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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3mvl38PMitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3mvl38PMitogen-activated protein kinase 14/1.000
1zyjBI5Mitogen-activated protein kinase 14/0.588
3nww3NWMitogen-activated protein kinase 14/0.572
4aacAAVMitogen-activated protein kinase 14/0.572
3s4qNK0Mitogen-activated protein kinase 14/0.569
3uvqFS8Mitogen-activated protein kinase 14/0.559
3fln3FNMitogen-activated protein kinase 14/0.554
3hl7I47Mitogen-activated protein kinase 14/0.553
4aa4QC0Mitogen-activated protein kinase 14/0.545
4kiq1RAMitogen-activated protein kinase 14/0.542
4kip1R9Mitogen-activated protein kinase 14/0.539
3flyFLYMitogen-activated protein kinase 14/0.531
3roc29AMitogen-activated protein kinase 14/0.531
3fklFKLMitogen-activated protein kinase 14/0.529
3uvp048Mitogen-activated protein kinase 14/0.528
3fi4FI4Mitogen-activated protein kinase 14/0.526
3hllI45Mitogen-activated protein kinase 14/0.525
4aa5NQBMitogen-activated protein kinase 14/0.525
2rg6287Mitogen-activated protein kinase 14/0.524
3mpaSB2Mitogen-activated protein kinase 14/0.523
4lopSB4Mitogen-activated protein kinase 14/0.523
3l8xN4DMitogen-activated protein kinase 14/0.522
3flzFLZMitogen-activated protein kinase 14/0.518
3fmkFMKMitogen-activated protein kinase 14/0.518
2balPQAMitogen-activated protein kinase 14/0.517
2rg5279Mitogen-activated protein kinase 14/0.515
3w33W19Epidermal growth factor receptor2.7.10.10.515
3dt1P40Mitogen-activated protein kinase 14/0.513
4nka2K7Fibroblast growth factor receptor 1/0.513
1ywrLI9Mitogen-activated protein kinase 14/0.512
2qd9LGFMitogen-activated protein kinase 14/0.512
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.512
3iphG11Mitogen-activated protein kinase 14/0.509
2fgiPD1Fibroblast growth factor receptor 1/0.503
4nk92K5Fibroblast growth factor receptor 1/0.502
4nks2M2Fibroblast growth factor receptor 1/0.502
3fmh533Mitogen-activated protein kinase 14/0.501
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.501
4f640S8Fibroblast growth factor receptor 1/0.501
4yuqKS1Calmodulin-like domain protein kinase/0.501
3hvcGG5Mitogen-activated protein kinase 14/0.500
4kin1M8Mitogen-activated protein kinase 14/0.500
3gc9B45Mitogen-activated protein kinase 112.7.11.240.498
3gubGUBDeath-associated protein kinase 12.7.11.10.495
3kf7L9GMitogen-activated protein kinase 14/0.494
4nc3ERM5-hydroxytryptamine receptor 2B/0.494
3gfeP37Mitogen-activated protein kinase 14/0.493
4c4h7RODual specificity protein kinase TTK2.7.12.10.493
3flwFLWMitogen-activated protein kinase 14/0.492
3ocgOCGMitogen-activated protein kinase 14/0.492
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.492
3flsFLSMitogen-activated protein kinase 14/0.491
3hp552PMitogen-activated protein kinase 14/0.491
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.489
1zz2B11Mitogen-activated protein kinase 14/0.488
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.488
3fmn530Mitogen-activated protein kinase 14/0.487
4ewqMWLMitogen-activated protein kinase 14/0.487
2ghlLIBMitogen-activated protein kinase 14/0.486
2ghmLICMitogen-activated protein kinase 14/0.486
4b99R4LMitogen-activated protein kinase 72.7.11.240.485
4hnf16WCasein kinase I isoform delta2.7.11.10.485
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.485
4loqSB4Mitogen-activated protein kinase 14/0.485
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.484
1ouy094Mitogen-activated protein kinase 14/0.483
3bv3P39Mitogen-activated protein kinase 14/0.483
4looSB4Mitogen-activated protein kinase 14/0.483
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.483
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.482
1xkkFMMEpidermal growth factor receptor2.7.10.10.481
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.481
4i22IREEpidermal growth factor receptor2.7.10.10.481
1m7qDQOMitogen-activated protein kinase 14/0.480
2ittAEEEpidermal growth factor receptor2.7.10.10.479
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.479
3vryB43Tyrosine-protein kinase HCK2.7.10.20.479
4ic7ANPMitogen-activated protein kinase 72.7.11.240.478
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.478
