sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3m4h | 388 | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 1.000 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.872 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.849 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.770 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.756 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.711 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.710 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.707 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.703 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.701 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.695 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.692 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.688 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.683 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.678 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.674 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.671 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.671 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.668 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.665 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.643 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.640 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.633 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.626 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.626 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.625 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.617 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.615 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.613 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.611 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.609 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.609 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.608 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.608 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.607 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.604 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.602 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.601 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.601 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.601 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.600 | |
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.598 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.594 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.591 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.588 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.585 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.585 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.570 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.569 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.567 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.563 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.561 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.561 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.558 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.546 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.543 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.534 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.532 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.523 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.516 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.514 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.511 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.507 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.502 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.494 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.490 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.490 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.489 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.488 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.487 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.486 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.486 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.485 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.485 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.482 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.482 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.481 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.477 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.477 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.477 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.476 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.476 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.475 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.474 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.473 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.472 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.470 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.470 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.470 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.470 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.470 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.470 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.468 | |
| 4kmz | FOL | Folate receptor beta | / | 0.468 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.466 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.465 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.464 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.463 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.463 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.462 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.462 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.462 | |
| 4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.462 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 4phl | PIL | Phosphodiesterase | / | 0.461 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.460 | |
| 1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.459 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.459 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.459 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.459 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.459 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.459 | |
| 1s2c | FLF | Aldo-keto reductase family 1 member C3 | / | 0.458 | |
| 3pn1 | IVH | DNA ligase | / | 0.458 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.457 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.456 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4kn2 | LYA | Folate receptor beta | / | 0.456 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.455 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.455 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.455 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.455 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.453 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.453 | |
| 4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1kyy | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.451 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.451 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.451 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.451 | |
| 4kn0 | MTX | Folate receptor beta | / | 0.451 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.451 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.450 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.449 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.449 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 4b52 | RDF | Bacillolysin | / | 0.449 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.449 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.449 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.448 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.448 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.448 | |
| 3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.447 | |
| 1c7o | PPG | Hemolysin | / | 0.446 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1s36 | CEI | Obelin | / | 0.446 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.446 | |
| 2tpl | HPP | Tyrosine phenol-lyase | 4.1.99.2 | 0.446 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.446 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.445 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.445 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.445 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.445 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4glx | 0XS | DNA ligase | 6.5.1.2 | 0.445 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.444 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.444 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.444 | |
| 4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 1jf2 | CZH | Obelin | / | 0.443 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.443 | |
| 4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.443 | |
| 1gm8 | SOX | Penicillin G acylase | 3.5.1.11 | 0.442 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.442 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 3ocw | 3AM | Lipoprotein E | / | 0.442 | |
| 3ugr | IMN | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 4j7g | TRH | PCZA361.3 | / | 0.442 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 1fml | RTL | Retinol dehydratase | / | 0.441 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.441 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 4blc | NDP | Catalase | 1.11.1.6 | 0.441 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.441 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 5kp2 | COA | 3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2 | / | 0.440 |