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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3mp5HMGHydroxymethylglutaryl-CoA lyase, mitochondrial4.1.3.4

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3mp5HMGHydroxymethylglutaryl-CoA lyase, mitochondrial4.1.3.41.000
3mp3HGGHydroxymethylglutaryl-CoA lyase, mitochondrial4.1.3.40.594
4tvbNADHomospermidine synthase2.5.1.440.458
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.456
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.456
1t2aNDPGDP-mannose 4,6 dehydratase4.2.1.470.446