sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3m6p | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3m6p | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 1.000 | |
| 3pn4 | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.637 | |
| 4e9a | QAP | Peptide deformylase | / | 0.624 | |
| 1ix1 | BB2 | Peptide deformylase | / | 0.595 | |
| 3u04 | BB2 | Peptide deformylase | / | 0.593 | |
| 2ew5 | Y12 | Peptide deformylase | / | 0.591 | |
| 1ws1 | BB2 | Peptide deformylase 1 | / | 0.568 | |
| 2ew6 | Y13 | Peptide deformylase | / | 0.568 | |
| 3o3j | BB4 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.561 | |
| 4e9b | BB2 | Peptide deformylase | / | 0.540 | |
| 1g2a | BB2 | Peptide deformylase | 3.5.1.88 | 0.535 | |
| 3uwb | BB2 | RIIA-RIIB membrane-associated protein | / | 0.519 | |
| 1lru | BB2 | Peptide deformylase | 3.5.1.88 | 0.515 | |
| 1s17 | GNR | Peptide deformylase | / | 0.515 | |
| 3k6l | 2BB | Peptide deformylase | 3.5.1.88 | 0.506 | |
| 1g27 | BB1 | Peptide deformylase | 3.5.1.88 | 0.505 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.504 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.501 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.494 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 3e3u | NVC | Peptide deformylase | 3.5.1.88 | 0.491 | |
| 1lry | BB2 | Peptide deformylase | / | 0.490 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.490 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.488 | |
| 3m6r | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.487 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.484 | |
| 2z1m | NDP | GDP-mannose 4,6-dehydratase | / | 0.483 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.482 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.482 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.481 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.479 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.479 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.477 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.477 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.476 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.476 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.475 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.474 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.474 | |
| 4wxl | BB2 | Peptide deformylase | / | 0.474 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.473 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 4bis | 8HQ | Lysine-specific demethylase 4A | 1.14.11 | 0.473 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.472 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.471 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.471 | |
| 5hsa | FAS | Alcohol oxidase 1 | 1.1.3.13 | 0.471 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.470 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.470 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.470 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.469 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.469 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.469 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.468 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.467 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.467 | |
| 3cgc | COA | Coenzyme A disulfide reductase | / | 0.467 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.467 | |
| 4jic | FMN | GTN Reductase | / | 0.467 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.467 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 3ieu | GDP | GTPase Era | / | 0.466 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.466 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.465 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.464 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.463 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.463 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.463 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 4hxy | NDP | Plm1 | / | 0.463 | |
| 5djt | FMN | NPH1-2 | / | 0.463 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.462 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.462 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.462 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 2a1y | 5GP | GMP reductase | / | 0.461 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.461 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.461 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.461 | |
| 1tsx | UMP | Thymidylate synthase | / | 0.460 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.460 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.460 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.459 | |
| 1kbj | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.459 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.459 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.459 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.459 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.459 | |
| 3tlj | SAH | Uncharacterized protein | / | 0.459 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.459 | |
| 4eue | NAI | Trans-2-enoyl-CoA reductase [NADH] | / | 0.459 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.459 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA2 | 3.6.3 | 0.459 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA1 | / | 0.459 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.458 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.458 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.458 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.458 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.458 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.458 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.458 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.457 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.457 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 4eox | 0S5 | Peptide deformylase | / | 0.457 | |
| 4n57 | ADP | APH(2'')-Id | / | 0.457 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.457 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.456 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3giy | FMN | (S)-mandelate dehydrogenase | 1.1.99.31 | 0.456 | |
| 3u9e | COA | Lmo1369 protein | / | 0.456 | |
| 4cje | Q31 | Integrase | / | 0.456 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4mcc | 21X | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.456 | |
| 1aj8 | COA | Citrate synthase | / | 0.455 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.455 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 1qf5 | RPL | Adenylosuccinate synthetase | / | 0.455 | |
| 1u4o | NDD | L-lactate dehydrogenase | 1.1.1.27 | 0.455 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.455 | |
