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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3lq4TDPPyruvate dehydrogenase E1 component1.2.4.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3lq4TDPPyruvate dehydrogenase E1 component1.2.4.11.000
2qtaTDPPyruvate dehydrogenase E1 component1.2.4.10.577
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.574
1rp7TZDPyruvate dehydrogenase E1 component1.2.4.10.560
1l8aTDPPyruvate dehydrogenase E1 component1.2.4.10.537
2ieaTDPPyruvate dehydrogenase E1 component1.2.4.10.519
2qtcTDKPyruvate dehydrogenase E1 component1.2.4.10.497
1ay0TPPTransketolase 12.2.1.10.478
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.10.461
2r5nTPPTransketolase 1/0.445