Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3m42 | HGF | MAP kinase-activated protein kinase 2 | 2.7.11.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3m42 | HGF | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 1.000 | |
| 3kga | LX9 | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.637 | |
| 3r2b | 05B | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.564 | |
| 3she | I85 | MAP kinase-activated protein kinase 3 | 2.7.11.1 | 0.558 | |
| 1aq1 | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.533 | |
| 4bie | IE6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.522 | |
| 2c6t | DT5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.519 | |
| 4fg9 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.515 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.514 | |
| 4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.512 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.509 | |
| 4e4m | 0NH | Tyrosine-protein kinase JAK2 | / | 0.508 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.504 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.503 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.501 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.500 | |
| 2cgv | 3B3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.497 | |
| 4bib | IEO | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.494 | |
| 4ftu | 7HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.492 | |
| 4fv5 | EK9 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.492 | |
| 1nxk | STU | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.490 | |
| 2cgx | 3D3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.490 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.490 | |
| 2x1n | X1N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.488 | |
| 2ym7 | YM7 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.488 | |
| 4hyh | 1AM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.488 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.487 | |
| 3gub | GUB | Death-associated protein kinase 1 | 2.7.11.1 | 0.487 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.486 | |
| 2uzn | C96 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.486 | |
| 4yuq | KS1 | Calmodulin-like domain protein kinase | / | 0.486 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.485 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.485 | |
| 3kc3 | MK2 | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.485 | |
| 4kbk | 1QG | Casein kinase I isoform delta | 2.7.11.1 | 0.485 | |
| 4fti | H7K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.484 | |
| 4qmz | B49 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.484 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.483 | |
| 4fg8 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.483 | |
| 1om1 | IQA | Casein kinase II subunit alpha | 2.7.11.1 | 0.482 | |
| 1zys | 199 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.482 | |
| 2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.482 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.481 | |
| 2uzl | C94 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.481 | |
| 3uli | 1N3 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.481 | |
| 4fsn | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.481 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.481 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.480 | |
| 3rk5 | 07Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.480 | |
| 2iw9 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.479 | |
| 3rk7 | 08Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.479 | |
| 4ft0 | HK9 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.479 | |
| 3lfn | A27 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.478 | |
| 3rmf | 20Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.478 | |
| 3v5l | 0G1 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.478 | |
| 4lop | SB4 | Mitogen-activated protein kinase 14 | / | 0.478 | |
| 4i0s | 1B5 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.477 | |
| 4iwd | 1JC | Hepatocyte growth factor receptor | 2.7.10.1 | 0.477 | |
| 2bhh | RYU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.476 | |
| 2iw8 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.476 | |
| 3hzt | J60 | Calmodulin-like domain protein kinase isoform 3 | / | 0.476 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.476 | |
| 2e9o | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.475 | |
| 2e9v | 85A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.475 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.475 | |
| 4ft5 | H2K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.475 | |
| 4hyi | 1AO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.475 | |
| 4kb8 | 1QN | Casein kinase I isoform delta | 2.7.11.1 | 0.475 | |
| 4yzc | STU | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.475 | |
| 1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.474 | |
| 1nvr | STU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.474 | |
| 2dwb | ANP | Aurora kinase A | 2.7.11.1 | 0.474 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.474 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.473 | |
| 2gdo | 12C | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.473 | |
| 4fsz | HK8 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.473 | |
| 1y91 | CT9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.472 | |
| 2bro | DF2 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.472 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.472 | |
| 4fkv | 61K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.472 | |
| 4l52 | 1UL | Mitogen-activated protein kinase kinase kinase 7 | 2.7.11.25 | 0.472 | |
| 2bkz | SBC | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.471 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.471 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.471 | |