| 2el0 | SAH | Diphthine synthase | / | 0.455 | |
| 2hck | QUE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.455 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.455 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.455 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 3wtk | TH4 | Acetylcholine-binding protein | / | 0.455 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.455 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.455 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.455 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.454 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.454 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1lqy | BB2 | Peptide deformylase 2 | 3.5.1.88 | 0.454 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2fto | TMP | Thymidylate synthase | / | 0.454 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.454 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 4oh4 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.454 | |
| 1bwk | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.453 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.453 | |
| 1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.453 | |
| 1phh | FAD | p-hydroxybenzoate hydroxylase | / | 0.453 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.453 | |
| 2ie0 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.453 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.453 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.453 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.453 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.452 | |
| 2ag1 | TPP | Benzaldehyde lyase | / | 0.452 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 4afh | L0B | Achbp | / | 0.452 | |
| 4d9e | LCS | D-cysteine desulfhydrase | / | 0.452 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.452 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.451 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.451 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.451 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 2jfz | 003 | Glutamate racemase | / | 0.451 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.451 | |
| 2p2m | PRX | Acetyl-coenzyme A synthetase | / | 0.451 | |
| 2pch | SAH | Diphthine synthase | / | 0.451 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.451 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.451 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.451 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.451 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.451 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.451 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.451 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.450 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.450 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.450 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.450 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.450 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.450 | |
| 4cfa | WOP | Integrase | / | 0.450 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.450 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.450 | |
| 4xr9 | NAD | CalS8 | / | 0.450 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1gqt | ACP | Ribokinase | / | 0.449 | |
| 1gv0 | NAD | Malate dehydrogenase | / | 0.449 | |
| 1um0 | FMN | Chorismate synthase | / | 0.449 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.449 | |
| 2fxf | ACO | Diamine acetyltransferase 1 | / | 0.449 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.449 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 2huq | SAH | Diphthine synthase | / | 0.449 | |
| 3bw2 | FMN | Putative 2-nitropropane dioxygenase | / | 0.449 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.449 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.449 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.449 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.449 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4i9n | 1E5 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.449 | |
| 4ijp | 1EH | Serine/threonine-protein kinase PRP4 homolog | 2.7.11.1 | 0.449 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.449 | |
| 1eio | GCH | Gastrotropin | / | 0.448 | |
| 1kbi | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.448 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.448 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.448 | |
| 2ele | SAH | Diphthine synthase | / | 0.448 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.448 | |
| 2q3k | MUW | Gag-Pol polyprotein | / | 0.448 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.448 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.448 | |
| 4opl | FDA | Conserved Archaeal protein | / | 0.448 | |
| 4y38 | 0A9 | Endothiapepsin | 3.4.23.22 | 0.448 | |
| 1cdo | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.447 | |
| 1hku | NAD | C-terminal-binding protein 1 | 1.1.1 | 0.447 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.447 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.447 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.447 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.447 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.447 | |
| 3bj7 | COA | Diamine acetyltransferase 1 | / | 0.447 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.447 | |
| 3ik6 | HCZ | Glutamate receptor 2 | / | 0.447 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.447 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.447 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.447 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.447 | |
| 3zuy | TCH | Transporter | / | 0.447 | |
| 4cj3 | E4F | Integrase | / | 0.447 | |
| 4ejv | LCL | Transcriptional regulator TcaR | / | 0.447 | |
| 4ew3 | DXZ | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.447 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.447 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.447 | |
| 4pzr | COA | Histone acetyltransferase p300 | / | 0.447 | |
| 1l4f | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.446 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.446 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.446 | |
| 3a14 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.446 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.446 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.446 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.446 | |
| 3zsr | O3N | Integrase | / | 0.446 | |
| 4cez | O3N | Integrase | / | 0.446 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.446 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 1l4m | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.445 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.445 | |