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.477
3uyt0CKCasein kinase I isoform delta2.7.11.10.477
4bcqTJFCyclin-dependent kinase 22.7.11.220.477
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.476
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.475
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.474
4kbk1QGCasein kinase I isoform delta2.7.11.10.474
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.473
3fc152PMitogen-activated protein kinase 14/0.473
1ove358Mitogen-activated protein kinase 14/0.472
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.471
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.471
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.469
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.469
3mpt1GKMitogen-activated protein kinase 14/0.469
4c4f7CEDual specificity protein kinase TTK2.7.12.10.469
4fuxE75Mitogen-activated protein kinase 12.7.11.240.469
2j0k4STFocal adhesion kinase 12.7.10.20.468
3obgSB2Mitogen-activated protein kinase 14/0.467
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.467
4f9wLM4Mitogen-activated protein kinase 14/0.467
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.466
4eh60ONMitogen-activated protein kinase 14/0.465
4jq8KJ8Epidermal growth factor receptor2.7.10.10.465
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.464
1pkdUCNCyclin-dependent kinase 22.7.11.220.463
1v0pPVBCell division control protein 2 homolog2.7.11.220.463
2wouZZFTGF-beta receptor type-12.7.11.300.463
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.463
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.463
3l8p0CEAngiopoietin-1 receptor2.7.10.10.463
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.463
1aq1STUCyclin-dependent kinase 22.7.11.220.462
3fskRO6Mitogen-activated protein kinase 14/0.462
2i0ePDSProtein kinase C beta type2.7.11.130.461
2itzIREEpidermal growth factor receptor2.7.10.10.461
3iqeF42F420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.461
3ttiKBIMitogen-activated protein kinase 102.7.11.240.461
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.461
4c4g7RODual specificity protein kinase TTK2.7.12.10.461
4j54G52Gag-Pol polyprotein3.4.23.160.461
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.461
2itpAEEEpidermal growth factor receptor2.7.10.10.460
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.460
3gc7B45Mitogen-activated protein kinase 14/0.460
4f630S7Fibroblast growth factor receptor 1/0.460
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.460
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.459
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.459
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.459
4g170VNCasein kinase I isoform gamma-32.7.11.10.459
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.458
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.458
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.458
3zsi52PMitogen-activated protein kinase 14/0.458
1h1s4SPCyclin-dependent kinase 22.7.11.220.457
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.457
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.457
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.457
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.457
4anqVGHALK tyrosine kinase receptor2.7.10.10.457
4gmy0X5Tyrosine-protein kinase JAK2/0.457
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.457
4ye3G04Gag-Pol polyprotein3.4.23.160.457
5e8xSTUTGF-beta receptor type-12.7.11.300.457
1gih1PUCyclin-dependent kinase 22.7.11.220.456
1yw2PGJMitogen-activated protein kinase 14/0.456
4ez50RSCyclin-dependent kinase 62.7.11.220.456
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.456
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.456
1ouk084Mitogen-activated protein kinase 14/0.455
1vjy460TGF-beta receptor type-12.7.11.300.455
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.455
4gk2L66Ephrin type-A receptor 32.7.10.10.455
4ix6ADPUncharacterized protein/0.455
4nj32KDCyclin-dependent kinase 22.7.11.220.455
2excJNKMitogen-activated protein kinase 102.7.11.240.454
2w05FRTCyclin-dependent kinase 22.7.11.220.454
2wecPP5Penicillopepsin-13.4.23.200.454
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.454
