000
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.540
2ghlLIBMitogen-activated protein kinase 14/0.524
3dt1P40Mitogen-activated protein kinase 14/0.495
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.485
4ih8B43Calmodulin-domain protein kinase 1/0.485
3igoANPCalmodulin-domain protein kinase 1, putative/0.482
2po7CHDFerrochelatase, mitochondrial4.99.1.10.480
3l8p0CEAngiopoietin-1 receptor2.7.10.10.478
4mxaBK7Calmodulin-like domain protein kinase isoenzyme gamma, related/0.478
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.476
3owaFADAcyl-CoA dehydrogenase/0.474
3gw9VNILanosterol 14-alpha-demethylase/0.473
3hllI45Mitogen-activated protein kinase 14/0.473
1xl5190Gag-Pol polyprotein3.4.23.160.472
1zz2B11Mitogen-activated protein kinase 14/0.471
3hx4ANPCalmodulin-domain protein kinase 1/0.471
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.470
1jioDEB6-deoxyerythronolide B hydroxylase/0.468
3fklFKLMitogen-activated protein kinase 14/0.468
3hvcGG5Mitogen-activated protein kinase 14/0.468
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.468
3tqhNDPQuinone oxidoreductase/0.468
1fm4DXCMajor pollen allergen Bet v 1-L/0.467
4nk92K5Fibroblast growth factor receptor 1/0.465
2zevB71Geranylgeranyl pyrophosphate synthase/0.463
4kip1R9Mitogen-activated protein kinase 14/0.462
4fnyI3KALK tyrosine kinase receptor2.7.10.10.460
1egeFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.458
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.458
3flwFLWMitogen-activated protein kinase 14/0.458
1bygSTUTyrosine-protein kinase CSK/0.457
3slkNDPPolyketide synthase extender module 2/0.457
3tnlNADShikimate dehydrogenase (NADP(+))/0.457
1vikBAYGag-Pol polyprotein/0.456
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.456
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.456
3ttjJBIMitogen-activated protein kinase 102.7.11.240.456
2p3b3TLV-1 PROTEASE protein/0.455
2p3b3TLV-1 protease/0.455
3hl7I47Mitogen-activated protein kinase 14/0.455
3oev3OEProteasome subunit beta type-53.4.25.10.455
3oev3OEProteasome subunit beta type-63.4.25.10.455
4aotGW8Serine/threonine-protein kinase 102.7.11.10.455
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.455
1k6cMK1Gag-Pol polyprotein3.4.23.160.454
1yb5NAPQuinone oxidoreductase1.6.5.50.454
3s4qNK0Mitogen-activated protein kinase 14/0.454
4g7gVFVLanosterol 14-alpha-demethylase/0.454
1jkx138Phosphoribosylglycinamide formyltransferase/0.453
3cs8BRLPeroxisome proliferator-activated receptor gamma/0.453
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.453
4aa5NQBMitogen-activated protein kinase 14/0.453
1hosPHPGag-Pol polyprotein/0.452
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.452
3p4tFAOPutative acyl-CoA dehydrogenase/0.452
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.452
3w33W19Epidermal growth factor receptor2.7.10.10.452
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.452
4loqSB4Mitogen-activated protein kinase 14/0.452
4nka2K7Fibroblast growth factor receptor 1/0.452
1k6pXN3Gag-Pol polyprotein3.4.23.160.451
2excJNKMitogen-activated protein kinase 102.7.11.240.451
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.451
3r7kFDAProbable acyl CoA dehydrogenase/0.451
3w2sW2REpidermal growth factor receptor2.7.10.10.451
4g3jVNTLanosterol 14-alpha-demethylase/0.451
4i22IREEpidermal growth factor receptor2.7.10.10.451
1gpdNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.450
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.450
3nww3NWMitogen-activated protein kinase 14/0.450
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.449
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.449
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.449
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.449
2q9fC3SCholesterol 24-hydroxylase/0.448
3l0lHC3Nuclear receptor ROR-gamma/0.448
3t2zFADSulfide-quinone reductase/0.447
4ejmNAPPutative zinc-binding dehydrogenase/0.447
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.446
2ien017Gag-Pol polyprotein3.4.23.160.446
2w3bNDPDihydrofolate reductase1.5.1.30.446
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.446
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.446
3gu83GUDeath-associated protein kinase 12.7.11.10.446
3tvuB37Acetyl-CoA carboxylase/0.446
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.446
4lopSB4Mitogen-activated protein kinase 14/0.446
4yuqKS1Calmodulin-like domain protein kinase/0.446
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.446
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.446
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.445
2ckeIQUDeath-associated protein kinase 2/0.445
3eteNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.445
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.445
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.445
3zuxTCHTransporter/0.445
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
1bxoPP7Penicillopepsin-13.4.23.200.444
1iyzNDPProbable quinone oxidoreductase/0.444
1xkdNAPIsocitrate dehydrogenase [NADP]/0.444
1zys199Serine/threonine-protein kinase Chk12.7.11.10.444
2o0uC0MMitogen-activated protein kinase 102.7.11.240.444
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3ttiKBIMitogen-activated protein kinase 102.7.11.240.444
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4q71FADBifunctional protein PutA/0.444
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.443
3el4ROCGag-Pol polyprotein3.4.23.160.443
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.443
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.443
2pd8FADVivid PAS protein VVD/0.442
2vzmNRBCytochrome P450 monooxygenase PikC/0.442
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.442
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.442
3lzs017Gag-Pol polyprotein3.4.23.160.442
3mg3ECHOrange carotenoid-binding protein/0.442
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.442
4a6bQG8Gag-Pol polyprotein3.4.23.160.442
4jbqVX6Aurora kinase A2.7.11.10.442
4kin1M8Mitogen-activated protein kinase 14/0.442
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.441
2nuaCOASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.441
2p33J07Mitogen-activated protein kinase 102.7.11.240.441
2q61SF1Peroxisome proliferator-activated receptor gamma/0.441
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.441
3p6oETGCamphor 5-monooxygenase1.14.15.10.441
4a4vYFDPeroxisome proliferator-activated receptor gamma/0.441
4dfg0JVGag-Pol polyprotein3.4.23.160.441
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.441
4y95746Tyrosine-protein kinase/0.441
2ad5ADPCTP synthase/0.440
2c6eHPMAurora kinase A2.7.11.10.440
3cgoJNOMitogen-activated protein kinase 102.7.11.240.440
3uyt0CKCasein kinase I isoform delta2.7.11.10.440
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.440
4i8zG08Gag-Pol polyprotein3.4.23.160.440