| 2ek4 | SAH | Diphthine synthase | / | 0.445 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.445 | |
| 2p20 | PRX | Acetyl-coenzyme A synthetase | / | 0.445 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.445 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.445 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 3h18 | PMS | Esterase/lipase | / | 0.445 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.445 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.445 | |
| 3mje | NDP | AmphB | / | 0.445 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.445 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4a31 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.445 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.445 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4qi7 | FAD | Cellobiose dehydrogenase | / | 0.445 | |
| 1ci0 | FMN | Pyridoxamine 5'-phosphate oxidase | 1.4.3.5 | 0.444 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.444 | |
| 1rm5 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.444 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.444 | |
| 2i51 | FMN | Pyridoxamine 5'-phosphate oxidase-related, FMN-binding | / | 0.444 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.444 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.444 | |
| 4fv3 | EK6 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.444 | |
| 4pd6 | URI | Nucleoside permease | / | 0.444 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.444 | |
| 4xd2 | NAI | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.444 | |
| 4yqf | GDP | Septin-9 | / | 0.444 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.444 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.443 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1n3r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.443 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2vr1 | ATF | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.443 | |
| 3a20 | FMN | FMN-binding protein | / | 0.443 | |
| 3awh | FMN | FMN-binding protein | / | 0.443 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.443 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.443 | |
| 3efl | 706 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.443 | |
| 3lkh | LT6 | Genome polyprotein | 2.7.7.48 | 0.443 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 3pxv | FMN | Nitroreductase | / | 0.443 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4asj | N6A | Glucose-1-phosphate thymidylyltransferase | / | 0.443 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.443 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.443 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.443 | |
| 4opu | FDA | Conserved Archaeal protein | / | 0.443 | |
| 4rnw | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.443 | |
| 5ag5 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 5c46 | GSP | Ras-related protein Rab-11A | / | 0.443 | |
| 6cts | CIC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.443 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.442 | |
| 1dgm | ADN | Adenosine kinase | 2.7.1.20 | 0.442 | |
| 1e80 | 0GQ | Endothiapepsin | 3.4.23.22 | 0.442 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.442 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.442 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.442 | |
| 1qf4 | RPD | Adenylosuccinate synthetase | / | 0.442 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.442 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.442 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.442 | |
| 2vb8 | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.442 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.442 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.442 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.442 | |
| 3h6v | NS6 | Glutamate receptor 2 | / | 0.442 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.442 | |
| 3td7 | FAD | Probable FAD-linked sulfhydryl oxidase R596 | 1.8.3.2 | 0.442 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.442 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.442 | |
| 4tmb | FMN | Old yellow enzyme | / | 0.442 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.441 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.441 | |
| 1rl4 | BRR | Peptide deformylase | / | 0.441 | |
| 1vji | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.441 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.441 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.441 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.441 | |
| 2gd2 | CAA | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.441 | |
| 2hqp | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2hut | SAH | Diphthine synthase | / | 0.441 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.441 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.441 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.441 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 3zv6 | 4HB | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.441 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 4ck2 | NVU | Integrase | / | 0.441 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.441 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.441 | |
| 4oe4 | NAD | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | 1.2.1.88 | 0.441 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.441 | |
| 4ubv | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.441 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.440 | |
| 1l4g | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.440 | |
| 1z0a | GDP | Ras-related protein Rab-2A | / | 0.440 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.440 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.440 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.440 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.440 | |
| 2gtb | AZP | Orf1ab polyprotein | / | 0.440 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.440 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.440 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.440 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.440 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.440 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.440 | |
| 3ljt | LA3 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.440 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.440 | |
| 3oix | FMN | Dihydroorotate dehydrogenase | / | 0.440 | |
| 3sdi | 3SD | Proteasome subunit beta type-5 | 3.4.25.1 | 0.440 | |
| 3sdi | 3SD | Proteasome subunit beta type-6 | 3.4.25.1 | 0.440 | |
| 3sl2 | ATP | Sensor histidine kinase WalK | / | 0.440 | |
| 3vvp | BNU | Uncharacterized protein | / | 0.440 | |
| 4cgj | NZL | Integrase | / | 0.440 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.440 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.440 |