| 3ork | AGS | Serine/threonine protein kinase | / | 0.471 | |
| 1h1r | 6CP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.470 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.470 | |
| 3f69 | XDR | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.470 | |
| 4hnf | 16W | Casein kinase I isoform delta | 2.7.11.1 | 0.470 | |
| 2r0u | M54 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.469 | |
| 2w05 | FRT | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.469 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.469 | |
| 2ym6 | YM6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.469 | |
| 3i4b | Z48 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.469 | |
| 3nlb | 5BE | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.469 | |
| 1oir | HDY | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.468 | |
| 2xnb | Y8L | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.468 | |
| 4h3f | 10O | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 1fvv | 107 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.467 | |
| 3sw7 | 19K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.467 | |
| 4gh2 | HK0 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.467 | |
| 2w0j | ZAT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.466 | |
| 2ym4 | 4YM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.466 | |
| 3t8o | ATP | Rhodopsin kinase | / | 0.466 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.466 | |
| 4ftk | H9K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 4hgt | 15G | Casein kinase I isoform delta | 2.7.11.1 | 0.466 | |
| 1g5s | I17 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.465 | |
| 1xjd | STU | Protein kinase C theta type | 2.7.11.13 | 0.465 | |
| 3cbl | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.465 | |
| 3wi6 | YRZ | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.465 | |
| 1gih | 1PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.464 | |
| 1unl | RRC | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.464 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.464 | |
| 2xbj | XBJ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.464 | |
| 3a60 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.464 | |
| 3be9 | P04 | Casein kinase II subunit alpha | 2.7.11.1 | 0.464 | |
| 3lfq | A28 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.464 | |
| 4ek8 | 16K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.464 | |
| 4qmp | DKI | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.464 | |
| 2wmu | ZYU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.463 | |
| 3nyn | SGV | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.463 | |
| 1oi9 | N20 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.462 | |
| 2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 2brg | DFY | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.462 | |
| 2r3i | SCF | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.462 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.462 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.462 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 4acg | 6LQ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.462 | |
| 4loq | SB4 | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 1vik | BAY | Gag-Pol polyprotein | / | 0.461 | |
| 2p3b | 3TL | V-1 PROTEASE protein | / | 0.461 | |
| 2p3b | 3TL | V-1 protease | / | 0.461 | |
| 2wih | P48 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 3c50 | ADP | Rhodopsin kinase | / | 0.461 | |
| 3uyt | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.461 | |
| 4feq | 0T8 | Tyrosine-protein kinase receptor TYRO3 | 2.7.10.1 | 0.461 | |
| 5drd | ATP | Aurora kinase A | 2.7.11.1 | 0.461 | |
| 2vto | LZ8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.460 | |
| 2wmq | ZYQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.460 | |
| 2xm9 | LWH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.460 | |
| 3gu7 | ADP | Death-associated protein kinase 1 | 2.7.11.1 | 0.460 | |
| 3hrc | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.460 | |
| 3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.460 | |
| 4ftc | H6K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.460 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.460 | |
| 3jxw | LXG | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.459 | |
| 3rni | 21Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 1h1s | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 1q8y | ADP | Serine/threonine-protein kinase SKY1 | 2.7.11.1 | 0.458 | |
| 2fxd | DR7 | Pol polyprotein | / | 0.458 | |
| 2hxq | 373 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 4bdc | ODH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.458 | |
| 4fsu | HK5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 4ftm | 1HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 1oiy | N41 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 1phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.457 | |
| 2pvn | P63 | Casein kinase II subunit alpha | 2.7.11.1 | 0.457 | |
| 2uze | C95 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 2yex | YEX | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 3sdk | P3N | Proteasome subunit beta type-5 | 3.4.25.1 | 0.457 | |
| 3sdk | P3N | Proteasome subunit beta type-6 | 3.4.25.1 | 0.457 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 4ach | KDI | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.457 | |
| 4acm | 7YG | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 4fr4 | STU | Serine/threonine-protein kinase 32A | 2.7.11.1 | 0.457 | |
| 5cno | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.457 | |
| 1e9h | INR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 1zlt | HYM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 2brh | DFW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.456 | |
| 4acc | 7YG | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.456 | |
