sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3mje | NDP | AmphB |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3mje | NDP | AmphB | / | 1.000 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.578 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.548 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.547 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.542 | |
| 4hxy | NDP | Plm1 | / | 0.539 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.535 | |
| 4kwh | NAP | Reductase homolog | / | 0.535 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.531 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.527 | |
| 4l4x | NDP | AmphI | / | 0.524 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.519 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.519 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.518 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.516 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.515 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.511 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.510 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.509 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.509 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.504 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.503 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.502 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.501 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.500 | |
| 1i2b | NAD | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.499 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.499 | |
| 4lis | NAD | UDP-glucose 4-epimerase (Eurofung) | / | 0.497 | |
| 1u7t | TDT | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.496 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.496 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.494 | |
| 2bgm | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.492 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.491 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.491 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.491 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.490 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.490 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.489 | |
| 4u7w | NDP | MxaA | / | 0.489 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.488 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.488 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.487 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.485 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.484 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.484 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.484 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.484 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.483 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.482 | |
| 3pgx | NAD | Uncharacterized NAD-dependent oxidoreductase MAP_4146 | / | 0.482 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.481 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.480 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.479 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.479 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.479 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.479 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.478 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.478 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.477 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.477 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.475 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.474 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.474 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.473 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.473 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.473 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.473 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.472 | |
| 1ek5 | NAD | UDP-glucose 4-epimerase | / | 0.472 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.472 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.470 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.470 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.470 | |
| 3sdk | P3N | Proteasome subunit beta type-5 | 3.4.25.1 | 0.470 | |
| 3sdk | P3N | Proteasome subunit beta type-6 | 3.4.25.1 | 0.470 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.470 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.470 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.469 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.469 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.468 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.468 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.467 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.467 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.467 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.467 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.467 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.467 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.466 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.466 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.466 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.466 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.465 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.465 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.465 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.465 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.465 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.464 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.464 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.464 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.463 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.463 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.463 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.463 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.463 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.463 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.463 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.463 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.463 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.462 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.462 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.462 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.462 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.462 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.462 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.461 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.461 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.461 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.461 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.461 | |
| 4nxw | ADP | Mitochondrial dynamics protein MID51 | / | 0.461 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 1hnc | GDN | Glutathione S-transferase Mu 2 | 2.5.1.18 | 0.460 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.460 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.460 | |
| 3ggo | NAI | Prephenate dehydrogenase | / | 0.460 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.459 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.459 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.459 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.458 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.458 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.458 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.458 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.457 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.457 | |
| 2fr1 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.457 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.457 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.457 | |
| 4wx1 | FDA | UDP-galactopyranose mutase | / | 0.457 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.456 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.456 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.456 | |
| 3cif | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.456 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.456 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.456 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.456 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.456 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.456 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 1osv | CHC | Bile acid receptor | / | 0.455 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.455 | |
| 4dsh | FDA | Uncharacterized protein | / | 0.455 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.454 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.454 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.454 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.454 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.454 | |
| 5cnn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.454 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.453 | |
| 1wwk | NAD | 307aa long hypothetical phosphoglycerate dehydrogenase | / | 0.453 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.453 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.453 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.453 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.453 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.453 | |
| 4idg | NAD | Putative UDP-glucose 4-epimerase | / | 0.453 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.452 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.452 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.452 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.452 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.452 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.452 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.451 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.451 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.451 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.450 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.450 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 4o59 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.450 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.450 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.449 | |
| 2iw8 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.449 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.449 | |
| 3e5r | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic | 1.2.1.12 | 0.449 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.449 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.448 | |
| 1i3m | UD1 | UDP-glucose 4-epimerase | / | 0.448 | |
| 1nlm | UD1 | UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | / | 0.448 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.448 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.448 | |
| 1zly | DQB | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.448 | |
| 2eka | SAH | Diphthine synthase | / | 0.448 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.448 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.448 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.448 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4qmp | DKI | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.448 | |
| 5dp2 | NAP | CurF | / | 0.448 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.447 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.447 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.447 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.447 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.447 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.447 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.447 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.447 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.447 | |
| 1r2j | FAD | FkbI | / | 0.446 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.446 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2jkk | BI9 | Focal adhesion kinase 1 | 2.7.10.2 | 0.446 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.446 | |
| 2vna | NAP | Prostaglandin reductase 2 | 1.3.1.48 | 0.446 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.446 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.446 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.446 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.446 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.446 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.446 | |
| 3mk6 | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.446 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.446 | |
| 4bie | IE6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.446 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.446 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.446 | |
| 5cno | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.446 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.446 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.445 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.445 | |
| 1q12 | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.445 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.445 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.445 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.445 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.445 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.445 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.445 | |
| 3uth | FDA | UDP-galactopyranose mutase | / | 0.445 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.445 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.445 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.445 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.444 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.444 | |
| 2el0 | SAH | Diphthine synthase | / | 0.444 | |
| 2emu | SAH | Diphthine synthase | / | 0.444 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.444 | |
| 2pck | SAH | Diphthine synthase | / | 0.444 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.444 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.444 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.444 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.444 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.444 | |
| 3qfa | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.444 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.444 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.444 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.444 | |
| 3utg | FDA | UDP-galactopyranose mutase | / | 0.444 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.444 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.444 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.444 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.443 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.443 | |
| 2hrb | NAP | Carbonyl reductase [NADPH] 3 | 1.1.1.184 | 0.443 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.443 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 3d8b | ADP | Fidgetin-like protein 1 | 3.6.4 | 0.443 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.443 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.443 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.443 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.443 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.443 | |
| 4iah | 1DX | Alr2278 protein | / | 0.443 | |
| 1egd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.442 | |
| 1i8t | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.442 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 1sny | NAP | LD36273p | / | 0.442 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2e20 | B4P | Propionate kinase | / | 0.442 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.442 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.442 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.442 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.442 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.442 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.442 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.442 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.442 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.442 | |
| 4pzd | NAD | 3-Hydroxyacyl-CoA dehydrogenase | / | 0.442 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.442 | |
| 5a3c | NAD | SIR2 family protein | / | 0.442 | |
| 1bwf | ATF | Glycerol kinase | / | 0.441 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.441 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.441 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 1yba | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.441 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.441 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.441 | |
| 2qo7 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.441 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.441 | |
| 2xrl | DXT | Tetracycline repressor protein class D | / | 0.441 | |
| 2xvh | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
| 2ztu | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.441 | |
| 3i25 | MV7 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.441 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.441 | |
| 3rdq | DTB | Streptavidin | / | 0.441 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.441 | |
| 3sm2 | 478 | Putative gag-pro-pol polyprotein | / | 0.441 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.441 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.441 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.441 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.441 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.441 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.440 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1wvg | APR | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.440 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2o4c | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.440 | |
| 2ok7 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.440 | |
| 2xj2 | 985 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.440 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.440 | |
| 3lu8 | IQX | Serum albumin | / | 0.440 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.440 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.440 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.440 | |
| 4aqc | 88A | Tyrosine-protein kinase JAK2 | / | 0.440 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.440 |