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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3lt1FT2Enoyl-ACP reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3lt1FT2Enoyl-ACP reductase/1.000
3lt0FT1Enoyl-ACP reductase/0.721
3lt2FT3Enoyl-ACP reductase/0.674
3am3TCLEnoyl-ACP reductase/0.668
2ol4JPNEnoyl-ACP reductase/0.641
4igeCHJEnoyl-acyl carrier reductase/0.632
1nnuTCTEnoyl-ACP reductase/0.588
1uh5TCLEnoyl-ACP reductase/0.562
3f4bTCLEnoyl-acyl carrier protein reductase/0.561
1nhgTCLEnoyl-ACP reductase/0.553
1nhwTCCEnoyl-ACP reductase/0.552
1zw1TN5Enoyl-ACP reductase/0.550
3am4FT1Enoyl-ACP reductase/0.550
3nj8NJ8Enoyl-acyl carrier reductase/0.543
3lsyFT0Enoyl-ACP reductase/0.542
2o2yTCLEnoyl-ACP reductase/0.540
2foiJPAEnoyl-acyl carrier reductase/0.539
3am5TCLEnoyl-ACP reductase/0.531
1zxlJP1Enoyl-ACP reductase/0.530
2op07PCEnoyl-ACP reductase/0.530
1zsnTN2Enoyl-ACP reductase/0.528
2o2sTCLEnoyl-acyl carrier reductase/0.524
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.497
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.496
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.493
2q9fC3SCholesterol 24-hydroxylase/0.483
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.480
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.477
5coqTCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.473
3nrcTCLEnoyl-[acyl-carrier-protein] reductase [NADH]/0.469
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.468
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.467
4n3r2GUTankyrase-12.4.2.300.467
3q0uLL3HTH-type transcriptional regulator EthR/0.465
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.462
5f8eSAHPossible transcriptional regulatory protein/0.462
1rf9DBRCamphor 5-monooxygenase1.14.15.10.461
3p6nDSOCamphor 5-monooxygenase1.14.15.10.461
3o8gO8GHTH-type transcriptional regulator EthR/0.460
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.458
3k4nFADPyranose 2-oxidase/0.458
3fne8PCEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.455
5jscFADPutative acyl-CoA dehydrogenase/0.455
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.453
3p6mDSOCamphor 5-monooxygenase1.14.15.10.453
1re9DSOCamphor 5-monooxygenase1.14.15.10.452
3gkiCLRNiemann-Pick C1 protein/0.452
3g1mRF3HTH-type transcriptional regulator EthR/0.451
3p6pA6BCamphor 5-monooxygenase1.14.15.10.451
4j6bPLOCytochrome P450 monooxygenase/0.451
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.449
5c3jFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.449
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.448
4dc0NDPPutative ketoacyl reductase1.3.10.448
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
2iqgF2IBeta-secretase 13.4.23.460.447
2vqoTFGHistone deacetylase 43.5.1.980.447
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.447
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.447
3sufSUEPolyprotein/0.446
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.446
4c2yMYAGlycylpeptide N-tetradecanoyltransferase 1/0.446
4j6dTESCytochrome P450 monooxygenase/0.446
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.446
2gesCOKPantothenate kinase2.7.1.330.445
3gkjHC3Niemann-Pick C1 protein/0.445
3gw9VNILanosterol 14-alpha-demethylase/0.445
3ol5SAWCamphor 5-monooxygenase1.14.15.10.445
4q71FADBifunctional protein PutA/0.445
1ye4NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.444
3k4cFADPyranose 2-oxidase/0.444
3up0D7SaceDAF-12/0.444
4gyy12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.444
4yntFDAGlucose oxidase, putative/0.444
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1mxtFAECholesterol oxidase1.1.3.60.443
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.443
2q4wFADCytokinin dehydrogenase 71.5.99.120.443
1mbzIOTCarboxyethyl-arginine beta-lactam-synthase6.3.3.40.442
2ykbYKBHeat shock protein HSP 90-alpha/0.442
4j6cSTRCytochrome P450 monooxygenase/0.442
3p6oETGCamphor 5-monooxygenase1.14.15.10.441
4at0FADPossible succinate dehydrogenase/0.441
4q72FADBifunctional protein PutA/0.441
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4ez8DHFThymidylate synthase2.1.1.450.440
4jbtASDCytochrome P450 monooxygenase/0.440