| 4dn5 | AGS | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.456 | |
| 4fv6 | E57 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.456 | |
| 5dr6 | SKE | Aurora kinase A | 2.7.11.1 | 0.456 | |
| 1dm2 | HMD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 2b52 | D42 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 2euf | LQQ | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.455 | |
| 2iw6 | QQ2 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 2rio | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.455 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 2xmy | CDK | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.455 | |
| 3cyw | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 3qu0 | X40 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 3sqq | 99Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 3uzp | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.455 | |
| 3zc6 | VFC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.455 | |
| 1m2r | MNY | Casein kinase II subunit alpha | 2.7.11.1 | 0.454 | |
| 1p4f | DRG | Death-associated protein kinase 1 | 2.7.11.1 | 0.454 | |
| 1pxl | CK4 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 1pxm | CK5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.454 | |
| 2x8e | X8E | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 3ral | 04Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3s1h | 56Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3zm4 | 22T | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.454 | |
| 4erw | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 4hgl | 0YO | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.454 | |
| 4k1b | 1OC | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.454 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.453 | |
| 1ny3 | ADP | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.453 | |
| 1ogu | ST8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 2fum | MIX | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.453 | |
| 3lin | E13 | Protease | / | 0.453 | |
| 3slz | 3TL | Putative gag-pro-pol polyprotein | / | 0.453 | |
| 4btj | ADP | Tau-tubulin kinase 1 | 2.7.11.1 | 0.453 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.453 | |
| 1bw9 | NAD | Phenylalanine dehydrogenase | / | 0.452 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 2c5n | CK8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.452 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.452 | |
| 3qzg | X67 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 4dgm | AGI | Casein kinase II subunit alpha | 2.7.11.1 | 0.452 | |
| 4fg7 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.452 | |
| 4ft9 | H4K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 4jqe | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.452 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.451 | |
| 1gqt | ACP | Ribokinase | / | 0.451 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.451 | |
| 1vjy | 460 | TGF-beta receptor type-1 | 2.7.11.30 | 0.451 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 2f3k | RO1 | Protease | / | 0.451 | |
| 2ym5 | YM5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 3dog | NNN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.451 | |
| 3so9 | 017 | Pol protein | / | 0.451 | |
| 3zpt | M8Y | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 4eon | 1RO | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 4gih | 0X5 | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.451 | |
| 4qi4 | FAD | Cellobiose dehydrogenase | / | 0.451 | |
| 4qmt | H1N | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.451 | |
| 5dt3 | ATP | Aurora kinase A | 2.7.11.1 | 0.451 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.450 | |
| 1stc | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.450 | |
| 2wmt | ZYT | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 2wti | WTI | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.450 | |
| 3a62 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.450 | |
| 3cyx | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 3kfs | 3TL | Gag-Pol polyprotein | / | 0.450 | |
| 3pj8 | 404 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4fks | 46K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.450 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 1pxp | CK8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 4o0w | ADN | Aurora kinase A | 2.7.11.1 | 0.449 | |
| 4ux9 | ANP | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.449 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 2bpw | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 2h96 | 893 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.448 | |
| 2xch | CKG | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 3t3c | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 4bdh | WVI | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.448 | |
| 4qi7 | FAD | Cellobiose dehydrogenase | / | 0.448 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 2b8l | 5HA | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.447 | |
| 2r5q | 1UN | Gag-Pol polyprotein | / | 0.447 | |
| 2wmw | ZYW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 3gga | GGW | Gag-Pol polyprotein | / | 0.447 | |
| 3lct | ADP | ALK tyrosine kinase receptor | 2.7.10.1 | 0.447 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.447 | |
| 3tuc | FPW | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.447 | |
| 4agu | D15 | Cyclin-dependent kinase-like 1 | / | 0.447 | |
| 4bcm | T7Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 4fko | 20K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 5aac | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.447 | |
| 1q41 | IXM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.446 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.446 | |
| 2vag | V25 | Dual specificity protein kinase CLK1 | 2.7.12.1 | 0.446 | |