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.454
2e9cB75Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.453
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.453
2iw84SPCyclin-dependent kinase 22.7.11.220.453
2vynNADGlyceraldehyde-3-phosphate dehydrogenase A/0.453
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.453
3lltANPProtein serine/threonine kinase-1/0.453
3oom507Activin receptor type-12.7.11.300.453
4ansVGHALK tyrosine kinase receptor2.7.10.10.453
4fkt48KCyclin-dependent kinase 22.7.11.220.453
4fnyI3KALK tyrosine kinase receptor2.7.10.10.453
4lggVGGProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
5aaaVGHALK tyrosine kinase receptor2.7.10.10.453
5e8wSTUTGF-beta receptor type-12.7.11.300.453
2of2547Tyrosine-protein kinase Lck2.7.10.20.452
2wotZZGTGF-beta receptor type-12.7.11.300.452
2zb0GK3Mitogen-activated protein kinase 14/0.452
3iw4LW4Protein kinase C alpha type2.7.11.130.452
3nbwTR4Ketohexokinase/0.452
3zuxTCHTransporter/0.452
4bi1ZO6Dual specificity protein kinase TTK2.7.12.10.452
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.452
4g1wG1WMitogen-activated protein kinase 82.7.11.240.452
4kb81QNCasein kinase I isoform delta2.7.11.10.452
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.452
1k6cMK1Gag-Pol polyprotein3.4.23.160.451
2hog710Serine/threonine-protein kinase Chk12.7.11.10.451
2x1nX1NCyclin-dependent kinase 22.7.11.220.451
3lfqA28Cyclin-dependent kinase 22.7.11.220.451
3u8w09JMitogen-activated protein kinase 14/0.451
3w32W32Epidermal growth factor receptor2.7.10.10.451
4erwSTUCyclin-dependent kinase 22.7.11.220.451
4fob0USALK tyrosine kinase receptor2.7.10.10.451
2j7t274Serine/threonine-protein kinase 102.7.11.10.450
4eh70OOMitogen-activated protein kinase 14/0.450
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.450
4ih8B43Calmodulin-domain protein kinase 1/0.450
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.450
1fvt106Cyclin-dependent kinase 22.7.11.220.449
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
2o0uC0MMitogen-activated protein kinase 102.7.11.240.449
3fl4FL4Mitogen-activated protein kinase 14/0.449
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.449
3ormAGSSerine/threonine protein kinase/0.449
3q92XNBKetohexokinase/0.449
3sa6F71Protease/0.449
4hyu1BKMitogen-activated protein kinase 82.7.11.240.449
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.449
1j39UPGDNA beta-glucosyltransferase/0.448
1oi9N20Cyclin-dependent kinase 22.7.11.220.448
2izsBRQCasein kinase I isoform gamma-32.7.11.10.448
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.448
3fkoFKOMitogen-activated protein kinase 14/0.448
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.448
4ib4ERM5-hydroxytryptamine receptor 2B/0.448
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.448
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.448
1cm8ANPMitogen-activated protein kinase 12/0.447
1oirHDYCyclin-dependent kinase 22.7.11.220.447
3r9dX6BCyclin-dependent kinase 22.7.11.220.447
4bcoT6QCyclin-dependent kinase 22.7.11.220.447
4r20AERCytochrome P450 family 17 polypeptide 2/0.447
1finATPCyclin-dependent kinase 22.7.11.220.446
1ke6LS2Cyclin-dependent kinase 22.7.11.220.446
1oiyN41Cyclin-dependent kinase 22.7.11.220.446
2baqPQBMitogen-activated protein kinase 14/0.446
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
2h96893Mitogen-activated protein kinase 82.7.11.240.446
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.446
3poz03PEpidermal growth factor receptor2.7.10.10.446
3v3vMYUMitogen-activated protein kinase 82.7.11.240.446
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.446
4id71G0Activated CDC42 kinase 1/0.446
4kbc1QJCasein kinase I isoform delta2.7.11.10.446
4qmzB49Serine/threonine-protein kinase 242.7.11.10.446
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.446
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.445
2c475IDCasein kinase I isoform gamma-2/0.445
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.445
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.445
3bqr4RBDeath-associated protein kinase 3/0.445
3gu83GUDeath-associated protein kinase 12.7.11.10.445
3zewSTUEphrin type-B receptor 42.7.10.10.445
