sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3m0i | ZST | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 1.000 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.693 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.690 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.658 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.648 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.645 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.644 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.637 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.631 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.630 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.627 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.626 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.626 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.625 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.622 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.619 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.618 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.617 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.616 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.615 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.614 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.611 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.610 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.610 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.606 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.605 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.602 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.602 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.598 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.598 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.594 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.592 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.591 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.591 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.591 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.590 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.588 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.587 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.587 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.586 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.585 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.584 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.583 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.582 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.581 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.580 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.570 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.570 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.566 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.563 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.557 | |
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.550 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.549 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.542 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.540 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.538 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.532 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.522 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.513 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.506 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.493 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.490 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.487 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.485 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.485 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.483 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.481 | |
| 4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.481 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 2v0m | KLN | Cytochrome P450 3A4 | / | 0.479 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.478 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.478 | |
| 4uy6 | SAH | Histidine N-alpha-methyltransferase | / | 0.477 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.474 | |
| 4xwt | U5P | Ribonuclease J | / | 0.474 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.473 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.472 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.470 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.470 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.470 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.470 | |
| 1pj7 | FFO | Dimethylglycine oxidase | 1.5.3.10 | 0.469 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.469 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.469 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.468 | |
| 4kmz | FOL | Folate receptor beta | / | 0.468 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.466 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.466 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.466 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.465 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.465 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 2y1w | 849 | Histone-arginine methyltransferase CARM1 | / | 0.464 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.464 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.464 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.463 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.462 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3hii | PNT | Amiloride-sensitive amine oxidase [copper-containing] | / | 0.462 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 4nwi | CTN | 7-methylguanosine phosphate-specific 5'-nucleotidase | / | 0.462 | |
| 1ddt | APU | Diphtheria toxin | / | 0.461 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.461 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.461 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.461 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.460 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.460 | |
| 4e2y | JHZ | Methyltransferase | / | 0.460 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.460 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.460 | |
| 1jf0 | CZH | Obelin | / | 0.459 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.459 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.459 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.458 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.458 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.458 | |
| 2hzq | STR | Apolipoprotein D | / | 0.458 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.458 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.458 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.457 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.457 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.457 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.457 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 4k88 | HFG | Bifunctional glutamate/proline--tRNA ligase | 6.1.1.15 | 0.457 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.456 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.456 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.456 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.455 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.455 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.455 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.455 | |
| 3x04 | GNP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.455 | |
| 3ny8 | JRZ | Beta-2 adrenergic receptor | / | 0.455 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.454 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.454 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
| 2oym | MNI | Endoglycoceramidase II | / | 0.453 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.453 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 4hyf | 1AK | Tankyrase-2 | 2.4.2.30 | 0.453 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.453 | |
| 4zm6 | ACO | N-acetyl-beta-D glucosaminidase | / | 0.453 | |
| 1dtp | APU | Diphtheria toxin | / | 0.452 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.452 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.452 | |
| 2aot | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.452 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 3x02 | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.452 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.452 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.452 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.451 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.451 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 3hgg | CHD | CmeR | / | 0.451 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.451 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.451 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.451 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.451 | |
| 1qv0 | CZH | Obelin | / | 0.450 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.450 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.450 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.450 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.450 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.450 | |
| 3w0u | HPW | Lactoylglutathione lyase | 4.4.1.5 | 0.450 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.449 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.449 | |
| 2jf6 | S55 | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.449 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.449 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.449 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.449 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.448 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.448 | |
| 2vdy | HCY | Corticosteroid-binding globulin | / | 0.448 | |
| 2y1x | 845 | Histone-arginine methyltransferase CARM1 | / | 0.448 | |
| 3t31 | DCQ | Sulfide-quinone reductase | / | 0.448 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.448 | |
| 5jqh | CAU | Beta-2 adrenergic receptor | / | 0.448 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 1tfz | 869 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.447 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 3frk | TQP | QdtB | / | 0.447 | |
| 3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.447 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.447 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.447 | |
| 1ej3 | CZH | Aequorin-2 | / | 0.446 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1yry | MSG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 3abx | RCB | Glucanase | / | 0.446 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.446 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4mzu | TYD | WxcM-like protein | / | 0.446 | |
| 4nbi | D3Y | D-tyrosyl-tRNA(Tyr) deacylase | / | 0.446 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.445 | |
| 1rpw | DID | HTH-type transcriptional regulator QacR | / | 0.445 | |
| 1sg0 | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.445 | |
| 1ye4 | NAD | NAD(P)H-dependent D-xylose reductase | 1.1.1.307 | 0.445 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.445 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.445 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.445 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 4bvh | OCZ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.445 | |
| 4bvn | P32 | Beta-1 adrenergic receptor | / | 0.445 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.445 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.445 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 5ds3 | 09L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.445 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.445 | |
| 3ny9 | JSZ | Beta-2 adrenergic receptor | / | 0.445 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.444 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 3gsi | THG | Dimethylglycine oxidase | 1.5.3.10 | 0.444 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.444 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.444 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4tm3 | FAD | KtzI | / | 0.444 | |
| 1al7 | HST | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.443 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.443 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 1v7a | FRC | Adenosine deaminase | 3.5.4.4 | 0.443 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.443 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.443 | |
| 4kn0 | MTX | Folate receptor beta | / | 0.443 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 4li8 | 1XQ | Tankyrase-1 | 2.4.2.30 | 0.443 | |
| 4msk | 2C8 | Tankyrase-1 | 2.4.2.30 | 0.443 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.443 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.443 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 1qv1 | CZH | Obelin | / | 0.442 | |
| 1vp5 | NAP | Oxidoreductase, aldo/keto reductase family | / | 0.442 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.442 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.442 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 4jt9 | 1NS | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.442 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1m9m | 6NI | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.441 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1s2c | FLF | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.441 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.441 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 3d2d | REN | Reticuline oxidase | 1.21.3.3 | 0.441 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 3zho | FMN | NAD(P)H dehydrogenase (quinone) | / | 0.441 | |
| 4e2z | JHZ | Methyltransferase | / | 0.441 | |
| 4nv7 | COA | Arylamine N-acetyltransferase | / | 0.441 | |
| 4to1 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.441 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.441 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.440 | |
| 1fml | RTL | Retinol dehydratase | / | 0.440 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.440 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.440 | |
| 1vrq | FON | Subunit alpha of sarocosine oxidase | / | 0.440 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.440 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.440 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4bb2 | STR | Corticosteroid-binding globulin | / | 0.440 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.440 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.440 | |
| 4ami | G90 | Beta-1 adrenergic receptor | / | 0.440 |