| 2vtj | LZ4 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3lzs | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.446 | |
| 4idt | T28 | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.446 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.446 | |
| 1ke6 | LS2 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.445 | |
| 2vu3 | LZE | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3el9 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3ggf | GVD | Serine/threonine-protein kinase 26 | / | 0.445 | |
| 4a06 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.445 | |
| 4dgn | LU2 | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 4eok | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 4fod | 0UV | ALK tyrosine kinase receptor | 2.7.10.1 | 0.445 | |
| 4fsm | HK1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 4ft3 | H1K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.445 | |
| 1pmn | 984 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.444 | |
| 1uv5 | BRW | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.444 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.444 | |
| 2am2 | 2LG | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.444 | |
| 2c47 | 5ID | Casein kinase I isoform gamma-2 | / | 0.444 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.444 | |
| 2cgu | 3A3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2p3c | 3TL | Protease | / | 0.444 | |
| 3bqr | 4RB | Death-associated protein kinase 3 | / | 0.444 | |
| 3ndx | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3sdi | 3SD | Proteasome subunit beta type-5 | 3.4.25.1 | 0.444 | |
| 3sdi | 3SD | Proteasome subunit beta type-6 | 3.4.25.1 | 0.444 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.444 | |
| 4bgh | 3I6 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 4j5j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.444 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 1gii | 1PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 1ml3 | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.443 | |
| 1oit | HDT | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.443 | |
| 1yt9 | OIS | Gag-Pol polyprotein | / | 0.443 | |
| 2e9p | 77A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2fdd | 385 | Pol protein | / | 0.443 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 2hm1 | LIQ | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2nnp | ROC | Protease | / | 0.443 | |
| 2w7x | D1A | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.443 | |
| 2wtd | ZZK | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.443 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.443 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3pwr | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3qd3 | 3Q5 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 3ufn | ROC | Gag-Pol polyprotein | / | 0.443 | |
| 3zlx | 5EZ | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.443 | |
| 4dqb | 017 | Gag-Pol polyprotein | / | 0.443 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.443 | |
| 4mq2 | 2C4 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.443 | |
| 4qgi | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.443 | |
| 5dnr | ATP | Aurora kinase A | 2.7.11.1 | 0.443 | |
| 1gij | 2PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1r78 | FMD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 1sgu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2ayp | 43A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.442 | |
| 3qtx | X43 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 4bcp | T3C | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 4ijp | 1EH | Serine/threonine-protein kinase PRP4 homolog | 2.7.11.1 | 0.442 | |
| 4jik | 1KO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1fvt | 106 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 1k2c | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1p2a | 5BN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.441 | |
| 2gcd | STU | Serine/threonine-protein kinase TAO2 | 2.7.11.1 | 0.441 | |
| 2q63 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2vuw | 5ID | Serine/threonine-protein kinase haspin | 2.7.11.1 | 0.441 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3elj | GS7 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.441 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.441 | |
| 3nun | JMZ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 4fkr | 45K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4j55 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1m0b | 0ZQ | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2cn8 | DBQ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.440 | |
| 2f81 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.440 | |
| 2y9q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.440 | |
| 3a3g | DLZ | Lumazine protein | / | 0.440 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.440 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 3ddp | RC8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3iok | 1P6 | Tyrosine-protein kinase JAK2 | / | 0.440 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.440 | |
| 3orm | AGS | Serine/threonine protein kinase | / | 0.440 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.440 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.440 | |
| 3ucb | 017 | Gag-Pol polyprotein | / | 0.440 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 4im2 | BX7 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.440 | |
| 4k33 | ACP | Fibroblast growth factor receptor 3 | 2.7.10.1 | 0.440 | |
| 4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.440 | |
| 4n9i | PCG | Catabolite expression activator | / | 0.440 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.440 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.440 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 5dt4 | ATP | Aurora kinase A | 2.7.11.1 | 0.440 |