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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3mn6ATPActin-5C

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3mn6ATPActin-5C/1.000
3mn9ATPActin-5C/0.573
4cbxATPActin-2/0.570
1qz5ATPActin, alpha skeletal muscle/0.563
4jhdANPActin-5C/0.541
1lotATPActin, alpha skeletal muscle/0.534
5ce3ATPActin/0.525
1c0fATPMajor actin/0.524
3el2ATPActin-5C/0.521
2q36ATPActin, alpha skeletal muscle/0.520
3tu5ATPActin, alpha skeletal muscle/0.520
3m6gATPActin, alpha skeletal muscle/0.518
4k42ADPActin, alpha skeletal muscle/0.513
4pkgATPActin, alpha skeletal muscle/0.512
1t44ATPActin, alpha skeletal muscle/0.509
3mn7ATPActin-5C/0.509
1s22ATPActin, alpha skeletal muscle/0.508
1eqyATPActin, alpha skeletal muscle/0.503
4pkhADPActin, alpha skeletal muscle/0.494
3eksATPActin-5C/0.492
4m63ATPActin-5C/0.492
3ffkATPActin, alpha skeletal muscle/0.491
3u9dATPActin, alpha skeletal muscle/0.491
1ijjATPActin, alpha skeletal muscle/0.487
1nmdATPMajor actin/0.485
4k41ATPActin, alpha skeletal muscle/0.485
3a5mATPMajor actin/0.484
1h1vATPActin, alpha skeletal muscle/0.483
4pl8ATPActin, alpha skeletal muscle/0.483
4ci6ATPActin/0.482
1rgiATPActin, alpha skeletal muscle/0.477
1yxqATPActin, alpha skeletal muscle/0.477
1nm1ATPMajor actin/0.470
3u4lATPActin, cytoplasmic 1/0.469
3m1fATPActin, alpha skeletal muscle/0.467
2p9kATPActin-related protein 2/0.466
2v51ATPActin, alpha skeletal muscle/0.462
3dawATPActin, alpha skeletal muscle/0.457
4k43ADPActin, alpha skeletal muscle/0.455
2oanATPActin, cytoplasmic 1/0.452
4pkiATPActin, alpha skeletal muscle/0.451
3w3dATPActin, gamma-enteric smooth muscle/0.446
4rwtANPActin-5C/0.445
2q97ATPActin, alpha skeletal muscle/0.443