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.445
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4fv9E71Mitogen-activated protein kinase 12.7.11.240.445
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.445
4othDRNSerine/threonine-protein kinase N1/0.445
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.445
1k6tXN1Gag-Pol polyprotein3.4.23.160.444
1m17AQ4Epidermal growth factor receptor2.7.10.10.444
1r78FMDCyclin-dependent kinase 22.7.11.220.444
2c7xNRBCytochrome P450 monooxygenase PikC/0.444
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.444
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.444
3djkG55Gag-Pol polyprotein3.4.23.160.444
3ha85JZMitogen-activated protein kinase 14/0.444
3rni21ZCyclin-dependent kinase 22.7.11.220.444
3ttjJBIMitogen-activated protein kinase 102.7.11.240.444
3upjU03Gag-Pol polyprotein/0.444
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4iaq2GM5-hydroxytryptamine receptor 1B/0.444
4j97ACPFibroblast growth factor receptor 2/0.444
4o701QKBromodomain-containing protein 4/0.444
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.444
1z1rHBHGag-Pol polyprotein3.4.23.160.443
2b1pAIZMitogen-activated protein kinase 102.7.11.240.443
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.443
2nu9COASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.443
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.443
2zb1GK4Mitogen-activated protein kinase 14/0.443
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.443
3d7tSTUTyrosine-protein kinase CSK/0.443
3gxoMQAMitomycin biosynthesis 6-O-methyltransferase/0.443
3js2VM1Fibroblast growth factor receptor 1/0.443
3mtfA3FActivin receptor type-12.7.11.300.443
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.443
4f650S9Fibroblast growth factor receptor 1/0.443
4fnzNZFALK tyrosine kinase receptor2.7.10.10.443
4gt3ATPMitogen-activated protein kinase 12.7.11.240.443
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.443
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4kba1QMCasein kinase I isoform delta2.7.11.10.443
1fvv107Cyclin-dependent kinase 22.7.11.220.442
1k6pXN3Gag-Pol polyprotein3.4.23.160.442
1u4dDBQActivated CDC42 kinase 1/0.442
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.442
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.442
2w4iVGAGlutamate racemase/0.442
3s2pPMUCyclin-dependent kinase 22.7.11.220.442
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.442
4c4jX21Dual specificity protein kinase TTK2.7.12.10.442
4jq7KJQEpidermal growth factor receptor2.7.10.10.442
4q73FADBifunctional protein PutA/0.442
1ppjSMACytochrome b/0.441
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.441
1wvxBD4Death-associated protein kinase 12.7.11.10.441
1xjdSTUProtein kinase C theta type2.7.11.130.441
2itnANPEpidermal growth factor receptor2.7.10.10.441
2uzlC94Cyclin-dependent kinase 22.7.11.220.441
2yfxVGHALK tyrosine kinase receptor2.7.10.10.441
3a2oKNJGag-Pol polyprotein3.4.23.160.441
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.441
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.441
3vquO22Dual specificity protein kinase TTK2.7.12.10.441
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.441
3w2rW2REpidermal growth factor receptor2.7.10.10.441
4jrvKJVEpidermal growth factor receptor2.7.10.10.441
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.441
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.441
4q71FADBifunctional protein PutA/0.441
4qms1N1Serine/threonine-protein kinase 242.7.11.10.441
1bygSTUTyrosine-protein kinase CSK/0.440
1hiiC20Gag-Pol polyprotein/0.440
1py5PY1TGF-beta receptor type-12.7.11.300.440
1vyzN5BCyclin-dependent kinase 22.7.11.220.440
2bpz3INGag-Pol polyprotein3.4.23.160.440
2ieo017Protease/0.440
3a60STURibosomal protein S6 kinase beta-12.7.11.10.440
3itzP66Mitogen-activated protein kinase 14/0.440
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.440
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.440
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.440
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.440
4o761M3Bromodomain-containing protein 4/0.440
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.440